Prostate cancer brachytherapy| Volume 91, ISSUE 2, P213-216, May 2009

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Eight years experience of local prostate cancer treatment with permanent I125 seed brachytherapy – Morbidity and outcome results

Published:January 23, 2009DOI:


      Background and purpose

      There are only a limited number of reports of treatment of prostate cancer with permanent prostate seed I125 brachytherapy (PPB) in Europe. We describe results from one Finnish institution having treated 444 patients with a follow-up of eight years.

      Material and methods

      Morbidity was evaluated by International Prostate Symptom Score and International Index of Erectile Function questionnaires. Urine flow, residual urine volume and the PSA values were measured pre-treatment and during follow-up. Any additional treatments were recorded.


      PPB was well tolerated. Median IPSS increased from 8 at baseline to 18 at three months post-therapy and returned to baseline score within 12 months. Median urine flow decreased from 15.2 ml/s at baseline to 10.2 ml/s at three months and returned to baseline value within two years. Acute urinary retention, potency preservation and severe proctitis were observed in 11%, 86% and 2% of patients, respectively. The PSA bounce was observed in 13% and PSA nadir ⩽0.5 μg/l was reached by 81% of patients. Disease-free survival (DFS) was 90.2%. In the Cox regression analysis, the independent predictors of DFS were risk group and PSA nadir ⩽0.5 μg/l (p < 0.0001 for both). PC-specific survival was 98.5% and overall survival was 94.6%.


      Our results are in concordance and comparable with other reports on PPB.


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