Radiotherapy & Oncology
Volume 96, Issue 3 , Pages 311-316 , September 2010

Detection and compensation of organ/lesion motion using 4D-PET/CT respiratory gated acquisition techniques

  • Valentino Bettinardi

      Affiliations

    • Nuclear Medicine, San Raffaele Scientific Institute, Milan, Italy
    • Institute for Bioimaging and Molecular Physiology, National Research Council, Milan, Italy
    • Corresponding Author InformationCorresponding author. Address: Nuclear Medicine, San Raffaele Scientific Institute, Milan, Italy.
  • ,
  • Maria Picchio

      Affiliations

    • Nuclear Medicine, San Raffaele Scientific Institute, Milan, Italy
    • Institute for Bioimaging and Molecular Physiology, National Research Council, Milan, Italy
  • ,
  • Nadia Di Muzio

      Affiliations

    • Radiotherapy, San Raffaele Scientific Institute, Milan, Italy
  • ,
  • Luigi Gianolli

      Affiliations

    • Nuclear Medicine, San Raffaele Scientific Institute, Milan, Italy
  • ,
  • Maria Carla Gilardi

      Affiliations

    • Nuclear Medicine, San Raffaele Scientific Institute, Milan, Italy
    • Center for Molecular Bioimaging, University of Milano-Bicocca, Milan, Italy
    • Institute for Bioimaging and Molecular Physiology, National Research Council, Milan, Italy
  • ,
  • Cristina Messa

      Affiliations

    • Center for Molecular Bioimaging, University of Milano-Bicocca, Milan, Italy
    • Institute for Bioimaging and Molecular Physiology, National Research Council, Milan, Italy
    • Nuclear Medicine, San Gerardo Hospital, Monza, Italy
    • L.A.T.O., HSR-Giglio, Cefalù, Italy

Received 4 June 2010 ,Revised 14 July 2010 ,Accepted 15 July 2010.

