Editor-in-Chief Emeritus Pick of Papers
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For each issue of Radiotherapy and Oncology, the Editor-in-Chief Emeritus Jens Overgaard, picks his favourite papers.
- Anal cancer (AC) is an uncommon disease, yet over the past decade the incidence of anal cancer has increased by 2.2% each year . Development of anal cancer is strongly associated with the presence of human papilloma virus (HPV) infection, with >90% of anal cancers directly attributed to HPV .
- With annual incidence of 0.5 per 100,000, anal cancer accounts for <3% of lower gastrointestinal tract malignancies [1,2]. It is more common in immunocompromised patients and smokers . Rise of incidence over past decades  can be attributed to the increased prevalence of HPV infection which is the most important cause [3,5]. Abdominoperineal resection was the main treatment in the past, but resulted in suboptimal locoregional control and high morbidity due to sphincter loss . Following encouraging first experience with chemoradiation [7,8], its effectiveness was confirmed by several retrospective and phase II studies [9–13].
- Prostate brachytherapy is a highly effective treatment for localised prostate cancer in patients who have no evidence of metastases. It is indicated in two settings:
- Mature results from randomised trials of external beam radiotherapy (EBRT) show that biochemical control of disease improves with increasing radiation dose [1–4]. High-dose-rate afterloading brachytherapy (HDR-BT) can deliver a high, localised radiation dose to the prostate with excellent biochemical control of disease and has advantages over external beam radiotherapy (EBRT) because of its ability to overcome problems of organ movement, which confound the external beam techniques used [5–7] despite modern image guided approaches.
- The aim of this publication is to compile available literature data and expert experience regarding skin brachytherapy (BT) in order to produce general recommendations on behalf of the GEC-ESTRO Group.
- Online delineation workshops (ODW) permit training of geographically dispersed participants. The purpose is to evaluate the methodology of an ODW using FALCON to harmonize delineation within a European multicentre trial on locally advanced cervical cancer (LACC).
- Dual energy CT (DECT) scanners are nowadays available in many radiology departments. For radiotherapy purposes, new strategies using DECT imaging are investigated to optimize radiation treatment for multiple steps in the radiotherapy chain. This review describes how DECT based methods can be used for electron density estimation, effective atomic number decomposition and contrast material quantification. Clinical radiotherapy related applications for improved dose calculation accuracy of brachytherapy and proton therapy, metal artifact reduction techniques and normal tissue characterization are also summarized together with future perspectives on the use of DECT for radiotherapy purposes.