Editor-in-Chief Emeritus Pick of Papers
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For each issue of Radiotherapy and Oncology, the Editor-in-Chief Emeritus Jens Overgaard, picks his favourite papers.
- The internal mammary nodes (IMN) receive lymphatic drainage from all quadrants of the breast [1–5], with predominant drainage to IMNs in case of inner quadrant and deeply located nonpalpable tumours . Among patients who have pathologically node-negative axillary disease, up to 10% may have IMN tumour involvement, which increases to almost 40% in case of involved positive axillary nodes [1–6]. IMN dissection was not shown to provide survival benefit . For many years thereafter, elective IMN irradiation was controversial, as data were conflicting for disease outcome benefits vs potential detrimental effects of radiation therapy (RT) [7,8].
- Delineation of target and ‘organ at risk’ volumes is a critical part of modern radiation therapy planning, the next essential step after deciding the indication, patient discussion and image acquisition. Adoption of volume-based treatment planning for non-metastatic breast cancer has increased greatly along with the use of improved planning techniques, essential for modern therapy. However, identifying the volumes on a planning CT is no easy task. The current paper is written by ESTRO’s breast course faculty, providing tricks and tips for target volume definition and delineation for optimal postoperative breast cancer irradiation.
- In the Young Boost trial (YBT), breast cancer patients ≤50 years of age, treated with breast conserving therapy (BCT) were randomized between a 26 Gy boost dose and a 16 Gy boost dose, with local recurrence as primary and cosmetic outcome (CO) as secondary endpoint. Data of the YBT was used to investigate which factors are related with worse cosmetic outcome after BCT.
- Delineation of clinical target volumes (CTVs) is a weak link in radiation therapy (RT), and large inter-observer variation is seen in breast cancer patients. Several guidelines have been proposed, but most result in larger CTVs than based on conventional simulator-based RT. The aim was to develop a delineation guideline obtained by consensus between a broad European group of radiation oncologists.
- Disconnected cancer research data management and lack of information exchange about planned and ongoing research are complicating the utilisation of internationally collected medical information for improving cancer patient care. Rapidly collecting/pooling data can accelerate translational research in radiation therapy and oncology. The exchange of study data is one of the fundamental principles behind data aggregation and data mining. The possibilities of reproducing the original study results, performing further analyses on existing research data to generate new hypotheses or developing computational models to support medical decisions (e.g.