Abstract
Background and purpose: Intraoperative radiotherapy (IORT) has been considered for treatment of pancreas
cancer since local recurrence rates are very high. This study assesses the efficacy
and safety of IORT in pancreatic cancer. Materials and methods: We conducted a systematic review of scientific literature from January 1995 to February
2007, including Medline, Embase, ISI Web of Science and HTA (Health Technology Assessment).
By applying a series of inclusion criteria, two independent reviewers selected those
studies in which a minimum of 30 patients received IORT and which furnished survival
results based on a minimum 3-month follow-up. Results: Fourteen papers were included, one was an IORT assessment report, 5 were cohort studies,
and the remaining 8 were case series studies, 2 of which belonged to the same series.
In general, these studies showed that IORT could slightly increase survival among
patients with pancreatic cancer in localized stages. However, the results were not
conclusively in favor of IORT in the case of pancreatic cancer in locally advanced
and metastatic stages. There were no published studies that assessed quality of life.
Conclusions: There is no clear evidence to indicate that IORT is more effective than other therapies
in treating pancreatic cancer in locally advanced and metastatic stages.
Keywords
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Article info
Publication history
Published online: January 16, 2008
Accepted:
December 7,
2007
Received in revised form:
December 3,
2007
Received:
September 14,
2007
Identification
Copyright
© 2007 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
