The study selection process is shown in
Suppl. Fig. 1. Among 501 relevant publications on SBRT and 113 relevant publications on PBT, 205 full text articles for SBRT and 19 full text articles for hypo-fractionated PBT (proton and carbon ion therapy) were assessed for eligibility. Of these, 72 studies on photon SBRT and 9 studies on PBT for ES NSCLC were selected [
10- Onishi H.
- Shirato H.
- Nagata Y.
- Hiraoka M.
- Fujino M.
- Gomi K.
- et al.
Stereotactic body radiotherapy (SBRT) for operable stage I non-small-cell lung cancer: can SBRT be comparable to surgery?.
,
12- Chang J.
- Senan S.
- Paul M.A.
- Mehran R.J.
- Louie A.V.
- Balter P.
- et al.
Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer: a pooled analysis of two randomised trials.
,
20- Timmerman R.
- Paulus R.
- Galvin J.
- Michalski J.
- Straube W.
- Bradley J.
- et al.
Stereotactic body radiation therapy for inoperable early stage lung cancer.
,
21- Timmerman R.D.
- Hu C.
- Michalski J.
- Straube W.
- Galvin J.
- Johnstone D.
- et al.
Long-term results of RTOG 0236: a phase II trial of stereotactic body radiation therapy (SBRT) in the treatment of patients with medically inoperable stage I non-small cell lung cancer.
,
22- Videtic G.M.
- Hu C.
- Singh A.K.
- Chang J.Y.
- Parker W.
- Olivier K.R.
- et al.
A randomized phase 2 study comparing 2 stereotactic body radiation therapy schedules for medically inoperable patients with stage I peripheral non-small cell lung cancer: NRG Oncology RTOG 0915 (NCCTG N0927).
,
23- Fakiris A.J.
- McGarry R.C.
- Yiannoutsos C.T.
- Papiez L.
- Williams M.
- Henderson M.A.
- et al.
Stereotactic body radiation therapy for early-stage non-small-cell lung carcinoma: four-year results of a prospective phase II study.
,
24- Baumann P.
- Nyman J.
- Hoyer M.
- Wennberg B.
- Gagliardi G.
- Lax I.
- et al.
Outcome in a prospective phase II trial of medically inoperable stage I non-small-cell lung cancer patients treated with stereotactic body radiotherapy.
,
25- Lindberg K.
- Nyman J.
- Källskog V.R.
- Hoyer M.
- Lund J.Ǻ.
- Lax I.
- et al.
Long-term results of a prospective phase II trial of medically inoperable stage I NSCLC treated with SBRT – the Nordic experience.
,
26- Navarro-Martin A.
- Aso S.
- Cacicedo J.
- Arnaiz M.
- Navarro V.
- Rosales S.
- et al.
Phase II trial of SBRT for stage I NSCLC: survival, local control, and lung function at 36 months.
,
27- Bral S.
- Gevaert T.
- Linthout N.
- Versmessen H.
- Collen C.
- Engels B.
- et al.
Prospective, risk-adapted strategy of stereotactic body radiotherapy for early-stage non-small-cell lung cancer: results of a phase II trial.
,
28- Ricardi U.
- Filippi A.R.
- Guarneri A.
- Giglioli F.R.
- Ciammella P.
- Franco P.
- et al.
Stereotactic body radiation therapy for early stage non-small cell lung cancer: results of a prospective trial.
,
29- Nagata Y.
- Hiraoka M.
- Shibata T.
- Onishi H.
- Kokubo M.
- Karasawa K.
- et al.
Prospective trial of stereotactic body radiation therapy for both operable and inoperable T1N0M0 non-small cell lung cancer: Japan Clinical Oncology Group Study JCOG0403.
,
30- Koto M.
- Takai Y.
- Ogawa Y.
- Matsushita H.
- Takeda K.
- Takahashi C.
- et al.
A phase II study on stereotactic body radiotherapy for stage I non-small cell lung cancer.
,
31- Onishi H.
- Kuriyama K.
- Komiyama T.
- Tanaka S.
- Sano N.
- Marino K.
- et al.
Clinical outcomes of stereotactic radiotherapy for stage I non-small cell lung cancer using a novel irradiation technique: patient self-controlled breath-hold and beam switching using a combination of linear accelerator and CT scanner.
,
32- Onimaru R.
- Shirato H.
- Shibata T.
- Hiraoka M.
- Ishikura S.
- Karasawa K.
- et al.
Phase I study of stereotactic body radiation therapy for peripheral T2N0M0 non-small cell lung cancer with PTV∗∗ 100 cc using a continual reassessment method (JCOG0702).
,
33- Chiang A.
- Thibault I.
- Warner A.
- Rodrigues G.
- Palma D.
- Soliman H.
- et al.
A comparison between accelerated hypofractionation and stereotactic ablative radiotherapy (SABR) for early-stage non-small cell lung cancer (NSCLC): results of a propensity score-matched analysis.
,
34- Taremi M.
- Hope A.
- Dahele M.
- Pearson S.
- Fung S.
- Purdie T.
- et al.
Stereotactic body radiotherapy for medically inoperable lung cancer: prospective, single-center study of 108 consecutive patients.
,
35- Mak R.H.
- Hermann G.
- Lewis J.H.
- Aerts H.J.W.L.
- Baldini E.H.
- Chen A.B.
- et al.
Outcomes by tumor histology and KRAS mutation status after lung stereotactic body radiation therapy for early-stage non-small-cell lung cancer.
,
36- Ebright M.I.
- Russo G.A.
- Gupta A.
- Subramaniam R.M.
- Fernando H.C.
- Kachnic L.A.
Positron emission tomography combined with diagnostic chest computed tomography enhances detection of regional recurrence after stereotactic body radiation therapy for early stage non-small cell lung cancer.
,
37- Park H.S.
- Harder E.M.
- Mancini B.R.
- Decker R.H.
Central versus peripheral tumor location: influence on survival, local control, and toxicity following stereotactic body radiotherapy for primary non-small-cell lung cancer.
,
38- Spratt D.E.
- Wu A.J.
- Adeseye V.
- Din S.U.
- Shaikh F.
- Woo K.M.
- et al.
Recurrence patterns and second primary lung cancers after stereotactic body radiation therapy for early-stage non-small-cell lung cancer: implications for surveillance.
,
39- Parashar B.
- Port J.
- Arora S.
- Christos P.
- Trichter S.
- Nori D.
- et al.
Analysis of stereotactic body radiation vs. wedge resection vs. wedge resection plus cesium-131 brachytherapy in early stage lung cancer.
,
40- Kelley K.D.
- Benninghoff D.L.
- Stein J.S.
- Li J.Z.
- Byrnes R.T.
- Potters L.
- et al.
Medically inoperable peripheral lung cancer treated with stereotactic body radiation therapy.
,
41- Vu C.C.
- Matthews R.
- Kim B.
- Franceschi D.
- Bilfinger T.V.
- Moore W.H.
Prognostic value of metabolic tumor volume and total lesion glycolysis from 18F-FDG PET/CT in patients undergoing stereotactic body radiation therapy for stage I non-small-cell lung cancer.
,
42- Horne Z.D.
- Clump D.A.
- Vargo J.A.
- Shah S.
- Beriwal S.
- Burton S.A.
- et al.
Pretreatment SUVmax predicts progression-free survival in early-stage non-small cell lung cancer treated with stereotactic body radiation therapy.
,
43- Vahdat S.
- Oermann E.K.
- Collins S.P.
- Yu X.
- Abedalthagafi M.
- DeBrito P.
- et al.
Cyberknife radiosurgery for inoperable stage IA non-small cell lung cancer: 18F-fluorodeoxyglucose positron emission tomography/computed tomography serial tumor response assessment.
,
44- Dunlap N.E.
- Larner J.M.
- Read P.W.
- Kozower B.D.
- Lau C.L.
- Sheng K.
- et al.
Size matters: a comparison of T1 and T2 peripheral non-small-cell lung cnacers treated with stereotactic body radiation therapy (SBRT).
,
45- Brown W.T.
- Wu X.
- Fayad F.
- Fowler J.F.
- García S.
- Monterroso M.I.
- et al.
Application of robotic stereotactic radiotherapy to peripheral stage I non-small cell lung cancer with curative intent.
,
46- Grills I.S.
- Hope A.J.
- Guckenberger M.
- Kestin L.L.
- Werner-Wasik M.
- Yan D.
- et al.
A collaborative analysis of stereotactic lung radiotherapy outcomes for early-stage non-small-cell lung cancer using daily online cone-beam computed tomography image-guided radiotherapy.
,
47- Videtic G.M.
- Stephans K.L.
- Woody N.M.
- Reddy C.A.
- Zhuang T.
- Magnelli A.
- et al.
30 Gy or 34 Gy? Comparing 2 single-fraction SBRT dose schedules for stage I medically inoperable non-small cell lung cancer.
,
48- Burdick M.J.
- Stephans K.L.
- Reddy C.A.
- Djemil T.
- Srinivas S.M.
- Videtic G.M.
Maximum standardized uptake value from staging FDG-PET/CT does not predict treatment outcome for early-stage non-small-cell lung cancer treated with stereotactic body radiotherapy.
,
49- Fischer-Valuck B.W.
- Boggs H.
- Katz S.
- Durci M.
- Acharya S.
- Rosen L.R.
Comparison of stereotactic body radiation therapy for biopsy-proven versus radiographically diagnosed early-stage non-small lung cancer: a single-institution experience.
,
50- Zhang X.
- Liu H.
- Balter P.
- Allen P.K.
- Komaki R.
- Pan T.
- et al.
Positron emission tomography for assessing local failure after stereotactic body radiotherapy for non-small-cell lung cancer.
,
51- Shultz D.B.
- Trakul N.
- Abelson J.A.
- Murphy J.D.
- Maxim P.G.
- Le Q.T.
- et al.
Imaging features associated with disease progression after stereotactic ablative radiotherapy for stage I non-small-cell lung cancer.
,
52- Trakul N.
- Chang C.N.
- Harris J.
- Chapman C.
- Rao A.
- Shen J.
- et al.
Tumor volume-adpated dosing in stereotactic ablative radiotherapy of lung tumors.
