Editor-in-Chief Emeritus Pick of Papers
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For each issue of Radiotherapy and Oncology, the Editor-in-Chief Emeritus Jens Overgaard, picks his favourite papers.
- Lung cancer is the leading cause of cancer mortality, representing 13% of new cancer diagnoses in men and women, and accounting for 25% of cancer-related mortality . The 5-year overall survival (OS) in patients with lung cancer is poor (19%) . Radiotherapy forms a critical aspect of the curative treatment of non-small cell lung cancer, particularly in Stage III disease, and medically inoperable patients with Stage I/II disease. Although a number of clinical factors that predict outcome for patients with lung cancer have been reported, including stage, age, smoking status, and mutation status [2,3], lung cancer prognostication is challenging, with no universal model providing significant prediction gains beyond stratification by stage alone .
- Prognostic models are powerful tools for treatment personalisation. However, not all proposed models work well when validated using new data, despite impressive results being reported initially. Here, we will use a hands-on approach to highlight important aspects of prognostic modelling, as well as to demonstrate methods to generate generalisable models.
- Commonly used clinical models for survival prediction after stereotactic radiosurgery (SRS) for brain metastases (BMs) are limited by the lack of individual risk scores and disproportionate prognostic groups. In this study, two nomograms were developed to overcome these limitations.