Abstract
Purpose
The Gastro-Intestinal Working Party of the EORTC Radiation Oncology Group (GIWP-ROG)
developed guidelines for target volume definition in neoadjuvant radiation of adenocarcinomas
of the gastroesophageal junction (GEJ) and the stomach.
Methods and materials
Guidelines about the definition of the clinical target volume (CTV) are based on a
systematic literature review of the location and frequency of local recurrences and
lymph node involvement in adenocarcinomas of the GEJ and the stomach. Therefore, MEDLINE
was searched up to August 2008.
Guidelines concerning prescription, planning and treatment delivery are based on a
consensus between the members of the GIWP-ROG.
Results
In order to support a curative resection of GEJ and gastric cancer, an individualized
preoperative treatment volume based on tumour location has to include the primary
tumour and the draining regional lymph nodes area. Therefore we recommend to use the
2nd English Edition of the Japanese Classification of Gastric Carcinoma of the Japanese
Gastric Cancer Association which developed the concept of assigning tumours of the
GEJ and the stomach to anatomically defined sub-sites corresponding respectively to
a distinct lymphatic spread pattern.
Conclusion
The GIWP-ROG defined guidelines for preoperative irradiation of adenocarcinomas of
the GEJ and the stomach to reduce variability in the framework of future clinical
trials.
Keywords
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Article info
Publication history
Published online: April 17, 2009
Accepted:
March 5,
2009
Received:
January 12,
2009
Identification
Copyright
© 2009 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