References 

  1. MacManus M, Nestle U, Rosenzweig KE, et al. Use of PET and PET/CT for radiation therapy planning: IAEA expert report 2006–2007. Radiother Oncol. 2009;91:85–94
  2. Abramyuk A, Tokalov S, Zophel K, et al. Is pre-therapeutical FDG-PET/CT capable to detect high risk tumor subvolumes responsible for local failure in non-small cell lung cancer?. Radiother Oncol. 2009;91:399–404
  3. Aerts HJ, van Baardwijk AA, Petit SF, et al. Identification of residual metabolic-active areas within individual NSCLC tumors using a pre-radiotherapy (18)fluorodeoxyglucose-PET–CT scan. Radiother Oncol. 2009;91:386–392
  4. Petit SF, Aerts HJ, van Loon JG, et al. Metabolic control probability in tumour subvolumes or how to guide tumour dose redistribution in non-small cell lung cancer (NSCLC): an exploratory clinical study. Radiother Oncol. 2009;91:393–398
  5. Vorwerk H, Beckmann G, Bremer M, et al. The delineation of target volumes for radiotherapy of lung cancer patients. Radiother Oncol. 2009;91:455–460
  6. Grosu AL, Piert M, Weber WA, et al. Positron emission tomography for radiation treatment planning. Strahlenther Onkol. 2005;181:483–499
  7. Keall PJ, Mageras GS, Balter JM, et al. The management of respiratory motion in radiation oncology report of AAPM Task Group 76. Med Phys. 2006;33:3874–3900
  8. Brandner ED, Wu A, Chen H, et al. Abdominal organ motion measured using 4D CT. Int J Radiat Oncol Biol Phys. 2006;65:554–560
  9. Chen GT, Kung JH, Beaudette KP. Artefacts in computed tomography scanning of moving objects. Semin Radiat Oncol. 2004;14:19–26
  10. Sureshbabu W, Mawlawi O. PET/CT imaging artefacts. J Nucl Med Technol. 2005;33:156–161[quiz 63–4]
  11. Nehmeh SA, Erdi YE, Ling CC, et al. Effect of respiratory gating on quantifying PET images of lung cancer. J Nucl Med. 2002;43:876–881
  12. Nehmeh SA, Erdi YE, Ling CC, et al. Effect of respiratory gating on reducing lung motion artifacts in PET imaging of lung cancer. Med Phys. 2002;29:366–371
  13. Erdi YE, Nehmeh SA, Pan T, et al. The CT motion quantitation of lung lesions and its impact on PET-measured SUVs. J Nucl Med. 2004;45:1287–1292
  14. Osman MM, Cohade C, Nakamoto Y, Wahl RL. Respiratory motion artefacts on PET emission images obtained using CT attenuation correction on PET–CT. Eur J Nucl Med Mol Imaging. 2003;30:603–606
  15. Pan T, Mawlawi O, Nehmeh SA, et al. Attenuation correction of PET images with respiration-averaged CT images in PET/CT. J Nucl Med. 2005;46:1481–1487
  16. Mawlawi O, Pan T, Macapinlac HA. PET/CT imaging techniques, considerations, and artefacts. J Thorac Imaging. 2006;21:99–110
  17. Nehmeh SA, Erdi YE, Pan T, et al. Four-dimensional (4D) PET/CT imaging of the thorax. Med Phys. 2004;31:3179–3186
  18. Boucher L, Rodrigue S, Lecomte R, Benard F. Respiratory gating for 3-dimensional PET of the thorax: feasibility and initial results. J Nucl Med. 2004;45:214–219
  19. Underberg RW, Lagerwaard FJ, Slotman BJ, Cuijpers JP, Senan S. Benefit of respiration-gated stereotactic radiotherapy for stage I lung cancer: an analysis of 4DCT datasets. Int J Radiat Oncol Biol Phys. 2005;62:554–560
  20. Park SJ, Ionascu D, Killoran J, et al. Evaluation of the combined effects of target size, respiratory motion and background activity on 3D and 4D PET/CT images. Phys Med Biol. 2008;53:3661–3679
  21. Li G, Citrin D, Camphausen K, et al. Advances in 4D medical imaging and 4D radiation therapy. Technol Cancer Res Treat. 2008;7:67–81
  22. Berman AT, Rengan R. New approaches to radiotherapy as definitive treatment for inoperable lung cancer. Semin Thorac Cardiovasc Surg. 2008;20:188–197
  23. van der Geld YG, Senan S, de Koste JR, et al. Evaluating mobility for radiotherapy planning of lung tumors: a comparison of virtual fluoroscopy and 4DCT. Lung Cancer. 2006;53:31–37
  24. Zhao B, Yang Y, Li T, et al. Image-guided respiratory-gated lung stereotactic body radiotherapy: which target definition is optimal?. Med Phys. 2009;36:2248–2257
  25. Nehmeh SA, Erdi YE. Respiratory motion in positron emission tomography/computed tomography: a review. Semin Nucl Med. 2008;38:167–176
  26. Keall PJ, Starkschall G, Shukla H, et al. Acquiring 4D thoracic CT scans using a multislice helical method. Phys Med Biol. 2004;49:2053–2067