,
53- Shaverdian N.
- Veruttipong D.
- Wang J.
- Schaue D.
- Kupelian P.
- Lee P.
Pretreatment immune parameters predict for overall survival and toxicity in early-stage non-small-cell lung cancer patients treated with stereotactic body radiation therapy.
,
54- Nath S.K.
- Sandhu A.P.
- Kim D.
- Bharne A.
- Nobiensky P.D.
- Lawson J.D.
- et al.
Locoregional and distant failure following image-guided stereotactic body radiation for early-stage primary lung cancer.
,
55- Olsen J.R.
- Robinson C.G.
- El Naqa I.
- Creach K.M.
- Drzymala R.E.
- Parikh P.J.
- et al.
Dose-response for stereotactic body radiotherapy in early-stage non-small-cell lung cancer.
,
56- Richardi U.
- Frezza G.
- Filippi A.R.
- Badellino S.
- Levis M.
- Navarria P.
- et al.
Stereotactic ablative radiotherapy for stage I histologically proven non-small cell lung cancer: an Italian multicenter observational study.
,
57- Jeppesen S.S.
- Schytte T.
- Jensen H.R.
- Brink C.
- Hansen O.
Stereotactic body radiation therapy versus conventional radiation therapy in patients with early stage non-small cell lung cancer: an updated retrospective study on local failure and survival rates.
,
58- Guckenberger M.
- Allgäuer M.
- Appold S.
- Dieckmann K.
- Ernst I.
- Ganswindt U.
- et al.
Safety and efficacy of stereotactic body radiotherapy for stage I non-small-cell lung cancer in routine clinical practice.
,
59- Andratschke N.
- Zimmermann F.
- Boehm E.
- Schill S.
- Schoenknecht C.
- Thamm R.
- et al.
Stereotactic radiotherapy of histologically proven inoperable stage I non-small cell lung cancer: patterns of failure.
,
60- Kopeck N.
- Paludan M.
- Petersen J.
- Hansen A.T.
- Grau C.
- Høyer M.
Co-morbidity index predicts for mortality after stereotactic body radiotherapy for medically inoperable early-stage non-small cell lung cancer.
,
61- Nyman J.
- Johansson K.A.
- Hultén U.
Stereotactic hypofractionated radiotherapy for stage I non-small cell lung cancer – mature results for medically inoperable patients.
,
62- Kastelijn E.A.
- El Sharouni S.Y.
- Hofman F.N.
- Van Putte B.P.
- Monninkhof E.M.
- Van Vulpen M.
- et al.
Clinical outcomes in early-stage NSCLC treated with stereotactic body radiotherapy versus surgical resection.
,
63- Peulen H.
- Belderbos J.
- Rossi M.
- Sonke J.J.
Mid-ventilation based PTV margins in stereotactic body radiotherapy (SBRT): a clinical evaluation.
,
64- Senthi S.
- Lagerwaard F.J.
- Haasbeek C.J.A.
- Slotman B.J.
- Senan S.
Patterns of disease recurrence after stereotactic ablative radiotherapy for early stage non-small-cell lung cancer: a retrospective analysis.
,
65Van der Voort van Zyp NC, Prévost JB, Hoogeman MS, Praag J, van der Holt B, Levendag PC, et al. Stereotactic radiotherapy with real-time tumor tracking for non-small cell lung cancer: clinical outcome. 2009; 91: 296 - 300.
,
66- Lovinfosse P.
- Janvary Z.L.
- Coucke P.
- Jodogne S.
- Bernard C.
- Hatt M.
- et al.
FDG PET/CT texture analysis for predicting the outcome of lung cancer treated by stereotactic body radiation therapy.
,
67- Janssen S.
- Kaesmann L.
- Rudat V.
- Rades D.
Stereotactic body radiotherapy (SBRT) with lower doses for selected patients with stage I non-small-cell lung cancer (NSCLC).
,
68- Duncker-Rohr V.
- Nestle U.
- Momm F.
- Prokic V.
- Heinemann F.
- Mix M.
- et al.
Stereotactic ablative radiotherapy for small lung tumors with a moderate dose. Favorable results and low toxicity.
,
69- Fritz P.
- Kraus H.J.
- Blaschke T.
- Mühlnickel W.
- Strauch K.
- Engel-Riedel W.
- et al.
Stereotactic, high single-dose irradiation of stage I non-small cell lung cancer (NSCLC) using four-dimensional CT scans for treatment planning.
,
70- Hof H.
- Muenter M.
- Oetzel D.
- Hoess A.
- Debus J.
- Herfarth K.
Stereotactic single-dose radiotherapy (radiosurgery) of early stage nonsmall-cell lung cancer (NSCLC).
,
71- Wulf J.
- Haedinger U.
- Oppitz U.
- Thiele W.
- Mueller G.
- Flentje M.
Stereotactic radiotherapy for primary lung cancer and pulmonary metastases: a noninvasive treatment approach in medically inoperable patients.
,
72- Scorsetti M.
- Navarria P.
- Facoetti A.
- Lattuada P.
- Urso G.
- Mirandola A.
- et al.
Effectiveness of stereotactic body radiotherapy in the treatment of inoperable early-stage lung cancer.
,
73- Onishi H.
- Shirato H.
- Nagata Y.
- Hiraoka M.
- Fujino M.
- Gomi K.
- et al.
Hypofractionated stereotactic radiotherapy (HypoFXSRT) for stage I non-small cell lung cancer: updated results of 257 patients in a Japanese multi-institutional study.
,
74- Tsurugai Y.
- Kozuka T.
- Ishizuka N.
- Oguchi M.
Relationship between the consolidation to maximum tumor diameter ratio and outcomes following stereotactic body radiotherapy for stage I non-small-cell lung cancer.
,
75- Hayashi S.
- Tanaka H.
- Hoshi H.
Imaging characteristics of local recurrences after stereotactic body radiation therapy for stage I non-small cell lung cancer: evaluation of mass-like fibrosis.
,
76- Shibamoto Y.
- Hashizume C.
- Baba F.
- Ayakawa S.
- Miyakawa A.
- Murai T.
- et al.
Stereotactic body radiotherapy using a radiobiology-based regimen for stage I non-small-cell lung cancer.
,
77- Yamamoto T.
- Kadoya N.
- Shirata Y.
- Koto M.
- Sato K.
- Matsushita H.
- et al.
Impact of tumor attachment to the pleura measured by a pretreatment CT image on outcome of stage I NSCLC treated with stereotactic body radiotherapy.
,
78- Yoshitake T.
- Nakamura K.
- Shioyama Y.
- Sasaki T.
- Ohga S.
- Shinoto M.
- et al.
Stereotactic body radiation therapy for primary lung cancers clinically diagnosed without pathological confirmation: a single-institution experience.
,
79- Satoh Y.
- Onishi H.
- Nambu A.
- Araki T.
Volume-based parameters measured by using FDG PET/CT in patients with stage I NSCLC treated with stereotactic body radiation therapy: prognostic value.
,
80- Yamashita H.
- Haga A.
- Takahashi W.
- Takenaka R.
- Imae T.
- Takenaka S.
- et al.
Volumetric modulated arc therapy for lung stereotactic radiation therapy can achieve high local control rates.
,
81- Inoue T.
- Katoh N.
- Onimaru R.
- Shimizu S.
- Tsuchiya K.
- Suzuki R.
- et al.
Stereotactic body radiotherapy using gated radiotherapy with real-time tumor-tracking for stage I non-small cell lung cancer.
,
82- Matsuo Y.
- Shibuya K.
- Nagata Y.
- Takayama K.
- Norihisa Y.
- Mizowaki T.
- et al.
Prognostic factors in stereotactic body radiotherapy for non-small-cell lung cancer.
,
83- Hamamoto Y.
- Kataoka M.
- Yamashita M.
- Shinkai T.
- Kubo Y.
- Sugawara Y.
- et al.
Local control of metastatic lung tumors treated with SBRT of 48 Gy in four fractions: in comparison with primary lung cancer.
,
84- Shen Z.T.
- Wu X.H.
- Li B.
- Zhu X.X.
Clinical outcomes of cyberknife stereotactic body radiotherapy for peripheral stage I non-small cell lung cancer.
,
85- Wu D.
- Zhu H.
- Tang H.
- Li C.
- Xu F.
Clinical analysis of stereotactic body radiation therapy using extracranial gamma knife for patients with mainly bulky inoperable early stage non-small cell lung carcinoma.
,
86- Ng A.W.
- Tung S.Y.
- Wong V.Y.
Hypofractionated stereotactic radiotherapy for medically inoperable stage I non-small cell lung cancer-report on clinical outcome and dose to critical organs.
,
87- Xia T.
- Li H.
- Sun Q.
- Wang Y.
- Fan N.
- Yu Y.
- et al.
Promising clinical outcome of stereotactic body radiation therapy for patients with inoperable stage I/II non-small-cell lung cancer.
,
88- Kim M.J.
- Yeo S.G.
- Kim E.S.
- Min C.K.
- Se An P.
Intensity-modulated stereotactic body radiotherapy for stage I non-small cell lung cancer.
,
89- Song S.Y.
- Choi W.
- Shin S.S.
- Lee S.W.
- Ahn S.D.
- Kim J.H.
- et al.
Fractionated stereotactic body radiation therapy for medically inoperable stage I lung cancer adjacent to central large bronchus.
,
90- Baba F.
- Shibamoto Y.
- Ogino H.
- Murata R.
- Sugie C.
- Iwata H.
- et al.
Clinical outcomes of stereotactic body radiotherapy for stage I non-small cell lung cancer using different doses depending on tumor size.
,
91- Bush D.A.
- Cheek G.
- Zaheer S.
- Wallen J.
- Mirshahidi H.
- Katerelos A.
- et al.
High-dose hypofractionated proton beam radiation therapy is safe and effective for central and peripheral early-stage non-small cell lung cancer: results of a 12-year experience at Loma Linda University Medical Center.
,
92- Miyamoto T.
- Baba M.
- Sugane T.
- Nakajima M.
- Yashiro T.
- Kagei K.
- et al.
