Curative chemoradiotherapy for isolated retroperitoneal lymph node recurrence of colorectal cancer
Received 15 December 2009; received in revised form 3 May 2010; accepted 18 May 2010. published online 28 July 2010. Corrected Proof
Abstract
Purpose
To investigate the efficacy of curative chemoradiotherapy for isolated retroperitoneal lymph node recurrence of colorectal cancer.
Materials and methods
Twenty-two colorectal cancer patients who received three-dimensional conformal radiotherapy (n=20) or helical tomotherapy (n=2) for isolated retroperitoneal lymph node recurrence were analyzed retrospectively. Radiation dose was 55.8Gy in 31 fractions or 63Gy in 35 fractions, and 60Gy in 20 fractions by helical tomotherapy. All patients received concurrent chemotherapy and 16 (72.7%) received adjuvant chemotherapy.
Results
The treatment response was complete in 13 (59.1%), partial in 6 (27.3%), and stable in 3 (13.6%) patients. Median follow-up for 11 (50%) surviving patients was 32months (range, 27–61). The 3- and 5-year overall survival rates were 64.7% and 36.4%, and median overall survival was 41months. Recurrences developed in 15 (68.2%) patients; outside the retroperitoneum in 13. The 3- and 5-year recurrence-free survival rates were 34.1% and 25.6%, and median recurrence-free survival was 20months. Response and adjuvant chemotherapy were significant prognostic factors for overall survival. Gastrointestinal toxicity⩾Grade 3 was not observed.
Conclusions
Definitive chemoradiotherapy is an effective salvage treatment for isolated retroperitoneal lymph node recurrence of colorectal cancer without severe complications.
aResearch Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
bDepartment of Radiation Oncology, Soonchunhyang University College of Medicine, Cheonan, Republic of Korea
cDepartment of Oncology, University of Ulsan College of Medicine, Seoul, Republic of Korea
Corresponding author. Address: Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 410-769, Republic of Korea.
ABSTRACT
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