Editor-in-Chief Emeritus Pick of Papers
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For each issue of Radiotherapy and Oncology, the Editor-in-Chief Emeritus Jens Overgaard, picks his favourite papers.
- Patients with locally advanced head and neck squamous cell carcinoma (HNSCC) are currently treated with postoperative radio-chemotherapy (PORT-C) or primary radio-chemotherapy. While the inclusion of chemotherapy improved the outcome significantly [1,2], treatment response is still heterogeneous. To further individualize therapy in order to improve treatment response, additional biomarkers need to be identified and applied in personalized treatment escalation or de-escalation strategies [3,4].
- Breast-conserving surgery (BCS) and adjuvant whole breast irradiation (WBI) has become the standard-therapy for early-stage breast cancer with equivalent overall survival and local control rates compared to mastectomy [1–3]. For further improvement of local control in younger patients or patients with high-risk tumors, an additional boost irradiation to the former tumor bed is recommended, which is usually delivered sequentially . However, with techniques like intensity-modulated radiotherapy (IMRT) a simultaneously integrated boost (SIB) may be applied.
- To evaluate outcome in patients with base of skull meningiomas treated with modern high precision radiation therapy (RT) techniques.
- To investigate the impact of HPV status in patients with locally advanced head and neck squamous cell carcinoma (HNSCC), who received surgery and cisplatin-based postoperative radiochemotherapy.
- Disconnected cancer research data management and lack of information exchange about planned and ongoing research are complicating the utilisation of internationally collected medical information for improving cancer patient care. Rapidly collecting/pooling data can accelerate translational research in radiation therapy and oncology. The exchange of study data is one of the fundamental principles behind data aggregation and data mining. The possibilities of reproducing the original study results, performing further analyses on existing research data to generate new hypotheses or developing computational models to support medical decisions (e.g.