Carbon ion radiotherapy for stage I non-small cell lung cancer using a regimen of four fractions during 1 week.
,
93- Miyamoto T.
- Baba M.
- Yamamoto N.
- Koto M.
- Sugawara T.
- Yashiro T.
- et al.
Curative treatment of stage I non-small-cell lung cancer with carbon ion beams using a hypofractionated regimen.
,
94- Karube M.
- Yamamoto N.
- Nakajima M.
- Yamashita H.
- Nakagawa K.
- Miyamoto T.
- et al.
Single-fraction carbon-ion radiation therapy for patients 80 years of age and older with stage I non-small cell lung cancer.
,
95- Westover K.D.
- Seco J.
- Adams J.A.
- Lanuti M.
- Choi N.C.
- Engelsman M.
- et al.
Proton SBRT for medically inoperable stage I NSCLC.
,
96- Hatayama Y.
- Nakamura T.
- Suzuki M.
- Azami Y.
- Ono T.
- Yabuuchi T.
- et al.
Clinical outcomes and prognostic factors of high-dose proton beam therapy for peripheral stage I non-small-cell lung cancer.
,
97- Kanemoto A.
- Okumura T.
- Ishikawa H.
- Mizumoto M.
- Oshiro Y.
- Kurishima K.
- et al.
Outcomes and prognostic factors for recurrence after high-dose proton beam therapy for centrally and peripherally located stage I non-small-cell lung cancer.
,
98- Fujii O.
- Demizu Y.
- Hashimoto N.
- Takagi M.
- Terashima K.
- Mima M.
- et al.
Particle therapy for clinically diagnosed stage I lung cancer: comparison with pathologically proven non-small cell lung cancer.
,
99- Fujii O.
- Demizu Y.
- Hashimoto N.
- Araya M.
- Takagi M.
- Terashima K.
- et al.
A retrospective comparison of proton therapy and carbon ion therapy for stage I non-small cell lung cancer.
]. Relevant information on the long term clinical outcome was also extracted from an abstract for 1 phase 2 SBRT trial [
20- Timmerman R.
- Paulus R.
- Galvin J.
- Michalski J.
- Straube W.
- Bradley J.
- et al.
Stereotactic body radiation therapy for inoperable early stage lung cancer.
,
21- Timmerman R.D.
- Hu C.
- Michalski J.
- Straube W.
- Galvin J.
- Johnstone D.
- et al.
Long-term results of RTOG 0236: a phase II trial of stereotactic body radiation therapy (SBRT) in the treatment of patients with medically inoperable stage I non-small cell lung cancer.
]. Two SBRT studies reporting the results of the same phase 2 trial complemented each other, and were counted as 1 study. One phase 3 study comparing SBRT and surgery (only the SBRT data was used) [
[12]- Chang J.
- Senan S.
- Paul M.A.
- Mehran R.J.
- Louie A.V.
- Balter P.
- et al.
Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer: a pooled analysis of two randomised trials.
], 10 phase 2 [
20- Timmerman R.
- Paulus R.
- Galvin J.
- Michalski J.
- Straube W.
- Bradley J.
- et al.
Stereotactic body radiation therapy for inoperable early stage lung cancer.
,
21- Timmerman R.D.
- Hu C.
- Michalski J.
- Straube W.
- Galvin J.
- Johnstone D.
- et al.
Long-term results of RTOG 0236: a phase II trial of stereotactic body radiation therapy (SBRT) in the treatment of patients with medically inoperable stage I non-small cell lung cancer.
,
22- Videtic G.M.
- Hu C.
- Singh A.K.
- Chang J.Y.
- Parker W.
- Olivier K.R.
- et al.
A randomized phase 2 study comparing 2 stereotactic body radiation therapy schedules for medically inoperable patients with stage I peripheral non-small cell lung cancer: NRG Oncology RTOG 0915 (NCCTG N0927).
,
23- Fakiris A.J.
- McGarry R.C.
- Yiannoutsos C.T.
- Papiez L.
- Williams M.
- Henderson M.A.
- et al.
Stereotactic body radiation therapy for early-stage non-small-cell lung carcinoma: four-year results of a prospective phase II study.
,
24- Baumann P.
- Nyman J.
- Hoyer M.
- Wennberg B.
- Gagliardi G.
- Lax I.
- et al.
Outcome in a prospective phase II trial of medically inoperable stage I non-small-cell lung cancer patients treated with stereotactic body radiotherapy.
,
25- Lindberg K.
- Nyman J.
- Källskog V.R.
- Hoyer M.
- Lund J.Ǻ.
- Lax I.
- et al.
Long-term results of a prospective phase II trial of medically inoperable stage I NSCLC treated with SBRT – the Nordic experience.
,
26- Navarro-Martin A.
- Aso S.
- Cacicedo J.
- Arnaiz M.
- Navarro V.
- Rosales S.
- et al.
Phase II trial of SBRT for stage I NSCLC: survival, local control, and lung function at 36 months.
,
27- Bral S.
- Gevaert T.
- Linthout N.
- Versmessen H.
- Collen C.
- Engels B.
- et al.
Prospective, risk-adapted strategy of stereotactic body radiotherapy for early-stage non-small-cell lung cancer: results of a phase II trial.
,
28- Ricardi U.
- Filippi A.R.
- Guarneri A.
- Giglioli F.R.
- Ciammella P.
- Franco P.
- et al.
Stereotactic body radiation therapy for early stage non-small cell lung cancer: results of a prospective trial.
,
29- Nagata Y.
- Hiraoka M.
- Shibata T.
- Onishi H.
- Kokubo M.
- Karasawa K.
- et al.
Prospective trial of stereotactic body radiation therapy for both operable and inoperable T1N0M0 non-small cell lung cancer: Japan Clinical Oncology Group Study JCOG0403.
,
30- Koto M.
- Takai Y.
- Ogawa Y.
- Matsushita H.
- Takeda K.
- Takahashi C.
- et al.
A phase II study on stereotactic body radiotherapy for stage I non-small cell lung cancer.
,
31- Onishi H.
- Kuriyama K.
- Komiyama T.
- Tanaka S.
- Sano N.
- Marino K.
- et al.
Clinical outcomes of stereotactic radiotherapy for stage I non-small cell lung cancer using a novel irradiation technique: patient self-controlled breath-hold and beam switching using a combination of linear accelerator and CT scanner.
], 1 phase 1 [
[32]- Onimaru R.
- Shirato H.
- Shibata T.
- Hiraoka M.
- Ishikura S.
- Karasawa K.
- et al.
Phase I study of stereotactic body radiation therapy for peripheral T2N0M0 non-small cell lung cancer with PTV∗∗ 100 cc using a continual reassessment method (JCOG0702).
], and 56 retrospective [
33- Chiang A.
- Thibault I.
- Warner A.
- Rodrigues G.
- Palma D.
- Soliman H.
- et al.
A comparison between accelerated hypofractionation and stereotactic ablative radiotherapy (SABR) for early-stage non-small cell lung cancer (NSCLC): results of a propensity score-matched analysis.
,
34- Taremi M.
- Hope A.
- Dahele M.
- Pearson S.
- Fung S.
- Purdie T.
- et al.
Stereotactic body radiotherapy for medically inoperable lung cancer: prospective, single-center study of 108 consecutive patients.
,
35- Mak R.H.
- Hermann G.
- Lewis J.H.
- Aerts H.J.W.L.
- Baldini E.H.
- Chen A.B.
- et al.
Outcomes by tumor histology and KRAS mutation status after lung stereotactic body radiation therapy for early-stage non-small-cell lung cancer.
,
36- Ebright M.I.
- Russo G.A.
- Gupta A.
- Subramaniam R.M.
- Fernando H.C.
- Kachnic L.A.
Positron emission tomography combined with diagnostic chest computed tomography enhances detection of regional recurrence after stereotactic body radiation therapy for early stage non-small cell lung cancer.
,
37- Park H.S.
- Harder E.M.
- Mancini B.R.
- Decker R.H.
Central versus peripheral tumor location: influence on survival, local control, and toxicity following stereotactic body radiotherapy for primary non-small-cell lung cancer.
,
38- Spratt D.E.
- Wu A.J.
- Adeseye V.
- Din S.U.
- Shaikh F.
- Woo K.M.
- et al.
Recurrence patterns and second primary lung cancers after stereotactic body radiation therapy for early-stage non-small-cell lung cancer: implications for surveillance.
,
39- Parashar B.
- Port J.
- Arora S.
- Christos P.
- Trichter S.
- Nori D.
- et al.
Analysis of stereotactic body radiation vs. wedge resection vs. wedge resection plus cesium-131 brachytherapy in early stage lung cancer.
,
40- Kelley K.D.
- Benninghoff D.L.
- Stein J.S.
- Li J.Z.
- Byrnes R.T.
- Potters L.
- et al.
Medically inoperable peripheral lung cancer treated with stereotactic body radiation therapy.
,
41- Vu C.C.
- Matthews R.
- Kim B.
- Franceschi D.
- Bilfinger T.V.
- Moore W.H.
Prognostic value of metabolic tumor volume and total lesion glycolysis from 18F-FDG PET/CT in patients undergoing stereotactic body radiation therapy for stage I non-small-cell lung cancer.
,
42- Horne Z.D.
- Clump D.A.
- Vargo J.A.
- Shah S.
- Beriwal S.
- Burton S.A.
- et al.
Pretreatment SUVmax predicts progression-free survival in early-stage non-small cell lung cancer treated with stereotactic body radiation therapy.
,
43- Vahdat S.
- Oermann E.K.
- Collins S.P.
- Yu X.
- Abedalthagafi M.
- DeBrito P.
- et al.
Cyberknife radiosurgery for inoperable stage IA non-small cell lung cancer: 18F-fluorodeoxyglucose positron emission tomography/computed tomography serial tumor response assessment.
,
44- Dunlap N.E.
- Larner J.M.
- Read P.W.
- Kozower B.D.
- Lau C.L.
- Sheng K.
- et al.
Size matters: a comparison of T1 and T2 peripheral non-small-cell lung cnacers treated with stereotactic body radiation therapy (SBRT).
,
45- Brown W.T.
- Wu X.
