Abstract
Purpose
Radiotherapy is, similar to surgery, a local treatment. In the case of breast cancer,
it is generally given after conservative or after more extensive, tumour and patient
adapted, surgery. The target volumes can be the breast and/or the thoracic wall and/or
the regional lymph node areas. The integration and the extent of radiotherapy as part
of the comprehensive treatment of the breast cancer patient, including the amount
of surgery and the sequencing with the systemic treatments, has to be well discussed
with all medical specialists involved in treating breast cancer on a multidisciplinary
basis. Guidelines for the appropriate prescription and execution of radiotherapy are
of utmost importance. However, individualisation based on the individual patients’
and tumours’ characteristics should always be envisaged.
Materials and methods
Based on a review of the literature the level of evidence that is available for the
indications for radiotherapy is summarised, as well as the main clinical questions
that are unanswered today. An overview of the recent and ongoing clinical trails in
breast cancer will highlight some of the current ongoing debates.
Conclusions
In the case of breast cancer, radiotherapy, given after as well conservative as extensive
risk-adapted surgery, significantly reduces the risk of local and regional recurrences.
Especially for patients with an intermediate to high absolute risk for local recurrences,
a positive influence on overall survival has been shown, notably when appropriate
radiotherapy techniques are used. Most important is that the best results that we
can offer to our breast cancer patients for all clinical endpoints (local and regional
control; quality of life; cosmetic results; survival) can be obtained by a multidisciplinary
and patient-oriented approach, involving all those involved in the treatment of breast
cancer patients.
Keywords
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Article info
Publication history
Published online: June 30, 2007
Accepted:
June 2,
2007
Received in revised form:
May 30,
2007
Received:
January 25,
2007
Identification
Copyright
© 2007 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
