Editor-in-Chief Emeritus Pick of Papers
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For each issue of Radiotherapy and Oncology, the Editor-in-Chief Emeritus Jens Overgaard, picks his favourite papers.
- The internal mammary nodes (IMN) receive lymphatic drainage from all quadrants of the breast [1–5], with predominant drainage to IMNs in case of inner quadrant and deeply located nonpalpable tumours . Among patients who have pathologically node-negative axillary disease, up to 10% may have IMN tumour involvement, which increases to almost 40% in case of involved positive axillary nodes [1–6]. IMN dissection was not shown to provide survival benefit . For many years thereafter, elective IMN irradiation was controversial, as data were conflicting for disease outcome benefits vs potential detrimental effects of radiation therapy (RT) [7,8].
- Patients with locally advanced head and neck squamous cell carcinoma (HNSCC) are currently treated with postoperative radio-chemotherapy (PORT-C) or primary radio-chemotherapy. While the inclusion of chemotherapy improved the outcome significantly [1,2], treatment response is still heterogeneous. To further individualize therapy in order to improve treatment response, additional biomarkers need to be identified and applied in personalized treatment escalation or de-escalation strategies [3,4].
Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelinesFew studies have reported large inter-observer variations in target volume selection and delineation in patients treated with radiotherapy for head and neck squamous cell carcinoma. Consensus guidelines have been published for the neck nodes (see Grégoire et al., 2003, 2014), but such recommendations are lacking for primary tumour delineation. For the latter, two main schools of thoughts are prevailing, one based on geometric expansion of the Gross Tumour Volume (GTV) as promoted by DAHANCA, and the other one based on anatomical expansion of the GTV using compartmentalization of head and neck anatomy.
- To investigate the impact of HPV status in patients with locally advanced head and neck squamous cell carcinoma (HNSCC), who received surgery and cisplatin-based postoperative radiochemotherapy.
- Disconnected cancer research data management and lack of information exchange about planned and ongoing research are complicating the utilisation of internationally collected medical information for improving cancer patient care. Rapidly collecting/pooling data can accelerate translational research in radiation therapy and oncology. The exchange of study data is one of the fundamental principles behind data aggregation and data mining. The possibilities of reproducing the original study results, performing further analyses on existing research data to generate new hypotheses or developing computational models to support medical decisions (e.g.