- Fayad F.
- Fowler J.F.
- García S.
- Monterroso M.I.
- et al.
Application of robotic stereotactic radiotherapy to peripheral stage I non-small cell lung cancer with curative intent.
,
46- Grills I.S.
- Hope A.J.
- Guckenberger M.
- Kestin L.L.
- Werner-Wasik M.
- Yan D.
- et al.
A collaborative analysis of stereotactic lung radiotherapy outcomes for early-stage non-small-cell lung cancer using daily online cone-beam computed tomography image-guided radiotherapy.
,
47- Videtic G.M.
- Stephans K.L.
- Woody N.M.
- Reddy C.A.
- Zhuang T.
- Magnelli A.
- et al.
30 Gy or 34 Gy? Comparing 2 single-fraction SBRT dose schedules for stage I medically inoperable non-small cell lung cancer.
,
48- Burdick M.J.
- Stephans K.L.
- Reddy C.A.
- Djemil T.
- Srinivas S.M.
- Videtic G.M.
Maximum standardized uptake value from staging FDG-PET/CT does not predict treatment outcome for early-stage non-small-cell lung cancer treated with stereotactic body radiotherapy.
,
49- Fischer-Valuck B.W.
- Boggs H.
- Katz S.
- Durci M.
- Acharya S.
- Rosen L.R.
Comparison of stereotactic body radiation therapy for biopsy-proven versus radiographically diagnosed early-stage non-small lung cancer: a single-institution experience.
,
50- Zhang X.
- Liu H.
- Balter P.
- Allen P.K.
- Komaki R.
- Pan T.
- et al.
Positron emission tomography for assessing local failure after stereotactic body radiotherapy for non-small-cell lung cancer.
,
51- Shultz D.B.
- Trakul N.
- Abelson J.A.
- Murphy J.D.
- Maxim P.G.
- Le Q.T.
- et al.
Imaging features associated with disease progression after stereotactic ablative radiotherapy for stage I non-small-cell lung cancer.
,
53- Shaverdian N.
- Veruttipong D.
- Wang J.
- Schaue D.
- Kupelian P.
- Lee P.
Pretreatment immune parameters predict for overall survival and toxicity in early-stage non-small-cell lung cancer patients treated with stereotactic body radiation therapy.
,
54- Nath S.K.
- Sandhu A.P.
- Kim D.
- Bharne A.
- Nobiensky P.D.
- Lawson J.D.
- et al.
Locoregional and distant failure following image-guided stereotactic body radiation for early-stage primary lung cancer.
,
55- Olsen J.R.
- Robinson C.G.
- El Naqa I.
- Creach K.M.
- Drzymala R.E.
- Parikh P.J.
- et al.
Dose-response for stereotactic body radiotherapy in early-stage non-small-cell lung cancer.
,
56- Richardi U.
- Frezza G.
- Filippi A.R.
- Badellino S.
- Levis M.
- Navarria P.
- et al.
Stereotactic ablative radiotherapy for stage I histologically proven non-small cell lung cancer: an Italian multicenter observational study.
,
57- Jeppesen S.S.
- Schytte T.
- Jensen H.R.
- Brink C.
- Hansen O.
Stereotactic body radiation therapy versus conventional radiation therapy in patients with early stage non-small cell lung cancer: an updated retrospective study on local failure and survival rates.
,
58- Guckenberger M.
- Allgäuer M.
- Appold S.
- Dieckmann K.
- Ernst I.
- Ganswindt U.
- et al.
Safety and efficacy of stereotactic body radiotherapy for stage I non-small-cell lung cancer in routine clinical practice.
,
59- Andratschke N.
- Zimmermann F.
- Boehm E.
- Schill S.
- Schoenknecht C.
- Thamm R.
- et al.
Stereotactic radiotherapy of histologically proven inoperable stage I non-small cell lung cancer: patterns of failure.
,
60- Kopeck N.
- Paludan M.
- Petersen J.
- Hansen A.T.
- Grau C.
- Høyer M.
Co-morbidity index predicts for mortality after stereotactic body radiotherapy for medically inoperable early-stage non-small cell lung cancer.
,
61- Nyman J.
- Johansson K.A.
- Hultén U.
Stereotactic hypofractionated radiotherapy for stage I non-small cell lung cancer – mature results for medically inoperable patients.
,
62- Kastelijn E.A.
- El Sharouni S.Y.
- Hofman F.N.
- Van Putte B.P.
- Monninkhof E.M.
- Van Vulpen M.
- et al.
Clinical outcomes in early-stage NSCLC treated with stereotactic body radiotherapy versus surgical resection.
,
63- Peulen H.
- Belderbos J.
- Rossi M.
- Sonke J.J.
Mid-ventilation based PTV margins in stereotactic body radiotherapy (SBRT): a clinical evaluation.
,
64- Senthi S.
- Lagerwaard F.J.
- Haasbeek C.J.A.
- Slotman B.J.
- Senan S.
Patterns of disease recurrence after stereotactic ablative radiotherapy for early stage non-small-cell lung cancer: a retrospective analysis.
,
65Van der Voort van Zyp NC, Prévost JB, Hoogeman MS, Praag J, van der Holt B, Levendag PC, et al. Stereotactic radiotherapy with real-time tumor tracking for non-small cell lung cancer: clinical outcome. 2009; 91: 296 - 300.
,
66- Lovinfosse P.
- Janvary Z.L.
- Coucke P.
- Jodogne S.
- Bernard C.
- Hatt M.
- et al.
FDG PET/CT texture analysis for predicting the outcome of lung cancer treated by stereotactic body radiation therapy.
,
67- Janssen S.
- Kaesmann L.
- Rudat V.
- Rades D.
Stereotactic body radiotherapy (SBRT) with lower doses for selected patients with stage I non-small-cell lung cancer (NSCLC).
,
68- Duncker-Rohr V.
- Nestle U.
- Momm F.
- Prokic V.
- Heinemann F.
- Mix M.
- et al.
Stereotactic ablative radiotherapy for small lung tumors with a moderate dose. Favorable results and low toxicity.
,
69- Fritz P.
- Kraus H.J.
- Blaschke T.
- Mühlnickel W.
- Strauch K.
- Engel-Riedel W.
- et al.
Stereotactic, high single-dose irradiation of stage I non-small cell lung cancer (NSCLC) using four-dimensional CT scans for treatment planning.
,
70- Hof H.
- Muenter M.
- Oetzel D.
- Hoess A.
- Debus J.
- Herfarth K.
Stereotactic single-dose radiotherapy (radiosurgery) of early stage nonsmall-cell lung cancer (NSCLC).
,
71- Wulf J.
- Haedinger U.
- Oppitz U.
- Thiele W.
- Mueller G.
- Flentje M.
Stereotactic radiotherapy for primary lung cancer and pulmonary metastases: a noninvasive treatment approach in medically inoperable patients.
,
72- Scorsetti M.
- Navarria P.
- Facoetti A.
- Lattuada P.
- Urso G.
- Mirandola A.
- et al.
Effectiveness of stereotactic body radiotherapy in the treatment of inoperable early-stage lung cancer.
,
73- Onishi H.
- Shirato H.
- Nagata Y.
- Hiraoka M.
- Fujino M.
- Gomi K.
- et al.
Hypofractionated stereotactic radiotherapy (HypoFXSRT) for stage I non-small cell lung cancer: updated results of 257 patients in a Japanese multi-institutional study.
,
74- Tsurugai Y.
- Kozuka T.
- Ishizuka N.
- Oguchi M.
Relationship between the consolidation to maximum tumor diameter ratio and outcomes following stereotactic body radiotherapy for stage I non-small-cell lung cancer.
,
75- Hayashi S.
- Tanaka H.
- Hoshi H.
Imaging characteristics of local recurrences after stereotactic body radiation therapy for stage I non-small cell lung cancer: evaluation of mass-like fibrosis.
,
76- Shibamoto Y.
- Hashizume C.
- Baba F.
- Ayakawa S.
- Miyakawa A.
- Murai T.
- et al.
Stereotactic body radiotherapy using a radiobiology-based regimen for stage I non-small-cell lung cancer.
,
77- Yamamoto T.
- Kadoya N.
- Shirata Y.
- Koto M.
- Sato K.
- Matsushita H.
- et al.
Impact of tumor attachment to the pleura measured by a pretreatment CT image on outcome of stage I NSCLC treated with stereotactic body radiotherapy.
,
78- Yoshitake T.
- Nakamura K.
- Shioyama Y.
- Sasaki T.
- Ohga S.
- Shinoto M.
- et al.
Stereotactic body radiation therapy for primary lung cancers clinically diagnosed without pathological confirmation: a single-institution experience.
,
79- Satoh Y.
- Onishi H.
- Nambu A.
- Araki T.
Volume-based parameters measured by using FDG PET/CT in patients with stage I NSCLC treated with stereotactic body radiation therapy: prognostic value.
,
80- Yamashita H.
- Haga A.
- Takahashi W.
- Takenaka R.
- Imae T.
- Takenaka S.
- et al.
Volumetric modulated arc therapy for lung stereotactic radiation therapy can achieve high local control rates.
,
81- Inoue T.
- Katoh N.
- Onimaru R.
- Shimizu S.
- Tsuchiya K.
- Suzuki R.
- et al.
Stereotactic body radiotherapy using gated radiotherapy with real-time tumor-tracking for stage I non-small cell lung cancer.
,
82- Matsuo Y.
- Shibuya K.
- Nagata Y.
- Takayama K.
- Norihisa Y.
- Mizowaki T.
- et al.
Prognostic factors in stereotactic body radiotherapy for non-small-cell lung cancer.
,
83- Hamamoto Y.
- Kataoka M.
- Yamashita M.
- Shinkai T.
- Kubo Y.
- Sugawara Y.
- et al.
Local control of metastatic lung tumors treated with SBRT of 48 Gy in four fractions: in comparison with primary lung cancer.
,
84- Shen Z.T.
- Wu X.H.
- Li B.
- Zhu X.X.
Clinical outcomes of cyberknife stereotactic body radiotherapy for peripheral stage I non-small cell lung cancer.
,
85- Wu D.
- Zhu H.
