Editor-in-Chief Emeritus Pick of Papers
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For each issue of Radiotherapy and Oncology, the Editor-in-Chief Emeritus Jens Overgaard, picks his favourite papers.
- Hepatocellular carcinoma (HCC) is a raising condition both world-wide and in Europe, already being one of the leading causes of cancer-specific deaths. Particular characteristics of the disease associated with its location in the liver and mixed etiology remain a challenge. Surgery, both liver resection and liver transplant, is the recommended curative treatment for the eligible patients. However, presence of cirrhosis, localization and extent of the tumor, performance status and comorbidities limit the number of qualifying patients.
- For unbiased comparison of different radiation modalities and techniques, consensus on delineation of radiation sensitive organs at risk (OARs) and on their dose constraints is warranted. Following the publication of a digital, online atlas for OAR delineation in neuro-oncology by the same group, we assessed the brain OAR-dose constraints in a follow-up study.
- A 15-gene hypoxia profile has previously demonstrated to have both prognostic and predictive impact for hypoxic modification in squamous cell carcinoma of the head and neck. This gene expression profile may also have a prognostic value in other histological cancer types, and could potentially have a function as a universal hypoxia profile. The hypoxia induced upregulation of the included genes, and the validity of the previously used reference genes was established in this study, in a range of different cell lines representing carcinomas of the prostate, colon, and esophagus.