Editor-in-Chief Emeritus Pick of Papers
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For each issue of Radiotherapy and Oncology, the Editor-in-Chief Emeritus Jens Overgaard, picks his favourite papers.
- The DBCG 82bc randomized trial recruited between 1982 and 1990 3083 patients in a clinical trial to address the importance of postmastectomy radiotherapy (PMRT) to high-risk breast cancer patients who also received adjuvant systemic treatment [1,2]. The trial was initiated at a time where the role of local tumor control was heavily debated in the light of the potential importance of controlling a nidus for subsequent disseminated disease. The study therefore challenged the Alternative Hypothesis formulated by the late Bernard Fisher as an alternative to the original Halstedian Hypothesis, which states that tumors spread in an orderly defined manner, and that the extent and nuances of the loco-regional treatment are the dominant factors influencing patient outcome .
- Worldwide, approximately 710,000 patients are diagnosed annually with head and neck cancer (HNC) [1,2].
- The Danish Head and Neck Cancer Group (DAHANCA) was founded in 1976. Over the years the group successfully conducted clinical trials and has developed national guidelines for all aspects of the treatment of head and neck cancer. The first national recommendations for radiotherapy was included as an appendix to the DAHANCA 2 and DAHANCA 5 protocols [1,2] in 1979 and 1986, respectively. A thorough description of doses and treatment fields were in 1991 included in the large DAHANCA 6&7 randomized trial  and later in the DAHANCA 9 protocol .
- Evaluate the prognostic and predictive impact of HPV-associated p16-expression and assess the combined prognostic impact of p16 and smoking on altered fractionated radiotherapy (AFRT) for oropharyngeal cancer (OPC) within the frames of the update of the Meta-Analysis of Radiotherapy in Carcinomas of Head and neck (MARCH).
- To describe long-term failure pattern after early-stage breast cancer in relation to local treatment (breast-conserving therapy (BCT) or mastectomy) and age.
- The DAHANCA 6 trial evaluated tumor response and morbidity after moderate accelerated radiotherapy compared to conventional fractionated radiotherapy in patients treated for glottic squamous cell carcinoma (SCC). Further, the failure pattern and incidence of new primary tumors were explored.
- A 15-gene hypoxia profile has previously demonstrated to have both prognostic and predictive impact for hypoxic modification in squamous cell carcinoma of the head and neck. This gene expression profile may also have a prognostic value in other histological cancer types, and could potentially have a function as a universal hypoxia profile. The hypoxia induced upregulation of the included genes, and the validity of the previously used reference genes was established in this study, in a range of different cell lines representing carcinomas of the prostate, colon, and esophagus.
- HPV is found in head and neck cancer from all sites with a higher prevalence in oropharynx cancer (OPC) compared to non-OPC. HPV/p16-status has a significant impact on radiotherapy (RT) outcome in advanced OPC, but less is known about the influence in non-OPC. We analyzed HPV-associated p16-expression in a cohort of patients with stage III–IV pharynx and larynx cancer treated with primary, curatively intended (chemo-)RT, aiming to test the hypothesis that the impact of HPV/p16 also extends to tumors of non-oropharyngeal origin.
- Background and purpose: Radiotherapy for breast cancer both decreases loco-regional recurrence rates and improves overall survival. However, radiotherapy has also been associated with increased second cancer risk at exposed sites. In this meta-analysis, we estimated the risk of second non-breast cancers after radiotherapy for breast cancer. Material and methods: The databases Medline/Pubmed, Cochrane, Embase and Cinahl were systematically searched, for cohort studies on second cancer after radiotherapy for breast cancer, from inception to August 1st 2013.