Radiotherapy & Oncology
Volume 97, Issue 2 , Pages 307-311, November 2010

Curative chemoradiotherapy for isolated retroperitoneal lymph node recurrence of colorectal cancer

  • Seung-Gu Yeo

      Affiliations

    • Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
    • Department of Radiation Oncology, Soonchunhyang University College of Medicine, Cheonan, Republic of Korea
  • ,
  • Dae Yong Kim

      Affiliations

    • Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
    • Corresponding Author InformationCorresponding author. Address: Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 410-769, Republic of Korea.
  • ,
  • Tae Hyun Kim

      Affiliations

    • Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
  • ,
  • Kyung Hae Jung

      Affiliations

    • Department of Oncology, University of Ulsan College of Medicine, Seoul, Republic of Korea
  • ,
  • Yong Sang Hong

      Affiliations

    • Department of Oncology, University of Ulsan College of Medicine, Seoul, Republic of Korea
  • ,
  • Sun Young Kim

      Affiliations

    • Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
  • ,
  • Ji Won Park

      Affiliations

    • Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
  • ,
  • Hyo Seong Choi

      Affiliations

    • Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
  • ,
  • Jae Hwan Oh

      Affiliations

    • Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea

Received 15 December 2009; received in revised form 3 May 2010; accepted 18 May 2010. published online 28 July 2010.

Abstract 

Purpose

To investigate the efficacy of curative chemoradiotherapy for isolated retroperitoneal lymph node recurrence of colorectal cancer.

Materials and methods

Twenty-two colorectal cancer patients who received three-dimensional conformal radiotherapy (n=20) or helical tomotherapy (n=2) for isolated retroperitoneal lymph node recurrence were analyzed retrospectively. Radiation dose was 55.8Gy in 31 fractions or 63Gy in 35 fractions, and 60Gy in 20 fractions by helical tomotherapy. All patients received concurrent chemotherapy and 16 (72.7%) received adjuvant chemotherapy.

Results

The treatment response was complete in 13 (59.1%), partial in 6 (27.3%), and stable in 3 (13.6%) patients. Median follow-up for 11 (50%) surviving patients was 32months (range, 27–61). The 3- and 5-year overall survival rates were 64.7% and 36.4%, and median overall survival was 41months. Recurrences developed in 15 (68.2%) patients; outside the retroperitoneum in 13. The 3- and 5-year recurrence-free survival rates were 34.1% and 25.6%, and median recurrence-free survival was 20months. Response and adjuvant chemotherapy were significant prognostic factors for overall survival. Gastrointestinal toxicityGrade 3 was not observed.

Conclusions

Definitive chemoradiotherapy is an effective salvage treatment for isolated retroperitoneal lymph node recurrence of colorectal cancer without severe complications.

Keywords: Isolated, Retroperitoneal lymph node, Recurrence, Oligometastasis, Colorectal cancer, Chemoradiotherapy

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PII: S0167-8140(10)00396-8

doi:10.1016/j.radonc.2010.05.021

Radiotherapy & Oncology
Volume 97, Issue 2 , Pages 307-311, November 2010