- Tang H.
- Li C.
- Xu F.
Clinical analysis of stereotactic body radiation therapy using extracranial gamma knife for patients with mainly bulky inoperable early stage non-small cell lung carcinoma.
,
86- Ng A.W.
- Tung S.Y.
- Wong V.Y.
Hypofractionated stereotactic radiotherapy for medically inoperable stage I non-small cell lung cancer-report on clinical outcome and dose to critical organs.
,
87- Xia T.
- Li H.
- Sun Q.
- Wang Y.
- Fan N.
- Yu Y.
- et al.
Promising clinical outcome of stereotactic body radiation therapy for patients with inoperable stage I/II non-small-cell lung cancer.
,
88- Kim M.J.
- Yeo S.G.
- Kim E.S.
- Min C.K.
- Se An P.
Intensity-modulated stereotactic body radiotherapy for stage I non-small cell lung cancer.
,
89- Song S.Y.
- Choi W.
- Shin S.S.
- Lee S.W.
- Ahn S.D.
- Kim J.H.
- et al.
Fractionated stereotactic body radiation therapy for medically inoperable stage I lung cancer adjacent to central large bronchus.
] photon SBRT studies were included in the survival outcome comparison analysis. Among them, treatment-related toxicities were reported in all the prospective studies [
12- Chang J.
- Senan S.
- Paul M.A.
- Mehran R.J.
- Louie A.V.
- Balter P.
- et al.
Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer: a pooled analysis of two randomised trials.
,
20- Timmerman R.
- Paulus R.
- Galvin J.
- Michalski J.
- Straube W.
- Bradley J.
- et al.
Stereotactic body radiation therapy for inoperable early stage lung cancer.
,
21- Timmerman R.D.
- Hu C.
- Michalski J.
- Straube W.
- Galvin J.
- Johnstone D.
- et al.
Long-term results of RTOG 0236: a phase II trial of stereotactic body radiation therapy (SBRT) in the treatment of patients with medically inoperable stage I non-small cell lung cancer.
,
22- Videtic G.M.
- Hu C.
- Singh A.K.
- Chang J.Y.
- Parker W.
- Olivier K.R.
- et al.
A randomized phase 2 study comparing 2 stereotactic body radiation therapy schedules for medically inoperable patients with stage I peripheral non-small cell lung cancer: NRG Oncology RTOG 0915 (NCCTG N0927).
,
23- Fakiris A.J.
- McGarry R.C.
- Yiannoutsos C.T.
- Papiez L.
- Williams M.
- Henderson M.A.
- et al.
Stereotactic body radiation therapy for early-stage non-small-cell lung carcinoma: four-year results of a prospective phase II study.
,
24- Baumann P.
- Nyman J.
- Hoyer M.
- Wennberg B.
- Gagliardi G.
- Lax I.
- et al.
Outcome in a prospective phase II trial of medically inoperable stage I non-small-cell lung cancer patients treated with stereotactic body radiotherapy.
,
25- Lindberg K.
- Nyman J.
- Källskog V.R.
- Hoyer M.
- Lund J.Ǻ.
- Lax I.
- et al.
Long-term results of a prospective phase II trial of medically inoperable stage I NSCLC treated with SBRT – the Nordic experience.
,
26- Navarro-Martin A.
- Aso S.
- Cacicedo J.
- Arnaiz M.
- Navarro V.
- Rosales S.
- et al.
Phase II trial of SBRT for stage I NSCLC: survival, local control, and lung function at 36 months.
,
27- Bral S.
- Gevaert T.
- Linthout N.
- Versmessen H.
- Collen C.
- Engels B.
- et al.
Prospective, risk-adapted strategy of stereotactic body radiotherapy for early-stage non-small-cell lung cancer: results of a phase II trial.
,
28- Ricardi U.
- Filippi A.R.
- Guarneri A.
- Giglioli F.R.
- Ciammella P.
- Franco P.
- et al.
Stereotactic body radiation therapy for early stage non-small cell lung cancer: results of a prospective trial.
,
29- Nagata Y.
- Hiraoka M.
- Shibata T.
- Onishi H.
- Kokubo M.
- Karasawa K.
- et al.
Prospective trial of stereotactic body radiation therapy for both operable and inoperable T1N0M0 non-small cell lung cancer: Japan Clinical Oncology Group Study JCOG0403.
,
30- Koto M.
- Takai Y.
- Ogawa Y.
- Matsushita H.
- Takeda K.
- Takahashi C.
- et al.
A phase II study on stereotactic body radiotherapy for stage I non-small cell lung cancer.
,
31- Onishi H.
- Kuriyama K.
- Komiyama T.
- Tanaka S.
- Sano N.
- Marino K.
- et al.
Clinical outcomes of stereotactic radiotherapy for stage I non-small cell lung cancer using a novel irradiation technique: patient self-controlled breath-hold and beam switching using a combination of linear accelerator and CT scanner.
,
32- Onimaru R.
- Shirato H.
- Shibata T.
- Hiraoka M.
- Ishikura S.
- Karasawa K.
- et al.
Phase I study of stereotactic body radiation therapy for peripheral T2N0M0 non-small cell lung cancer with PTV∗∗ 100 cc using a continual reassessment method (JCOG0702).
], and 40 retrospective studies [
34- Taremi M.
- Hope A.
- Dahele M.
- Pearson S.
- Fung S.
- Purdie T.
- et al.
Stereotactic body radiotherapy for medically inoperable lung cancer: prospective, single-center study of 108 consecutive patients.
,
37- Park H.S.
- Harder E.M.
- Mancini B.R.
- Decker R.H.
Central versus peripheral tumor location: influence on survival, local control, and toxicity following stereotactic body radiotherapy for primary non-small-cell lung cancer.
,
39- Parashar B.
- Port J.
- Arora S.
- Christos P.
- Trichter S.
- Nori D.
- et al.
Analysis of stereotactic body radiation vs. wedge resection vs. wedge resection plus cesium-131 brachytherapy in early stage lung cancer.
,
40- Kelley K.D.
- Benninghoff D.L.
- Stein J.S.
- Li J.Z.
- Byrnes R.T.
- Potters L.
- et al.
Medically inoperable peripheral lung cancer treated with stereotactic body radiation therapy.
,
42- Horne Z.D.
- Clump D.A.
- Vargo J.A.
- Shah S.
- Beriwal S.
- Burton S.A.
- et al.
Pretreatment SUVmax predicts progression-free survival in early-stage non-small cell lung cancer treated with stereotactic body radiation therapy.
,
44- Dunlap N.E.
- Larner J.M.
- Read P.W.
- Kozower B.D.
- Lau C.L.
- Sheng K.
- et al.
Size matters: a comparison of T1 and T2 peripheral non-small-cell lung cnacers treated with stereotactic body radiation therapy (SBRT).
,
45- Brown W.T.
- Wu X.
- Fayad F.
- Fowler J.F.
- García S.
- Monterroso M.I.
- et al.
Application of robotic stereotactic radiotherapy to peripheral stage I non-small cell lung cancer with curative intent.
,
46- Grills I.S.
- Hope A.J.
- Guckenberger M.
- Kestin L.L.
- Werner-Wasik M.
- Yan D.
- et al.
A collaborative analysis of stereotactic lung radiotherapy outcomes for early-stage non-small-cell lung cancer using daily online cone-beam computed tomography image-guided radiotherapy.
,
47- Videtic G.M.
- Stephans K.L.
- Woody N.M.
- Reddy C.A.
- Zhuang T.
- Magnelli A.
- et al.
30 Gy or 34 Gy? Comparing 2 single-fraction SBRT dose schedules for stage I medically inoperable non-small cell lung cancer.
,
49- Fischer-Valuck B.W.
- Boggs H.
- Katz S.
- Durci M.
- Acharya S.
- Rosen L.R.
Comparison of stereotactic body radiation therapy for biopsy-proven versus radiographically diagnosed early-stage non-small lung cancer: a single-institution experience.
,
52- Trakul N.
- Chang C.N.
- Harris J.
- Chapman C.
- Rao A.
- Shen J.
- et al.
Tumor volume-adpated dosing in stereotactic ablative radiotherapy of lung tumors.
,
53- Shaverdian N.
- Veruttipong D.
- Wang J.
- Schaue D.
- Kupelian P.
- Lee P.
Pretreatment immune parameters predict for overall survival and toxicity in early-stage non-small-cell lung cancer patients treated with stereotactic body radiation therapy.
,
54- Nath S.K.
- Sandhu A.P.
- Kim D.
- Bharne A.
- Nobiensky P.D.
- Lawson J.D.
- et al.
Locoregional and distant failure following image-guided stereotactic body radiation for early-stage primary lung cancer.
,
55- Olsen J.R.
- Robinson C.G.
- El Naqa I.
- Creach K.M.
- Drzymala R.E.
- Parikh P.J.
- et al.
Dose-response for stereotactic body radiotherapy in early-stage non-small-cell lung cancer.
,
56- Richardi U.
- Frezza G.
- Filippi A.R.
- Badellino S.
- Levis M.
- Navarria P.
- et al.
Stereotactic ablative radiotherapy for stage I histologically proven non-small cell lung cancer: an Italian multicenter observational study.
,
57- Jeppesen S.S.
- Schytte T.
- Jensen H.R.
- Brink C.
- Hansen O.
Stereotactic body radiation therapy versus conventional radiation therapy in patients with early stage non-small cell lung cancer: an updated retrospective study on local failure and survival rates.
,
58- Guckenberger M.
- Allgäuer M.
- Appold S.
- Dieckmann K.
- Ernst I.
- Ganswindt U.
- et al.
Safety and efficacy of stereotactic body radiotherapy for stage I non-small-cell lung cancer in routine clinical practice.
,
59- Andratschke N.
- Zimmermann F.
- Boehm E.
- Schill S.
- Schoenknecht C.
- Thamm R.
- et al.
Stereotactic radiotherapy of histologically proven inoperable stage I non-small cell lung cancer: patterns of failure.
,
60- Kopeck N.
- Paludan M.
- Petersen J.
- Hansen A.T.
- Grau C.
- Høyer M.