  27. Pan T, Lee TY, Rietzel E, Chen GT. 4D-CT imaging of a volume influenced by respiratory motion on multi-slice CT. Med Phys. 2004;31:333–340
  28. Pan T. Comparison of helical and cine acquisitions for 4D-CT imaging with multislice CT. Med Phys. 2005;32:627–634
  29. Wink N, Panknin C, Solberg TD. Phase versus amplitude sorting of 4D-CT data. J Appl Clin Med Phys. 2006;7:77–85
  30. Abdelnour AF, Nehmeh SA, Pan T, et al. Phase and amplitude binning for 4D-CT imaging. Phys Med Biol. 2007;52:3515–3529
  31. Dawood M, Buther F, Lang N, Schober O, Schafers KP. Respiratory gating in positron emission tomography: a quantitative comparison of different gating schemes. Med Phys. 2007;34:3067–3076
  32. Dawood M, Buther F, Stegger L, et al. Optimal number of respiratory gates in positron emission tomography: a cardiac patient study. Med Phys. 2009;36:1775–1784
  33. Kini VR, Vedam SS, Keall PJ, et al. Patient training in respiratory-gated radiotherapy. Med Dosim. 2003;28:7–11
  34. Beddar AS, Briere TM, Balter P, et al. 4D-CT imaging with synchronized intravenous contrast injection to improve delineation of liver tumors for treatment planning. Radiother Oncol. 2008;87:445–448
  35. Mancosu P, Bettinardi V, Passoni P, et al. Contrast enhanced 4D-CT imaging for target volume definition in pancreatic ductal adenocarcinoma. Radiother Oncol. 2008;87:339–342
  36. Underberg RW, Lagerwaard FJ, Cuijpers JP, et al. Four-dimensional CT scans for treatment planning in stereotactic radiotherapy for stage I lung cancer. Int J Radiat Oncol Biol Phys. 2004;60:1283–1290
  37. Underberg RW, Lagerwaard FJ, Slotman BJ, Cuijpers JP, Senan S. Use of maximum intensity projections (MIP) for target volume generation in 4DCT scans for lung cancer. Int J Radiat Oncol Biol Phys. 2005;63:253–260
  38. Bradley JD, Nofal AN, El Naqa IM, et al. Comparison of helical, maximum intensity projection (MIP), and averaged intensity (AI) 4D CT imaging for stereotactic body radiation therapy (SBRT) planning in lung cancer. Radiother Oncol. 2006;81:264–268
  39. Muirhead R, McNee SG, Featherstone C, Moore K, Muscat S. Use of maximum intensity projections (MIPs) for target outlining in 4DCT radiotherapy planning. J Thorac Oncol. 2008;3:1433–1438
  40. Park K, Huang L, Gagne H, Papiez L. Do maximum intensity projection images truly capture tumor motion?. Int J Radiat Oncol Biol Phys. 2009;73:618–625
  41. Xi M, Liu MZ, Zhang L, et al. How many sets of 4DCT images are sufficient to determine internal target volume for liver radiotherapy?. Radiother Oncol. 2009;92:255–259
  42. Ehler ED, Tome WA. Lung 4D-IMRT treatment planning: an evaluation of three methods applied to four-dimensional data sets. Radiother Oncol. 2008;88:319–325
  43. Pevsner A, Nehmeh SA, Humm JL, Mageras GS, Erdi YE. Effect of motion on tracer activity determination in CT attenuation corrected PET images: a lung phantom study. Med Phys. 2005;32:2358–2362
  44. Vines DC, Keller H, Hoisak JD, Breen SL. Quantitative PET comparing gated with nongated acquisitions using a NEMA phantom with respiratory-simulated motion. J Nucl Med Technol. 2007;35:246–251
  45. Mancosu P, Sghedoni R, Bettinardi V, et al. 4D-PET data sorting into different number of phases: a NEMA IQ phantom study. J Appl Clin Med Phys. 2009;10:2917
  46. Rietzel E, Liu AK, Doppke KP, et al. Design of 4D treatment planning target volumes. Int J Radiat Oncol Biol Phys. 2006;66:287–295
  47. Hof H, Rhein B, Haering P, et al. 4D-CT-based target volume definition in stereotactic radiotherapy of lung tumours: comparison with a conventional technique using individual margins. Radiother Oncol. 2009;93:419–423
  48. D’Souza WD, Nazareth DP, Zhang B, et al. The use of gated and 4D CT imaging in planning for stereotactic body radiation therapy. Med Dosim. 2007;32:92–101
  49. Wang L, Hayes S, Paskalev K, et al. Dosimetric comparison of stereotactic body radiotherapy using 4D CT and multiphase CT images for treatment planning of lung cancer: evaluation of the impact on daily dose coverage. Radiother Oncol. 2009;91:314–324

PII: S0167-8140(10)00421-4

doi: 10.1016/j.radonc.2010.07.014

Radiotherapy & Oncology
Volume 96, Issue 3 , Pages 311-316 , September 2010