Editor-in-Chief Emeritus Pick of Papers
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For each issue of Radiotherapy and Oncology, the Editor-in-Chief Emeritus Jens Overgaard, picks his favourite papers.
- Investigators have recently reported significant negative associations between heart irradiation and overall survival (OS) following radical radiotherapy (RT) for non-small cell lung cancer (NSCLC) [1–8]. We analysed OS in a cohort of patients, ‘IDEAL-6′, treated in the IDEAL-CRT phase 1/2 trial of isotoxically dose-escalated RT for locally-advanced NSCLC given in 30 fractions over 6 weeks concurrent with chemotherapy [8,9]. OS was significantly associated with one principal component (PC) of patients’ heart dose-distributions, which described fractional heart volumes receiving equivalent doses in 2 Gy fractions (EQD2) of 64–73 Gy (α/β = 3 Gy ), delivered largely to the left atrial (LA) wall.
- Staging at the time of diagnosis is a crucial step in cancer management. It facilitates research activities, guides future treatment protocol development, and enhances cancer control activities . The 8th edition TNM classification (TNM-8) unified nasopharyngeal cancer (NPC) staging systems among endemic and non-endemic jurisdictions and is used worldwide. Modification of T-classification criteria in TNM-8 reflected improved outcomes with contemporary NPC management based on datasets in NPC endemic regions .
- Metastatic extradural spinal cord compression (MESCC) is a devastating complication of advanced malignancy. It may cause a significant deterioration in overall physical function and quality of life (QOL). Published guidelines define MESCC as “compression of the dural sac and its contents (spinal cord and/or cauda equina) by an extradural tumour mass”, with at least “indentation of the theca at the level of clinical features” required for diagnosis [1,2]. MESCC may therefore, be subclinical, or be accompanied by neurologic symptoms including pain, numbness, weakness, and loss of bowel and bladder sphincter control.
- Hepatocellular carcinoma (HCC) is a raising condition both world-wide and in Europe, already being one of the leading causes of cancer-specific deaths. Particular characteristics of the disease associated with its location in the liver and mixed etiology remain a challenge. Surgery, both liver resection and liver transplant, is the recommended curative treatment for the eligible patients. However, presence of cirrhosis, localization and extent of the tumor, performance status and comorbidities limit the number of qualifying patients.
- To describe long-term failure pattern after early-stage breast cancer in relation to local treatment (breast-conserving therapy (BCT) or mastectomy) and age.