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Radiosensitization by gold nanoparticles: Will they ever make it to the clinic?

  • Lei Cui
    Affiliations
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Canada
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  • Sohyoung Her
    Affiliations
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Canada
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  • Gerben R. Borst
    Affiliations
    Department of Radiation Oncology, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
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  • Robert G. Bristow
    Affiliations
    Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Canada

    Ontario Cancer Institute/Princess Margaret Cancer Centre, University Health Network, Toronto, Canada

    STTARR Innovation Centre, Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada
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  • David A. Jaffray
    Affiliations
    Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Canada

    STTARR Innovation Centre, Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada

    TECHNA Institute and Department of Radiation Physics, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada

    Department of Radiation Physics, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada

    Techna Institute, University Health Network, Toronto, Canada

    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Canada
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  • Christine Allen
    Correspondence
    Corresponding author at: Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario M5S 3M2, Canada.
    Affiliations
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Canada

    STTARR Innovation Centre, Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada

    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Canada
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      Abstract

      The utilization of gold nanoparticles (AuNPs) as radiosensitizers has shown great promise in pre-clinical research. In the current review, the physical, chemical, and biological pathways via which AuNPs enhance the effects of radiation are presented and discussed. In particular, the impact of AuNPs on the 5 Rs in radiobiology, namely repair, reoxygenation, redistribution, repopulation, and intrinsic radiosensitivity, which determine the extent of radiation enhancement effects are elucidated. Key findings from previous studies are outlined. In addition, crucial parameters including the physicochemical properties of AuNPs, route of administration, dosing schedule of AuNPs and irradiation, as well as type of radiation therapy, are highlighted; the optimal selection and combination of these parameters enable the achievement of a greater therapeutic window for AuNP sensitized radiotherapy. Future directions are put forward as a means to provide guidelines for successful translation of AuNPs to clinical applications as radiosensitizers.

      Keywords

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