Co-morbidity index predicts for mortality after stereotactic body radiotherapy for medically inoperable early-stage non-small cell lung cancer.
,
61- Nyman J.
- Johansson K.A.
- Hultén U.
Stereotactic hypofractionated radiotherapy for stage I non-small cell lung cancer – mature results for medically inoperable patients.
,
65Van der Voort van Zyp NC, Prévost JB, Hoogeman MS, Praag J, van der Holt B, Levendag PC, et al. Stereotactic radiotherapy with real-time tumor tracking for non-small cell lung cancer: clinical outcome. 2009; 91: 296 - 300.
,
67- Janssen S.
- Kaesmann L.
- Rudat V.
- Rades D.
Stereotactic body radiotherapy (SBRT) with lower doses for selected patients with stage I non-small-cell lung cancer (NSCLC).
,
68- Duncker-Rohr V.
- Nestle U.
- Momm F.
- Prokic V.
- Heinemann F.
- Mix M.
- et al.
Stereotactic ablative radiotherapy for small lung tumors with a moderate dose. Favorable results and low toxicity.
,
69- Fritz P.
- Kraus H.J.
- Blaschke T.
- Mühlnickel W.
- Strauch K.
- Engel-Riedel W.
- et al.
Stereotactic, high single-dose irradiation of stage I non-small cell lung cancer (NSCLC) using four-dimensional CT scans for treatment planning.
,
70- Hof H.
- Muenter M.
- Oetzel D.
- Hoess A.
- Debus J.
- Herfarth K.
Stereotactic single-dose radiotherapy (radiosurgery) of early stage nonsmall-cell lung cancer (NSCLC).
,
71- Wulf J.
- Haedinger U.
- Oppitz U.
- Thiele W.
- Mueller G.
- Flentje M.
Stereotactic radiotherapy for primary lung cancer and pulmonary metastases: a noninvasive treatment approach in medically inoperable patients.
,
72- Scorsetti M.
- Navarria P.
- Facoetti A.
- Lattuada P.
- Urso G.
- Mirandola A.
- et al.
Effectiveness of stereotactic body radiotherapy in the treatment of inoperable early-stage lung cancer.
,
73- Onishi H.
- Shirato H.
- Nagata Y.
- Hiraoka M.
- Fujino M.
- Gomi K.
- et al.
Hypofractionated stereotactic radiotherapy (HypoFXSRT) for stage I non-small cell lung cancer: updated results of 257 patients in a Japanese multi-institutional study.
,
76- Shibamoto Y.
- Hashizume C.
- Baba F.
- Ayakawa S.
- Miyakawa A.
- Murai T.
- et al.
Stereotactic body radiotherapy using a radiobiology-based regimen for stage I non-small-cell lung cancer.
,
77- Yamamoto T.
- Kadoya N.
- Shirata Y.
- Koto M.
- Sato K.
- Matsushita H.
- et al.
Impact of tumor attachment to the pleura measured by a pretreatment CT image on outcome of stage I NSCLC treated with stereotactic body radiotherapy.
,
78- Yoshitake T.
- Nakamura K.
- Shioyama Y.
- Sasaki T.
- Ohga S.
- Shinoto M.
- et al.
Stereotactic body radiation therapy for primary lung cancers clinically diagnosed without pathological confirmation: a single-institution experience.
,
80- Yamashita H.
- Haga A.
- Takahashi W.
- Takenaka R.
- Imae T.
- Takenaka S.
- et al.
Volumetric modulated arc therapy for lung stereotactic radiation therapy can achieve high local control rates.
,
81- Inoue T.
- Katoh N.
- Onimaru R.
- Shimizu S.
- Tsuchiya K.
- Suzuki R.
- et al.
Stereotactic body radiotherapy using gated radiotherapy with real-time tumor-tracking for stage I non-small cell lung cancer.
,
82- Matsuo Y.
- Shibuya K.
- Nagata Y.
- Takayama K.
- Norihisa Y.
- Mizowaki T.
- et al.
Prognostic factors in stereotactic body radiotherapy for non-small-cell lung cancer.
,
84- Shen Z.T.
- Wu X.H.
- Li B.
- Zhu X.X.
Clinical outcomes of cyberknife stereotactic body radiotherapy for peripheral stage I non-small cell lung cancer.
,
85- Wu D.
- Zhu H.
- Tang H.
- Li C.
- Xu F.
Clinical analysis of stereotactic body radiation therapy using extracranial gamma knife for patients with mainly bulky inoperable early stage non-small cell lung carcinoma.
,
86- Ng A.W.
- Tung S.Y.
- Wong V.Y.
Hypofractionated stereotactic radiotherapy for medically inoperable stage I non-small cell lung cancer-report on clinical outcome and dose to critical organs.
,
87- Xia T.
- Li H.
- Sun Q.
- Wang Y.
- Fan N.
- Yu Y.
- et al.
Promising clinical outcome of stereotactic body radiation therapy for patients with inoperable stage I/II non-small-cell lung cancer.
,
88- Kim M.J.
- Yeo S.G.
- Kim E.S.
- Min C.K.
- Se An P.
Intensity-modulated stereotactic body radiotherapy for stage I non-small cell lung cancer.
,
89- Song S.Y.
- Choi W.
- Shin S.S.
- Lee S.W.
- Ahn S.D.
- Kim J.H.
- et al.
Fractionated stereotactic body radiation therapy for medically inoperable stage I lung cancer adjacent to central large bronchus.
]. These studies were included in the treatment-related toxicity comparison analysis. For 1 retrospective study without toxicity reporting, a similar retrospective study reporting on patients from the same institution treated in the same fashion and in similar time periods was used in the toxicity analysis [
51- Shultz D.B.
- Trakul N.
- Abelson J.A.
- Murphy J.D.
- Maxim P.G.
- Le Q.T.
- et al.
Imaging features associated with disease progression after stereotactic ablative radiotherapy for stage I non-small-cell lung cancer.
,
52- Trakul N.
- Chang C.N.
- Harris J.
- Chapman C.
- Rao A.
- Shen J.
- et al.
Tumor volume-adpated dosing in stereotactic ablative radiotherapy of lung tumors.
]. Patterns of failure were analyzed based on the information provided in 57 studies, which included 1 phase 3 (only the SBRT data was used), 10 phase 2, 0 phase 1, and 46 retrospective studies [
12- Chang J.
- Senan S.
- Paul M.A.
- Mehran R.J.
- Louie A.V.
- Balter P.
- et al.
Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer: a pooled analysis of two randomised trials.
,
20- Timmerman R.
- Paulus R.
- Galvin J.
- Michalski J.
- Straube W.
- Bradley J.
- et al.
Stereotactic body radiation therapy for inoperable early stage lung cancer.
,
21- Timmerman R.D.
- Hu C.
- Michalski J.
- Straube W.
- Galvin J.
- Johnstone D.
- et al.
Long-term results of RTOG 0236: a phase II trial of stereotactic body radiation therapy (SBRT) in the treatment of patients with medically inoperable stage I non-small cell lung cancer.
,
22- Videtic G.M.
- Hu C.
- Singh A.K.
- Chang J.Y.
- Parker W.
- Olivier K.R.
- et al.
A randomized phase 2 study comparing 2 stereotactic body radiation therapy schedules for medically inoperable patients with stage I peripheral non-small cell lung cancer: NRG Oncology RTOG 0915 (NCCTG N0927).
,
23- Fakiris A.J.
- McGarry R.C.
- Yiannoutsos C.T.
- Papiez L.
- Williams M.
- Henderson M.A.
- et al.
Stereotactic body radiation therapy for early-stage non-small-cell lung carcinoma: four-year results of a prospective phase II study.
,
24- Baumann P.
- Nyman J.
- Hoyer M.
- Wennberg B.
- Gagliardi G.
- Lax I.
- et al.
Outcome in a prospective phase II trial of medically inoperable stage I non-small-cell lung cancer patients treated with stereotactic body radiotherapy.
,
25- Lindberg K.
- Nyman J.
- Källskog V.R.
- Hoyer M.
- Lund J.Ǻ.
- Lax I.
- et al.
Long-term results of a prospective phase II trial of medically inoperable stage I NSCLC treated with SBRT – the Nordic experience.
,
26- Navarro-Martin A.
- Aso S.
- Cacicedo J.
- Arnaiz M.
- Navarro V.
- Rosales S.
- et al.
Phase II trial of SBRT for stage I NSCLC: survival, local control, and lung function at 36 months.
,
27- Bral S.
- Gevaert T.
- Linthout N.
- Versmessen H.
- Collen C.
- Engels B.
- et al.
Prospective, risk-adapted strategy of stereotactic body radiotherapy for early-stage non-small-cell lung cancer: results of a phase II trial.
,
28- Ricardi U.
- Filippi A.R.
- Guarneri A.
- Giglioli F.R.
- Ciammella P.
- Franco P.
- et al.
Stereotactic body radiation therapy for early stage non-small cell lung cancer: results of a prospective trial.
,
29- Nagata Y.
- Hiraoka M.
- Shibata T.
- Onishi H.
- Kokubo M.
- Karasawa K.
- et al.
Prospective trial of stereotactic body radiation therapy for both operable and inoperable T1N0M0 non-small cell lung cancer: Japan Clinical Oncology Group Study JCOG0403.
,
30- Koto M.
- Takai Y.
- Ogawa Y.
- Matsushita H.
- Takeda K.
- Takahashi C.
- et al.
A phase II study on stereotactic body radiotherapy for stage I non-small cell lung cancer.
,
31- Onishi H.
- Kuriyama K.
- Komiyama T.
- Tanaka S.
- Sano N.
- Marino K.
- et al.
Clinical outcomes of stereotactic radiotherapy for stage I non-small cell lung cancer using a novel irradiation technique: patient self-controlled breath-hold and beam switching using a combination of linear accelerator and CT scanner.
,
34- Taremi M.
- Hope A.
- Dahele M.
- Pearson S.
- Fung S.
- Purdie T.
- et al.
Stereotactic body radiotherapy for medically inoperable lung cancer: prospective, single-center study of 108 consecutive patients.
,
35- Mak R.H.
- Hermann G.
- Lewis J.H.
- Aerts H.J.W.L.
