Abstract
Purpose
Safetac-based soft silicone dressings used in a management setting decrease the severity
of radiation-induced acute skin reactions but do not affect moist desquamation rates.
Here we investigate the prophylactic use of another Safetac product, Mepitel Film,
on moist desquamation rates.
Material and methods
A total of 80 breast cancer patients receiving radiation therapy were recruited between
October 2012 and April 2013; 78 participants contributed data for analysis. Lateral
and medial halves of the skin areas to be irradiated were randomised to Mepitel Film
or aqueous cream; skin dose was measured using thermoluminescent dosimeters; skin
reaction severity was assessed using RISRAS and RTOG scales.
Results
Overall skin reaction severity was reduced by 92% (p < 0.0001) in favour of Mepitel Film (RISRAS). All patients developed some form of reaction
in cream-treated skin which progressed to moist desquamation in 26% of patients (RTOG
grades I: 28%; IIA: 46%; IIB: 18%; III: 8%). Only 44% of patients had a skin reaction
under the Film, which did not progress to moist desquamation in any of the patients
(RTOG grades I: 36%; IIA: 8%).
Conclusions
Mepitel Film completely prevented moist desquamation and reduced skin reaction severity
by 92% when used prophylactically in our cohort.
Keywords
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Article info
Publication history
Published online: January 31, 2014
Accepted:
January 12,
2014
Received in revised form:
January 4,
2014
Received:
August 21,
2013
Identification
Copyright
© 2014 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
