Abstract
Background and purpose
There are only a limited number of reports of treatment of prostate cancer with permanent
prostate seed I125 brachytherapy (PPB) in Europe. We describe results from one Finnish institution having
treated 444 patients with a follow-up of eight years.
Material and methods
Morbidity was evaluated by International Prostate Symptom Score and International
Index of Erectile Function questionnaires. Urine flow, residual urine volume and the
PSA values were measured pre-treatment and during follow-up. Any additional treatments
were recorded.
Results
PPB was well tolerated. Median IPSS increased from 8 at baseline to 18 at three months
post-therapy and returned to baseline score within 12 months. Median urine flow decreased
from 15.2 ml/s at baseline to 10.2 ml/s at three months and returned to baseline value within two years. Acute urinary
retention, potency preservation and severe proctitis were observed in 11%, 86% and
2% of patients, respectively. The PSA bounce was observed in 13% and PSA nadir ⩽0.5 μg/l was reached by 81% of patients. Disease-free survival (DFS) was 90.2%. In the
Cox regression analysis, the independent predictors of DFS were risk group and PSA
nadir ⩽0.5 μg/l (p < 0.0001 for both). PC-specific survival was 98.5% and overall survival was 94.6%.
Conclusions
Our results are in concordance and comparable with other reports on PPB.
Keywords
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Article info
Publication history
Published online: January 23, 2009
Accepted:
December 9,
2008
Received in revised form:
November 24,
2008
Received:
February 5,
2008
Identification
Copyright
© 2009 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
