Editor-in-Chief Emeritus Pick of Papers
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For each issue of Radiotherapy and Oncology, the Editor-in-Chief Emeritus Jens Overgaard, picks his favourite papers.
- Anal cancer (AC) is an uncommon disease, yet over the past decade the incidence of anal cancer has increased by 2.2% each year . Development of anal cancer is strongly associated with the presence of human papilloma virus (HPV) infection, with >90% of anal cancers directly attributed to HPV .
- Second primary cancers (SPCs) occur in 3–40% of cancer survivors within 10 to more than 40 years after diagnosis of the first cancer [1–7], in part as late effects of treatments. Cancer survivors initially treated with radiotherapy (RT) at age ≥18 years have long-term risks of SPC incidence (all sites combined) 1.1–3 times higher than the general population , and the estimated risks relative to the general population are 5–10 after childhood cancers [8,9].
- While surgery is the preferred option for isolated, operable liver metastases from colorectal cancer (CRC), ablative techniques are endorsed for medically or technically inoperable lesions. Stereotactic body radiotherapy (SBRT) is an alternative ablative local therapy that delivers high RT doses in a few fractions to the cancer, sparing surrounding critical tissue. We have performed a systematic review of published trials to evaluate the efficacy of SBRT as a primary modality therapy for CRC liver oligometastases.
- Background and purpose: Oesophageal cancer is the sixth leading cause of cancer death worldwide and radiotherapy plays a prominent role in its treatment. The presence of lymph node (LN) metastasis has been demonstrated to be one of the most significant prognostic factors related to oesophageal cancer. The use of elective lymph node irradiation (ENI) is still a topic of persistent controversy. The conservative school is to irradiate positive lymph nodes only; the other school is to prophylactically irradiate the regional lymph node area according to different tumour sites.