Editor-in-Chief Emeritus Pick of Papers
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For each issue of Radiotherapy and Oncology, the Editor-in-Chief Emeritus Jens Overgaard, picks his favourite papers.
- Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignancy with a high propensity for local recurrence and regional and distant metastases. Primarily affecting the elderly (average age of presentation is 69 years), the incidence of MCC is slightly higher in men and occurs most commonly in sun-exposed areas of the body (50% head and neck, 40% extremities) . MCCs are considered rare tumours that have almost tripled in incidence over the last 25 years; from a rate of 0.15 cases per 100,000 in 1986 to 0.44 cases per 100,000 in 2001.
- Nasopharyngeal carcinoma (NPC) is among the most common head and neck cancers in southern China, affecting 15–50 per 100,000 people [1,2]. Because NPC is highly radiosensitive, radiotherapy (RT) is an effective treatment . However, with the 5-year survival rate now above 50%, late complications such as those reported in our previous work (optic neuropathy, brachial plexus injury and brain necrosis) [4–6] are an increasing problem.
- Hepatocellular carcinoma (HCC) is the fifth most common solid tumor and the third most common cause of cancer-related death worldwide, accounting for 600,000 deaths per year . The preferred curative modality is surgical resection; however, only 30% of patients with HCC are suitable candidates for surgery because of inadequate liver function, poor performance status, or locally advanced tumors [2,3]. Radiofrequency ablation (RFA) is another curative option, which might yield long-term tumor control and exhibit comparable results to primary resection for small HCCs [4,5].
- To characterize the cosmetic outcomes and local recurrence (LR) rates of various hypofractionated radiation therapy (RT) regimens for skin basal and squamous cell cancers (BCCs/SCCs).
- PET/CT is a proposed management to improve the accuracy of high dose radiochemotherapy in lung cancer patients. This systematic review was performed to investigate the possible impact on clinical outcome and to quantify the effect on patient selection and target definition.
- Induction chemotherapy with docetaxel, cisplatin and 5 FU (TPF) before radiotherapy (RT) or radio-chemotherapy (RT-CHX) has been shown to improve overall survival (OS) compared to induction chemotherapy with cisplatin and 5 FU in locally advanced squamous cell carcinoma of the head and neck (HNSCC). Whether TPF induction before RT-CHX improves clinical outcome in comparison with RT-CHX alone is still a matter of debate. Recently, the results of 5 randomized trials addressing this question have become available.
- Heterotopic ossification (HO) involves the formation of lamellar bone in nonosseous tissue. For HO, radiotherapy has been shown to be an effective prophylactic modality.
- To perform a systematic review and meta-analysis to compare the clinical outcomes and toxicity of hepatocellular carcinoma (HCC) patients treated with charged particle therapy (CPT) with those of individuals receiving photon therapy.
- We conducted a systematic review and meta-analysis to quantify the pathological complete response (pCR) rate after preoperative (chemo)radiation with doses of ⩾60 Gy in patients with locally advanced rectal cancer. Complete response is relevant since this could select a proportion of patients for which organ-preserving strategies might be possible. Furthermore, we investigated correlations between EQD2 dose and pCR-rate, toxicity or resectability, and additionally between pCR-rate and chemotherapy, boost-approach or surgical-interval.