- Baldini E.H.
- Chen A.B.
- et al.
Outcomes by tumor histology and KRAS mutation status after lung stereotactic body radiation therapy for early-stage non-small-cell lung cancer.
,
36- Ebright M.I.
- Russo G.A.
- Gupta A.
- Subramaniam R.M.
- Fernando H.C.
- Kachnic L.A.
Positron emission tomography combined with diagnostic chest computed tomography enhances detection of regional recurrence after stereotactic body radiation therapy for early stage non-small cell lung cancer.
,
37- Park H.S.
- Harder E.M.
- Mancini B.R.
- Decker R.H.
Central versus peripheral tumor location: influence on survival, local control, and toxicity following stereotactic body radiotherapy for primary non-small-cell lung cancer.
,
38- Spratt D.E.
- Wu A.J.
- Adeseye V.
- Din S.U.
- Shaikh F.
- Woo K.M.
- et al.
Recurrence patterns and second primary lung cancers after stereotactic body radiation therapy for early-stage non-small-cell lung cancer: implications for surveillance.
,
39- Parashar B.
- Port J.
- Arora S.
- Christos P.
- Trichter S.
- Nori D.
- et al.
Analysis of stereotactic body radiation vs. wedge resection vs. wedge resection plus cesium-131 brachytherapy in early stage lung cancer.
,
40- Kelley K.D.
- Benninghoff D.L.
- Stein J.S.
- Li J.Z.
- Byrnes R.T.
- Potters L.
- et al.
Medically inoperable peripheral lung cancer treated with stereotactic body radiation therapy.
,
41- Vu C.C.
- Matthews R.
- Kim B.
- Franceschi D.
- Bilfinger T.V.
- Moore W.H.
Prognostic value of metabolic tumor volume and total lesion glycolysis from 18F-FDG PET/CT in patients undergoing stereotactic body radiation therapy for stage I non-small-cell lung cancer.
,
42- Horne Z.D.
- Clump D.A.
- Vargo J.A.
- Shah S.
- Beriwal S.
- Burton S.A.
- et al.
Pretreatment SUVmax predicts progression-free survival in early-stage non-small cell lung cancer treated with stereotactic body radiation therapy.
,
43- Vahdat S.
- Oermann E.K.
- Collins S.P.
- Yu X.
- Abedalthagafi M.
- DeBrito P.
- et al.
Cyberknife radiosurgery for inoperable stage IA non-small cell lung cancer: 18F-fluorodeoxyglucose positron emission tomography/computed tomography serial tumor response assessment.
,
44- Dunlap N.E.
- Larner J.M.
- Read P.W.
- Kozower B.D.
- Lau C.L.
- Sheng K.
- et al.
Size matters: a comparison of T1 and T2 peripheral non-small-cell lung cnacers treated with stereotactic body radiation therapy (SBRT).
,
45- Brown W.T.
- Wu X.
- Fayad F.
- Fowler J.F.
- García S.
- Monterroso M.I.
- et al.
Application of robotic stereotactic radiotherapy to peripheral stage I non-small cell lung cancer with curative intent.
,
46- Grills I.S.
- Hope A.J.
- Guckenberger M.
- Kestin L.L.
- Werner-Wasik M.
- Yan D.
- et al.
A collaborative analysis of stereotactic lung radiotherapy outcomes for early-stage non-small-cell lung cancer using daily online cone-beam computed tomography image-guided radiotherapy.
,
48- Burdick M.J.
- Stephans K.L.
- Reddy C.A.
- Djemil T.
- Srinivas S.M.
- Videtic G.M.
Maximum standardized uptake value from staging FDG-PET/CT does not predict treatment outcome for early-stage non-small-cell lung cancer treated with stereotactic body radiotherapy.
,
49- Fischer-Valuck B.W.
- Boggs H.
- Katz S.
- Durci M.
- Acharya S.
- Rosen L.R.
Comparison of stereotactic body radiation therapy for biopsy-proven versus radiographically diagnosed early-stage non-small lung cancer: a single-institution experience.
,
50- Zhang X.
- Liu H.
- Balter P.
- Allen P.K.
- Komaki R.
- Pan T.
- et al.
Positron emission tomography for assessing local failure after stereotactic body radiotherapy for non-small-cell lung cancer.
,
51- Shultz D.B.
- Trakul N.
- Abelson J.A.
- Murphy J.D.
- Maxim P.G.
- Le Q.T.
- et al.
Imaging features associated with disease progression after stereotactic ablative radiotherapy for stage I non-small-cell lung cancer.
,
54- Nath S.K.
- Sandhu A.P.
- Kim D.
- Bharne A.
- Nobiensky P.D.
- Lawson J.D.
- et al.
Locoregional and distant failure following image-guided stereotactic body radiation for early-stage primary lung cancer.
,
55- Olsen J.R.
- Robinson C.G.
- El Naqa I.
- Creach K.M.
- Drzymala R.E.
- Parikh P.J.
- et al.
Dose-response for stereotactic body radiotherapy in early-stage non-small-cell lung cancer.
,
56- Richardi U.
- Frezza G.
- Filippi A.R.
- Badellino S.
- Levis M.
- Navarria P.
- et al.
Stereotactic ablative radiotherapy for stage I histologically proven non-small cell lung cancer: an Italian multicenter observational study.
,
57- Jeppesen S.S.
- Schytte T.
- Jensen H.R.
- Brink C.
- Hansen O.
Stereotactic body radiation therapy versus conventional radiation therapy in patients with early stage non-small cell lung cancer: an updated retrospective study on local failure and survival rates.
,
59- Andratschke N.
- Zimmermann F.
- Boehm E.
- Schill S.
- Schoenknecht C.
- Thamm R.
- et al.
Stereotactic radiotherapy of histologically proven inoperable stage I non-small cell lung cancer: patterns of failure.
,
60- Kopeck N.
- Paludan M.
- Petersen J.
- Hansen A.T.
- Grau C.
- Høyer M.
Co-morbidity index predicts for mortality after stereotactic body radiotherapy for medically inoperable early-stage non-small cell lung cancer.
,
61- Nyman J.
- Johansson K.A.
- Hultén U.
Stereotactic hypofractionated radiotherapy for stage I non-small cell lung cancer – mature results for medically inoperable patients.
,
62- Kastelijn E.A.
- El Sharouni S.Y.
- Hofman F.N.
- Van Putte B.P.
- Monninkhof E.M.
- Van Vulpen M.
- et al.
Clinical outcomes in early-stage NSCLC treated with stereotactic body radiotherapy versus surgical resection.
,
63- Peulen H.
- Belderbos J.
- Rossi M.
- Sonke J.J.
Mid-ventilation based PTV margins in stereotactic body radiotherapy (SBRT): a clinical evaluation.
,
64- Senthi S.
- Lagerwaard F.J.
- Haasbeek C.J.A.
- Slotman B.J.
- Senan S.
Patterns of disease recurrence after stereotactic ablative radiotherapy for early stage non-small-cell lung cancer: a retrospective analysis.
,
65Van der Voort van Zyp NC, Prévost JB, Hoogeman MS, Praag J, van der Holt B, Levendag PC, et al. Stereotactic radiotherapy with real-time tumor tracking for non-small cell lung cancer: clinical outcome. 2009; 91: 296 - 300.
,
68- Duncker-Rohr V.
- Nestle U.
- Momm F.
- Prokic V.
- Heinemann F.
- Mix M.
- et al.
Stereotactic ablative radiotherapy for small lung tumors with a moderate dose. Favorable results and low toxicity.
,
69- Fritz P.
- Kraus H.J.
- Blaschke T.
- Mühlnickel W.
- Strauch K.
- Engel-Riedel W.
- et al.
Stereotactic, high single-dose irradiation of stage I non-small cell lung cancer (NSCLC) using four-dimensional CT scans for treatment planning.
,
70- Hof H.
- Muenter M.
- Oetzel D.
- Hoess A.
- Debus J.
- Herfarth K.
Stereotactic single-dose radiotherapy (radiosurgery) of early stage nonsmall-cell lung cancer (NSCLC).
,
71- Wulf J.
- Haedinger U.
- Oppitz U.
- Thiele W.
- Mueller G.
- Flentje M.
Stereotactic radiotherapy for primary lung cancer and pulmonary metastases: a noninvasive treatment approach in medically inoperable patients.
,
73- Onishi H.
- Shirato H.
- Nagata Y.
- Hiraoka M.
- Fujino M.
- Gomi K.
- et al.
Hypofractionated stereotactic radiotherapy (HypoFXSRT) for stage I non-small cell lung cancer: updated results of 257 patients in a Japanese multi-institutional study.
,
74- Tsurugai Y.
- Kozuka T.
- Ishizuka N.
- Oguchi M.
Relationship between the consolidation to maximum tumor diameter ratio and outcomes following stereotactic body radiotherapy for stage I non-small-cell lung cancer.
,
75- Hayashi S.
- Tanaka H.
- Hoshi H.
Imaging characteristics of local recurrences after stereotactic body radiation therapy for stage I non-small cell lung cancer: evaluation of mass-like fibrosis.
,
77- Yamamoto T.
- Kadoya N.
- Shirata Y.
- Koto M.
- Sato K.
- Matsushita H.
- et al.
Impact of tumor attachment to the pleura measured by a pretreatment CT image on outcome of stage I NSCLC treated with stereotactic body radiotherapy.
,
78- Yoshitake T.
- Nakamura K.
- Shioyama Y.
- Sasaki T.
- Ohga S.
- Shinoto M.
- et al.
Stereotactic body radiation therapy for primary lung cancers clinically diagnosed without pathological confirmation: a single-institution experience.
,
79- Satoh Y.
- Onishi H.
- Nambu A.
- Araki T.
Volume-based parameters measured by using FDG PET/CT in patients with stage I NSCLC treated with stereotactic body radiation therapy: prognostic value.
,
82- Matsuo Y.
- Shibuya K.
- Nagata Y.
- Takayama K.
- Norihisa Y.
- Mizowaki T.
- et al.
Prognostic factors in stereotactic body radiotherapy for non-small-cell lung cancer.
,
84- Shen Z.T.
