Radiotherapy & Oncology
Volume 97, Issue 2 , Pages 217-224 , November 2010

Dynamic contrast-enhanced magnetic resonance imaging of human cervical carcinoma xenografts: Pharmacokinetic analysis and correlation to tumor histomorphology

Received 24 December 2009 ,Revised 10 June 2010 ,Accepted 22 June 2010.

References 

  1. Rose PG, Bundy BN, Watkins EB, et al. Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N Engl J Med. 1999;340:1144–1153
  2. Green JA, Kirwan JM, Tierney JF, et al. Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and metaanalysis. Lancet. 2001;358:781–786
  3. Fyles AW, Milosevic M, Wong R, et al. Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother Oncol. 1998;48:149–156
  4. Sundfør K, Lyng H, Tropé CG, Rofstad EK. Treatment outcome in advanced squamous cell carcinoma of the uterine cervix: relationships to pretreatment tumor oxygenation and vascularization. Radiother Oncol. 2000;54:101–107
  5. Zahra MA, Hollingsworth KG, Sala E, et al. Dynamic contrast-enhanced MRI as a predictor of tumour response to radiotherapy. Lancet Oncol. 2007;8:63–74
  6. Yuh WTC, Mayr NA, Jarjoura D, et al. Predicting control of primary tumor and survival by DCE MRI during early therapy in cervical cancer. Invest Radiol. 2009;44:343–350
  7. Yamashita Y, Takahashi M, Sawada T, Miyazaki T, Okamura H. Carcinoma of the cervix: dynamic MR imaging. Radiology. 1992;182:643–648
  8. Hawighorst H, Knapstein PG, Weikel W, et al. Angiogenesis of uterine cervical carcinoma: characterization by pharmacokinetic magnetic resonance parameters and histological microvessel density with correlation to lymphatic involvement. Cancer Res. 1997;57:4777–4786
  9. Hawighorst H, Weikel W, Knapstein PG, et al. Angiogenic activity of cervical carcinoma: assessment by functional magnetic resonance imaging-based parameters and a histomorphological approach in correlation with disease outcome. Clin Cancer Res. 1998;4:2305–2312
  10. Yamashita Y, Baba T, Baba Y, et al. Dynamic contrast-enhanced MR imaging of uterine cervical cancer: pharmacokinetic analysis with histopathologic correlation and its importance in predicting the outcome of radiation therapy. Radiology. 2000;216:803–809
  11. Cooper RA, Carrington BM, Loncaster JA, et al. Tumour oxygenation levels correlate with dynamic contrast-enhanced magnetic resonance imaging parameters in carcinoma of the cervix. Radiother Oncol. 2000;57:53–55
  12. Lyng H, Vorren AO, Sundfør K, Taksdal I, Lien HH, Rofstad EK. Assessment of tumor oxygenation in human cervical carcinoma by use of dynamic Gd-DTPA-enhanced MR imaging. J Magn Reson Imaging. 2001;14:750–756
  13. Zahra MA, Tan LT, Priest AN, et al. Semiquantitative and quantitative dynamic contrast-enhanced magnetic resonance imaging measurements predict radiation response in cervix cancer. Int J Radiat Oncol Biol Phys. 2009;74:766–773
  14. Semple SIK, Harry VN, Parkin DE, Gilbert FJ. A combined pharmacokinetic and radiologic assessment of dynamic contrast-enhanced magnetic resonance imaging predicts response to chemoradiation in locally advanced cervical cancer. Int J Radiat Oncol Biol Phys. 2009;75:611–617
  15. Ellingsen C, Natvig I, Gaustad JV, Gulliksrud K, Egeland TAM, Rofstad EK. Human cervical carcinoma xenograft models for studies of the physiological microenvironment of tumors. J Cancer Res Clin Oncol. 2009;135:1177–1184
  16. Ellingsen C, Egeland TAM, Gulliksrud K, Gaustad JV, Mathiesen B, Rofstad EK. Assessment of hypoxia in human cervical carcinoma xenografts by dynamic contrast-enhanced magnetic resonance imaging. Int J Radiat Oncol Biol Phys. 2009;73:838–845
  17. Vestvik IK, Egeland TAM, Gaustad JV, Mathiesen B, Rofstad EK. Assessment of microvascular density, extracellular volume fraction, and radiobiological hypoxia in human melanoma xenografts by dynamic contrast-enhanced MRI. J Magn Reson Imaging. 2007;26:1033–1042
  18. Hittmair K, Gomiscek G, Langenberger K, et al. Method for the quantitative assessment of contrast agent uptake in dynamic contrast-enhanced MRI. Magn Reson Med. 1994;31:567–571
  19. Benjaminsen IC, Graff BA, Brurberg KG, Rofstad EK. Assessment of tumor blood perfusion by high-resolution dynamic contrast-enhanced MRI: a preclinical study of human melanoma xenografts. Magn Reson Med. 2004;52:269–276
  20. Tofts PS, Brix G, Buckley DL, et al. Estimating kinetic parameters from dynamic contrast-enhanced T1-weighted MRI of a diffusible tracer: standardized quantities and symbols. J Magn Reson Imaging. 1999;10:223–232
  21. Egeland TAM, Simonsen TG, Gaustad JV, Gulliksrud K, Ellingsen C, Rofstad EK. Dynamic contrast-enhanced magnetic resonance imaging of tumors: preclinical validation of parametric images. Radiat Res. 2009;172:339–347
  22. Rofstad EK, Halsør EF. Vascular endothelial growth factor, interleukin-8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts. Cancer Res. 2000;60:4932–4938
  23. Gaustad JV, Benjaminsen IC, Ruud EBM, Rofstad EK. Dynamic contrast-enhanced magnetic resonance imaging of human melanoma xenografts with necrotic regions. J Magn Reson Imaging. 2007;26:133–143
  24. Egeland TAM, Gaustad JV, Vestvik IK, Benjaminsen IC, Mathiesen B, Rofstad EK. Assessment of fraction of radiobiologically hypoxic cells in human melanoma xenografts by dynamic contrast-enhanced MRI. Magn Reson Med. 2006;55:874–882
  25. Egeland TAM, Gaustad JV, Benjaminsen IC, Hedalen K, Mathiesen B, Rofstad EK. Assessment of fraction of hypoxic cells in human tumor xenografts with necrotic regions by dynamic contrast-enhanced MRI. Radiat Res. 2008;169:689–699
  26. Gulliksrud K, Brurberg KG, Rofstad EK. Dynamic contrast-enhanced magnetic resonance imaging of tumor interstitial fluid pressure. Radiother Oncol. 2009;91:107–113
  27. Brurberg KG, Benjaminsen IC, Dørum LMR, Rofstad EK. Fluctuations in tumor blood perfusion assessed by dynamic-contrast enhanced MRI. Magn Reson Med. 2007;58:473–481
  28. Benjaminsen IC, Melås EA, Mathiesen BS, Rofstad EK. Limitations of dynamic contrast-enhanced MRI in monitoring radiation-induced changes in the fraction of radiobiologically hypoxic cells in human melanoma xenografts. J Magn Reson Imaging. 2008;28:1209–1218

PII: S0167-8140(10)00398-1

doi: 10.1016/j.radonc.2010.06.011

Radiotherapy & Oncology
Volume 97, Issue 2 , Pages 217-224 , November 2010

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