Abstract
Background and purpose: Permanent seed implantation was used in the management of primary and recurrent
prostate cancer in patients who had been treated previously by radiotherapy of the
true pelvis.
Material and methods: Between 1993 and 1998 a total of 21 patients received an I-125 implant after radiotherapy
for bladder cancer (two patients), anal cancer (one patient), seminoma (two patients)
and prostate cancer (16 patients). Two seminoma and 10 prostate cancer patients were
treated after earlier definitive external beam radiation therapy (EBRT), while the
bladder and anal cancer were initially treated with EBRT plus iridium implantation.
Six prostate cancer patients were initially treated by brachytherapy alone. The interval
between the two treatments was longer in patients with radiotherapy for other malignancies
than prostate cancer.
Results: After EBRT no serious late toxicity was observed. However, 1/6 patients who had
two seed implants experienced serious complications, resulting in a vesico-rectal
fistula.
Conclusions: The permanent seed implantation with I-125 is feasible after previous radiotherapy
in the prostate area. Also a second implant is possible, but may result in severe
complications, depending on the initial dose and interval between the two treatments.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Radiotherapy and OncologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Iodine-125 seed implantation for localized prostate cancer.J Brachyther Int. 1998; 14: 2-27
- Preliminary results with Iodine-125 seeds for permanent implantation in patients with localized prostatic cancer.Radiother Oncol. 1987; 10: 91-95
- Permanent brachytherapy for localized prostate cancer, from hand to strand.Radiother Oncol. 1998; : 20
- The effect of local control on metastatic dissemination in carcinoma of the prostate: long-term results in patients treated with 125 Iodine implantation.Int J Radiat Oncol Biol Phys. 1991; 21: 537-547
- 125 Iodine prostate implants for recurrent carcinomas after external beam irradiation: preliminary results.Cancer. 1980; 45: 2717-2724
- The importance of local control in the treatment of prostatic cancer.J Urol. 1992; 147: 917-921
- Use of percutaneous transperineal Au-198 seeds to treat recurrent prostate adenocarcinoma after failure of definitive radiotherapy.Prostate. 1993; 23: 283-290
- Management of relapsing disease in prostate cancer.Cancer. 1992; 70: 329-334
- Radical prostatectomy after radiation therapy for cancer of prostate, feasibility and prognosis.J Urol. 1988; 140: 1455-1459
- Local failure and related complications after definitive treatment of carcinoma of the prostate by irradiation or surgery.Semin Urol. 1990; 8: 232-246
- Treatment of clinical local failure after radiation therapy for prostate cancer.J Urol. 1993; 150: 1851-1855
- Permanent gold-198 implant for locally recurrent adenocarcinoma of the prostate after failing initial radiotherapy.J Brachyther Int. 1998; 14: 233
Article info
Publication history
Accepted:
July 20,
2000
Received:
February 10,
2000
Identification
Copyright
© 2000 Elsevier Science Ireland Ltd. Published by Elsevier Inc. All rights reserved.
