Editor-in-Chief Emeritus Pick of Papers
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For each issue of Radiotherapy and Oncology, the Editor-in-Chief Emeritus Jens Overgaard, picks his favourite papers.
- Worldwide, approximately 710,000 patients are diagnosed annually with head and neck cancer (HNC) [1,2].
- Up to the late nineties, most departments used Cobalt-60 (Co-60) Units for radiation therapy (RT) for superficially located indications, including postmastectomy RT (PMRT) for early breast cancer. With the transition to linear accelerator photon-based RT, bolus material was often added to allow for a similar surface dose distribution as received with the Co-60 machines due to the skin sparing effect of photons . Bolus serves as a tissue equivalent material that shifts the 95–100% isodose towards the skin and subcutaneous tissue (depending on the thickness of bolus and subcutaneous tissue) .
- Delineation of target and ‘organ at risk’ volumes is a critical part of modern radiation therapy planning, the next essential step after deciding the indication, patient discussion and image acquisition. Adoption of volume-based treatment planning for non-metastatic breast cancer has increased greatly along with the use of improved planning techniques, essential for modern therapy. However, identifying the volumes on a planning CT is no easy task. The current paper is written by ESTRO’s breast course faculty, providing tricks and tips for target volume definition and delineation for optimal postoperative breast cancer irradiation.
- Grade II gliomas (LGG) are primary slow growing brain tumors deriving from glial cells and comprising approximately 15% of all primary brain tumors. They tend to affect younger people, usually before the age of 50 and allow an estimated average survival of 8–15 years [1,2]. Grade I gliomas affect mainly children and are frequently curable, in case a complete excision has been achieved. Unfortunately, grade II gliomas are known to transform to higher grade tumors [3,4]. To date, there is still considerable debate regarding the optimal treatment modality strategy.
- Hepatocellular carcinoma (HCC) is the fifth most common solid tumor and the third most common cause of cancer-related death worldwide, accounting for 600,000 deaths per year . The preferred curative modality is surgical resection; however, only 30% of patients with HCC are suitable candidates for surgery because of inadequate liver function, poor performance status, or locally advanced tumors [2,3]. Radiofrequency ablation (RFA) is another curative option, which might yield long-term tumor control and exhibit comparable results to primary resection for small HCCs [4,5].
- Safety profile of the interaction between anticancer drugs and radiation is a recurrent question. However, there are little data regarding the non-anticancer treatment (NACT)/radiation combinations. The aim of the present study was to investigate concomitant NACTs in patients undergoing radiotherapy in a French comprehensive cancer center.
- Filling the gap in cancer care in underserved regions worldwide requires global collaboration and concerted effort to share creative ideas, pool talents and develop sustainable support from governments, industry, academia and non-governmental organizations. Comprehensive cancer care, which fits within and strengthens the broader healthcare system, ranges from prevention to screening, to curative treatment, to palliative care and to long-term follow-up. Radiation therapy is an essential component for curative and palliative cancer care and can serve as a stable focal point physically and for personnel around which regional cancer and health care programs can be established.
- To characterize the cosmetic outcomes and local recurrence (LR) rates of various hypofractionated radiation therapy (RT) regimens for skin basal and squamous cell cancers (BCCs/SCCs).
- This study aimed to assess the incidence and risk of hypothyroidism among patients with nasopharyngeal carcinoma (NPC) after radiation therapy (RT).
- Recent advances in pediatric cancer treatment have improved disease control and survival outcomes for childhood cancers survivors, including those treated for primary central nervous system and skull base malignancies. Future research in this population will focus on identifying risk factors for infertility, novel screening techniques and recommendations, and quality-of-life outcomes improvement. The purpose of this review is to define the infertility complications observed in pediatric cancer survivors who receive cranial irradiation for central nervous system and skull base malignancies.