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FLASH Radiotherapy & Particle Therapy conference, FRPT2021

      The FLASH Radiotherapy & Particle Therapy conference [

      Abstracts of the FLASH Radiotherapy and Particle Therapy Conference, Phys Medica 2022;94:S1–S132.

      ], held 1st-3rd December 2021 (FRPT2021) was initially organized to be in-person in Vienna, Austria. However, it was instead held online, following shutdown of Austrian borders due to COVID-19 shortly before the event. FRPT2021 aimed to support the growth of a worldwide community of scientists and professionals interested in FLASH radiotherapy using protons, electrons, heavier charged ions and photons. It brought together researchers and students with professionals working in clinical oncology and provided a multidisciplinary forum to discuss the latest advancements in this rapidly developing field. The main topics were FLASH radiation modalities, FLASH mechanisms and FLASH in the clinic, so covering basic science, through preclinical research and combining these with translational applications, treatment methods and clinical trials. FRPT2021 was developed in collaboration with EU projects UHDpulse (http://uhdpulse-empir.eu/) [
      • Schüller A.
      • Heinrich S.
      • Fouillade C.
      • Subeil A.
      • De Marzi L.
      • Romano F.
      • et al.
      The European Joint Research Project UHDpulse – Metrology for advanced radiotherapy using particle beams with ultra-high pulse dose rates.
      ] and INSPIRE [https://protonsinspire.eu/].
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      References

      1. Abstracts of the FLASH Radiotherapy and Particle Therapy Conference, Phys Medica 2022;94:S1–S132.

        • Schüller A.
        • Heinrich S.
        • Fouillade C.
        • Subeil A.
        • De Marzi L.
        • Romano F.
        • et al.
        The European Joint Research Project UHDpulse – Metrology for advanced radiotherapy using particle beams with ultra-high pulse dose rates.
        Phys Medica. 2020; 80: 134-150
        • Bourhis J.
        • Montay-Gruel P.
        • Jorge P.G.
        • Bailat C.
        • Petit B.
        • Ollivier J.
        • et al.
        Clinical translation of FLASH radiotherapy: why and how?.
        Radiotherapy Oncol. 2019; 139: 11-17
        • Prezado Y.
        Divide and conquer: spatially fractionated radiation therapy.
        Expert Rev Mol Med. 2022; 24: 12
        • Schneider T.
        • Fernandez-Paloma C.
        • Bertho A.
        • Fazzari J.
        • Iturri L.
        • Martin O.A.
        • et al.
        Combining FLASH and spatially fractionated radiotherapy: the best of both worlds.
        Radiother Oncol. 2022; 175: 169-177
        • Singers Sørensen B.
        • Sitarz M.K.
        • Ankjaergaard C.
        • Johansen J.G.
        • Andersen C.E.
        • Kanouta E.
        • et al.
        Pencil beam scanning proton FLASH maintains tumor control while normal tissue damage is reduced in a mouse model.
        Radiother Oncol. 2022; 175: 178-184
        • Tinganelli W.
        • Weber U.
        • Puspitasari A.
        • Simoniello P.
        • Abdollahi A.
        • Oppermann J.
        • et al.
        FLASH with carbon ions: tumor control, normal tissue sparing and distal metastasis in a mouse osteosarcoma model.
        Radiother Oncol. 2022; 175: 185-190
        • Dubois L.J.
        • Commentary on the article Sørensen B.S.
        • et al.
        Pencil beam scanning proton FLASH maintains tumor control while normal tissue damage is reduced in a mouse model.
        Radiother Oncol. 2022; 175: 191-192
        • Ha B.
        • Liang K.
        • Liu C.
        • Melemenidis S.
        • Manjappa R.
        • Viswanathan V.
        • et al.
        Real-time optical oximetry during FLASH radiotherapy using a phosphorescent nanoprobe.
        Radiother Oncol. 2022; (this issue)
        • Jansen J.
        • Beyreuther E.
        • Garcia-Calderon D.
        • Karsch L.
        • Knoll J.
        • Pawelke J.
        • et al.
        Changes in radical levels as a cause for the FLASH effect: impact of beam structure parameters at ultra-high dose rates on oxygen depletion in water.
        Radiother Oncol. 2022; 175: 193-196
        • Karsch L.
        • Pawelke J.
        • Brand M.
        • Hans S.
        • Hideghety K.
        • Jansen J.
        • et al.
        Beam pulse structure and dose rate as determinants for the flash effect observed in zebrafish embryo.
        Radiother Oncol. 2022; 173: 49-54
        • Kacem H.
        • Psoroulas S.
        • Boivin G.
        • Folkerts M.
        • Grilj V.
        • Lomax T.
        • et al.
        Comparing radiolytic production of H2O2 and development of zebrafish embryos after ultra high dose rate exposure with electron and transmission proton beams.
        Radiother Oncol. 2022; 173: 197-202
        • Jorge P.G.
        • Melemenidis S.
        • Grilj V.
        • Buchillier T.
        • Manjappa R.
        • Viswanathan V.
        • et al.
        Design and validation of a dosimetric comparison scheme tailored for ultra-high dose-rate electron beams to support multicenter FLASH preclinical studies.
        Radiother Oncol. 2022; 175: 203-209
        • Rahman M.
        • Trigilio A.
        • Franciosini G.
        • Moeckli R.
        • Zang R.
        • et al.
        FLASH radiotherapy treatment planning and models for electron beams.
        Radiother Oncol. 2022; 175: 210-221
        • Rothwell B.
        • Lowe M.
        • Traneus E.
        • Krieger M.
        • Schuemann J.
        Treatment planning considerations for the development of FLASH proton therapy.
        Radiother Oncol. 2022; 175: 222-230
        • Habraken S.
        • Breedveld S.
        • Groen J.
        • Nuyttens J.
        • Hoogeman M.
        Trade off in healthy tissue sparing and fractionation in stereotactic proton therapy of lung lesions with transmission beams.
        Radiother Oncol. 2022; 175: 231-237
        • Wei S.
        • Lin H.
        • Choi J.I.
        • Chi C.
        • Simone C.B.
        • Kang M.
        Advanced pencil beam scanning Bragg peak FLASH-RT delivery techniques can enhance lung cancer planning treatment outcomes compared to conventional multiple-energy proton PBS techniques.
        Radiother Oncol. 2022; 175: 238-247
        • Rohrer Bley C.
        • Wolf F.
        • Gonçalves Jorge P.
        • Grilj V.
        • Petridis I.
        • Petit B.
        • et al.
        Dose and volume limiting late toxicity of FLASH radiotherapy in cats with squamous cell carcinoma of the nasal planum and in mini-pigs.
        Clin Cancer Res. 2022; 28: 3814-3823
        • Chabi S.
        • To T.H.V.
        • Leavitt R.
        • Poglio S.
        • Gonçalves Jorge P.
        • et al.
        Ultra-high dose rate FLASH and conventional dose rate irradiation differentially affect human acute lymphoblastic leukemia and normal hematopoiesis.
        Int J Rad Oncol Biol Phys. 2021; 109: 819-829
        • Vozenin M.-C.
        • Baumann M.
        • Coppes R.P.
        • Bourhis J.
        FLASH radiotherapy international workshop.
        Radiother Oncol. 2019; 139: 1-3