Safetac-based soft silicone dressings used in a management setting decrease the severity of radiation-induced acute skin reactions but do not affect moist desquamation rates. Here we investigate the prophylactic use of another Safetac product, Mepitel Film, on moist desquamation rates.
Material and methods
A total of 80 breast cancer patients receiving radiation therapy were recruited between October 2012 and April 2013; 78 participants contributed data for analysis. Lateral and medial halves of the skin areas to be irradiated were randomised to Mepitel Film or aqueous cream; skin dose was measured using thermoluminescent dosimeters; skin reaction severity was assessed using RISRAS and RTOG scales.
Overall skin reaction severity was reduced by 92% (p < 0.0001) in favour of Mepitel Film (RISRAS). All patients developed some form of reaction in cream-treated skin which progressed to moist desquamation in 26% of patients (RTOG grades I: 28%; IIA: 46%; IIB: 18%; III: 8%). Only 44% of patients had a skin reaction under the Film, which did not progress to moist desquamation in any of the patients (RTOG grades I: 36%; IIA: 8%).
Mepitel Film completely prevented moist desquamation and reduced skin reaction severity by 92% when used prophylactically in our cohort.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Radiotherapy and Oncology
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- The prevention and management of acute skin reactions related to radiation therapy: a systematic review and practice guideline.Support Care Cancer. 2006; 14: 802-817
- Prophylaxis and management of acute radiation-induced skin reactions: a systematic review of the literature.Curr Oncol. 2010; 17: 94-112
- Mometasone furoate effect on acute skin toxicity in breast cancer patients receiving radiotherapy: a phase III double-blind, randomized trial from the North Central Cancer Treatment Group N06C4.Int J Radiat Oncol Biol Phys. 2011; 79: 1460-1466
- Prophylaxis with a cream containing urea reduces the incidence and severity of radio-induced dermatitis.Clin Transl Oncol. 2010; 12: 43-48
- Topical hyaluronic acid vs. standard of care for the prevention of radiation dermatitis after adjuvant radiotherapy for breast cancer: single-blind randomized phase III clinical trial.Int J Radiat Oncol Biol Phys. 2012; 83: 1089-1094
- Assessing the effectiveness of Dead Sea products as prophylactic agents for acute radiochemotherapy-induced skin and mucosal toxicity in patients with head and neck cancers: a phase 2 study.Isr Med Assoc J. 2007; 9: 439-442
- Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer.J Clin Oncol. 2004; 22: 1447-1453
- Phase III trial of an emulsion containing trolamine for the prevention of radiation dermatitis in patients with advanced squamous cell carcinoma of the head and neck: results of Radiation Therapy Oncology Group Trial 99–13.J Clin Oncol. 2006; 24: 2092-2097
- A prospective randomized, placebo-controlled skin care study in women diagnosed with breast cancer undergoing radiation therapy.Oncol Nurs Forum. 2010; 37: 619-626
- Trolamine emulsion for the prevention of radiation dermatitis in patients with squamous cell carcinoma of the head and neck.Support Care Cancer. 2012; 20: 185-190
- Aloe vera for preventing radiation-induced skin reactions; a systematic literature review.Clin Oncol. 2005; 17: 478-484
- Does aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trial.Radiother Oncol. 2004; 73: 153-162
- No differences between Calendula cream and aqueous cream in the prevention of acute radiation skin reactions – results from a randomised blinded trial.Eur J Oncol Nurs. 2013; 17: 429-435
- Randomized, paired comparison of No-Sting Barrier Film versus sorbolene cream (10% glycerine) skin care during postmastectomy irradiation.Int J Radiat Oncol Biol Phys. 2004; 58: 241-246
- A paired, double-blind, randomized comparison of a moisturizing durable barrier cream to 10% glycerine cream in the prophylactic management of postmastectomy irradiation skin care: trans Tasman Radiation Oncology Group (TROG) 04.01.Int J Radiat Oncol Biol Phys. 2013; 86: 45-50
- Mepilex Lite dressings for the management of radiation-induced erythema: a systematic inpatient controlled clinical trial.Br J Radiol. 2010; 83: 971-978
- Randomized intra-patient controlled trial of Mepilex Lite dressings versus aqueous cream in managing radiation-induced skin reactions postmastectomy.J Cancer Sci Ther. 2012; 04: 347-356
- Radiation-induced skin reactions 3: evaluating the RISRAS.Br J Nurs. 1999; 8: 1305-1312
- A case study to evaluate a new soft silicone dressing, Mepilex Lite, for patients with radiation skin reactions.Cancer Nurs. 2008; 31: E8-E14
- Toxicity criteria of the Radiation Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer.Int J Radiat Oncol Biol Phys. 1995; 31: 1341-1346
- Acute radiation dermatitis and pneumonitis in Japanese breast cancer patients with whole breast hypofractionated radiotherapy compared to conventional radiotherapy.Jpn J Clin Oncol. 2008; 38: 334-338
- Personal characteristics, therapy modalities and individual DNA repair capacity as predictive factors of acute skin toxicity in an unselected cohort of breast cancer patients receiving radiotherapy.Radiother Oncol. 2003; 69: 145-153
- Prognostic factors for acute and late skin reactions in radiotherapy patients.Int J Radiat Oncol Biol Phys. 1996; 36: 1065-1075
- Factors influencing the severity of radiation skin and oral mucosal reactions: development of a conceptual framework.Eur J Cancer Care. 2002; 11: 33-43
- Post-treatment skin reactions reported by cancer patients differ by race, not by treatment or expectations.Br J Cancer. 2007; 97: 14-21
Published online: January 31, 2014
Accepted: January 12, 2014
Received in revised form: January 4, 2014
Received: August 21, 2013
© 2014 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.