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A neuropathic component of tumor-related pain as a predictor of good response to palliative radiotherapy

      The recently published ESTRO ACROP guidelines for external beam radiotherapy in patients with uncomplicated [

      van der Velden J, Willmann J, Spałek M, Oldenburger E, Brown S, Kazmierska J, et al. ESTRO ACROP guidelines for external beam radiotherapy of patients with uncomplicated bone metastases. Radiother Oncol 2022;173:197–206.

      ] and complicated [

      Oldenburger E, Brown S, Willmann J, van der Velden JM, Spalek M, van der Linden YM, et al. ESTRO ACROP guidelines for external beam radiotherapy of patients with complicated bone metastases. Radiother Oncol 2022;173:240–253.

      ] bone metastases will have a major impact on radiotherapy practice for bone metastases. The guidelines for complicated bone metastases state that most studies demonstrating the benefit of radiotherapy in reducing bone metastasis-related pain fail to differentiate the type of pain experienced by patients [

      Oldenburger E, Brown S, Willmann J, van der Velden JM, Spalek M, van der Linden YM, et al. ESTRO ACROP guidelines for external beam radiotherapy of patients with complicated bone metastases. Radiother Oncol 2022;173:240–253.

      ]. The guidelines also state that there is no comparative evidence to evaluate the relative role of treatments such as medication, radiotherapy, and neurostimulation therapy, and hence, no recommendation can be provided regarding the use of radiotherapy [

      Oldenburger E, Brown S, Willmann J, van der Velden JM, Spalek M, van der Linden YM, et al. ESTRO ACROP guidelines for external beam radiotherapy of patients with complicated bone metastases. Radiother Oncol 2022;173:240–253.

      ].
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      References

      1. van der Velden J, Willmann J, Spałek M, Oldenburger E, Brown S, Kazmierska J, et al. ESTRO ACROP guidelines for external beam radiotherapy of patients with uncomplicated bone metastases. Radiother Oncol 2022;173:197–206.

      2. Oldenburger E, Brown S, Willmann J, van der Velden JM, Spalek M, van der Linden YM, et al. ESTRO ACROP guidelines for external beam radiotherapy of patients with complicated bone metastases. Radiother Oncol 2022;173:240–253.

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