Abstract
Purpose
The aim of this population-based study was to examine the impact of postmastectomy
radiotherapy on the risk of local recurrence in patients with invasive lobular breast
cancer (ILC).
Methods
The population-based Eindhoven Cancer Registry was used to select all patients with
ILC, who underwent mastectomy in five general hospitals in the southern part of the
Netherlands between 1995 and 2002. Of the 499 patients 383 patients fulfilled the
eligibility criteria. Of these patients, 170 (44.4%) had received postmastectomy radiotherapy.
The median follow-up was 7.2 years. Fourteen patients (3.7%) were lost to follow-up.
Results
During follow-up 22 patients developed a local recurrence, of whom 4 had received
postmastectomy radiotherapy. The 5-year actuarial risk of local recurrence was 2.1%
for the patients with and 8.7% for the patients without postmastectomy radiotherapy.
After adjustment for age at diagnosis, tumour stage and adjuvant systemic treatment,
the patients who underwent postmastectomy radiotherapy were found to have a more than
3 times lower risk of local recurrence compared to the patients without (Hazard Ratio
0.30; 95% Confidence Interval: 0.10–0.89).
Conclusion
Local control is excellent for patients with ILC who undergo postmastectomy radiotherapy
and significantly better than for patients not receiving radiotherapy.
Keywords
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Article info
Publication history
Published online: October 24, 2008
Accepted:
September 23,
2008
Received in revised form:
September 10,
2008
Received:
April 28,
2008
Identification
Copyright
© 2008 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