- Wu X.H.
- Li B.
- Zhu X.X.
Clinical outcomes of cyberknife stereotactic body radiotherapy for peripheral stage I non-small cell lung cancer.
,
85- Wu D.
- Zhu H.
- Tang H.
- Li C.
- Xu F.
Clinical analysis of stereotactic body radiation therapy using extracranial gamma knife for patients with mainly bulky inoperable early stage non-small cell lung carcinoma.
,
86- Ng A.W.
- Tung S.Y.
- Wong V.Y.
Hypofractionated stereotactic radiotherapy for medically inoperable stage I non-small cell lung cancer-report on clinical outcome and dose to critical organs.
,
87- Xia T.
- Li H.
- Sun Q.
- Wang Y.
- Fan N.
- Yu Y.
- et al.
Promising clinical outcome of stereotactic body radiation therapy for patients with inoperable stage I/II non-small-cell lung cancer.
,
88- Kim M.J.
- Yeo S.G.
- Kim E.S.
- Min C.K.
- Se An P.
Intensity-modulated stereotactic body radiotherapy for stage I non-small cell lung cancer.
,
89- Song S.Y.
- Choi W.
- Shin S.S.
- Lee S.W.
- Ahn S.D.
- Kim J.H.
- et al.
Fractionated stereotactic body radiation therapy for medically inoperable stage I lung cancer adjacent to central large bronchus.
,
90- Baba F.
- Shibamoto Y.
- Ogino H.
- Murata R.
- Sugie C.
- Iwata H.
- et al.
Clinical outcomes of stereotactic body radiotherapy for stage I non-small cell lung cancer using different doses depending on tumor size.
]. Among them, 1 retrospective study was not included in the survival outcome or toxicity profile analysis [
[90]- Baba F.
- Shibamoto Y.
- Ogino H.
- Murata R.
- Sugie C.
- Iwata H.
- et al.
Clinical outcomes of stereotactic body radiotherapy for stage I non-small cell lung cancer using different doses depending on tumor size.
]. It was included in the patterns of failure analysis because of a lack of information in a study from the same institution that was used for survival outcome analysis. At last, 8 studies providing adequate clinical information were included in the clinical outcome comparison for T1 vs. T2 NSCLC analysis [
10- Onishi H.
- Shirato H.
- Nagata Y.
- Hiraoka M.
- Fujino M.
- Gomi K.
- et al.
Stereotactic body radiotherapy (SBRT) for operable stage I non-small-cell lung cancer: can SBRT be comparable to surgery?.
,
24- Baumann P.
- Nyman J.
- Hoyer M.
- Wennberg B.
- Gagliardi G.
- Lax I.
- et al.
Outcome in a prospective phase II trial of medically inoperable stage I non-small-cell lung cancer patients treated with stereotactic body radiotherapy.
,
30- Koto M.
- Takai Y.
- Ogawa Y.
- Matsushita H.
- Takeda K.
- Takahashi C.
- et al.
A phase II study on stereotactic body radiotherapy for stage I non-small cell lung cancer.
,
45- Brown W.T.
- Wu X.
- Fayad F.
- Fowler J.F.
- García S.
- Monterroso M.I.
- et al.
Application of robotic stereotactic radiotherapy to peripheral stage I non-small cell lung cancer with curative intent.
,
58- Guckenberger M.
- Allgäuer M.
- Appold S.
- Dieckmann K.
- Ernst I.
- Ganswindt U.
- et al.
Safety and efficacy of stereotactic body radiotherapy for stage I non-small-cell lung cancer in routine clinical practice.
,
59- Andratschke N.
- Zimmermann F.
- Boehm E.
- Schill S.
- Schoenknecht C.
- Thamm R.
- et al.
Stereotactic radiotherapy of histologically proven inoperable stage I non-small cell lung cancer: patterns of failure.
,
87- Xia T.
- Li H.
- Sun Q.
- Wang Y.
- Fan N.
- Yu Y.
- et al.
Promising clinical outcome of stereotactic body radiation therapy for patients with inoperable stage I/II non-small-cell lung cancer.
,
90- Baba F.
- Shibamoto Y.
- Ogino H.
- Murata R.
- Sugie C.
- Iwata H.
- et al.
Clinical outcomes of stereotactic body radiotherapy for stage I non-small cell lung cancer using different doses depending on tumor size.
]. Among them, 1 retrospective study was not included in previous analyses as a study of larger sample size was included instead [
10- Onishi H.
- Shirato H.
- Nagata Y.
- Hiraoka M.
- Fujino M.
- Gomi K.
- et al.
Stereotactic body radiotherapy (SBRT) for operable stage I non-small-cell lung cancer: can SBRT be comparable to surgery?.
,
73- Onishi H.
- Shirato H.
- Nagata Y.
- Hiraoka M.
- Fujino M.
- Gomi K.
- et al.
Hypofractionated stereotactic radiotherapy (HypoFXSRT) for stage I non-small cell lung cancer: updated results of 257 patients in a Japanese multi-institutional study.
]. PBT studies included 4 prospective studies (1 phase 2, and 3 phase I/II), and 5 retrospective studies [
91- Bush D.A.
- Cheek G.
- Zaheer S.
- Wallen J.
- Mirshahidi H.
- Katerelos A.
- et al.
High-dose hypofractionated proton beam radiation therapy is safe and effective for central and peripheral early-stage non-small cell lung cancer: results of a 12-year experience at Loma Linda University Medical Center.
,
92- Miyamoto T.
- Baba M.
- Sugane T.
- Nakajima M.
- Yashiro T.
- Kagei K.
- et al.
Carbon ion radiotherapy for stage I non-small cell lung cancer using a regimen of four fractions during 1 week.
,
93- Miyamoto T.
- Baba M.
- Yamamoto N.
- Koto M.
- Sugawara T.
- Yashiro T.
- et al.
Curative treatment of stage I non-small-cell lung cancer with carbon ion beams using a hypofractionated regimen.
,
94- Karube M.
- Yamamoto N.
- Nakajima M.
- Yamashita H.
- Nakagawa K.
- Miyamoto T.
- et al.
Single-fraction carbon-ion radiation therapy for patients 80 years of age and older with stage I non-small cell lung cancer.
,
95- Westover K.D.
- Seco J.
- Adams J.A.
- Lanuti M.
- Choi N.C.
- Engelsman M.
- et al.
Proton SBRT for medically inoperable stage I NSCLC.
,
96- Hatayama Y.
- Nakamura T.
- Suzuki M.
- Azami Y.
- Ono T.
- Yabuuchi T.
- et al.
Clinical outcomes and prognostic factors of high-dose proton beam therapy for peripheral stage I non-small-cell lung cancer.
,
97- Kanemoto A.
- Okumura T.
- Ishikawa H.
- Mizumoto M.
- Oshiro Y.
- Kurishima K.
- et al.
Outcomes and prognostic factors for recurrence after high-dose proton beam therapy for centrally and peripherally located stage I non-small-cell lung cancer.
,
98- Fujii O.
- Demizu Y.
- Hashimoto N.
- Takagi M.
- Terashima K.
- Mima M.
- et al.
Particle therapy for clinically diagnosed stage I lung cancer: comparison with pathologically proven non-small cell lung cancer.
,
99- Fujii O.
- Demizu Y.
- Hashimoto N.
- Araya M.
- Takagi M.
- Terashima K.
- et al.
A retrospective comparison of proton therapy and carbon ion therapy for stage I non-small cell lung cancer.
]. All were included in the survival outcome and toxicity profile comparison analyses [
91- Bush D.A.
- Cheek G.
- Zaheer S.
- Wallen J.
- Mirshahidi H.
- Katerelos A.
- et al.
High-dose hypofractionated proton beam radiation therapy is safe and effective for central and peripheral early-stage non-small cell lung cancer: results of a 12-year experience at Loma Linda University Medical Center.
,
92- Miyamoto T.
- Baba M.
- Sugane T.
- Nakajima M.
- Yashiro T.
- Kagei K.
- et al.
Carbon ion radiotherapy for stage I non-small cell lung cancer using a regimen of four fractions during 1 week.
,
93- Miyamoto T.
- Baba M.
- Yamamoto N.
- Koto M.
- Sugawara T.
- Yashiro T.
- et al.
Curative treatment of stage I non-small-cell lung cancer with carbon ion beams using a hypofractionated regimen.
,
94- Karube M.
- Yamamoto N.
- Nakajima M.
- Yamashita H.
- Nakagawa K.
- Miyamoto T.
- et al.
Single-fraction carbon-ion radiation therapy for patients 80 years of age and older with stage I non-small cell lung cancer.
,
95- Westover K.D.
- Seco J.
- Adams J.A.
- Lanuti M.
- Choi N.C.
- Engelsman M.
- et al.
Proton SBRT for medically inoperable stage I NSCLC.
,
96- Hatayama Y.
- Nakamura T.
- Suzuki M.
- Azami Y.
- Ono T.
- Yabuuchi T.
- et al.
Clinical outcomes and prognostic factors of high-dose proton beam therapy for peripheral stage I non-small-cell lung cancer.
,
97- Kanemoto A.
- Okumura T.
- Ishikawa H.
- Mizumoto M.
- Oshiro Y.
- Kurishima K.
- et al.
Outcomes and prognostic factors for recurrence after high-dose proton beam therapy for centrally and peripherally located stage I non-small-cell lung cancer.
,
98- Fujii O.
- Demizu Y.
- Hashimoto N.
- Takagi M.
- Terashima K.
- Mima M.
- et al.
Particle therapy for clinically diagnosed stage I lung cancer: comparison with pathologically proven non-small cell lung cancer.
,
99- Fujii O.
- Demizu Y.
- Hashimoto N.
- Araya M.
- Takagi M.
- Terashima K.
- et al.
A retrospective comparison of proton therapy and carbon ion therapy for stage I non-small cell lung cancer.
]. For patterns of failure analysis, 8 studies were included [
92- Miyamoto T.
- Baba M.
- Sugane T.
- Nakajima M.
- Yashiro T.
- Kagei K.
- et al.
Carbon ion radiotherapy for stage I non-small cell lung cancer using a regimen of four fractions during 1 week.