Radiotherapy & Oncology
Volume 97, Issue 1 , Pages 60-64 , October 2010

High-dose preoperative chemoradiotherapy in esophageal cancer patients does not increase postoperative pulmonary complications: Correlation with dose–volume histogram parameters

  • Meysan Hurmuzlu

      Affiliations

    • Department of Oncology, Førde Central Hospital, Førde, Norway
    • Department of Surgical Sciences, University of Bergen, Norway
    • Corresponding Author InformationCorresponding author. Address: Department of Surgical Sciences, University of Bergen, N-5021 Bergen, Norway.
    • ,
  • Kjell Øvrebø

      Affiliations

    • Department of Surgery, Haukeland University Hospital, Bergen, Norway
    • Department of Surgical Sciences, University of Bergen, Norway
    • ,
  • Tore Wentzel-Larsen

      Affiliations

    • Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway
    • ,
  • Ludvig Paul Muren

      Affiliations

    • Department of Medical Physics, Aarhus University Hospital, Aarhus C, Denmark
    • ,
  • Asgaut Viste

      Affiliations

    • Department of Surgery, Haukeland University Hospital, Bergen, Norway
    • Department of Surgical Sciences, University of Bergen, Norway
    • ,
  • Rune Smaaland

      Affiliations

    • Department of Oncology and Hematology, Stavanger University Hospital, Stavanger, Norway

Received 18 December 2009 ,Revised 26 May 2010 ,Accepted 21 June 2010.

References 

  1. Swisher SG, Deford L, Merriman KW, et al. Effect of operative volume on morbidity, mortality, and hospital use after esophagectomy for cancer. J Thorac Cardiovasc Surg. 2000;119:1126–1132
  2. Whooley BP, Law S, Murthy SC, Alexandrou A, Wong J. Analysis of reduced death and complication rates after esophageal resection. Ann Surg. 2001;233:338–344
  3. Dimick JB, Goodney PP, Orringer MB, Birkmeyer JD. Specialty training and mortality after esophageal cancer resection. Ann Thorac Surg. 2005;80:282–286
  4. Hulscher JB, Tijssen JG, Obertop H, Van Lanschot JJ. Transthoracic versus transhiatal resection for carcinoma of the esophagus: a meta-analysis. Ann Thorac Surg. 2001;72:306–313
  5. Omloo JM, Law SY, Launois B, et al. Short- and long-term advantages of transhiatal and transthoracic oesophageal cancer resection. Eur J Surg Oncol. 2009;35:793–797
  6. Walsh TN, Noonan N, Hollywood D, Kelly A, Keeling N, Hennessy TP. A comparison of multimodal therapy and surgery for esophageal adenocarcinoma. N Engl J Med. 1996;335:462–467
  7. Gebski V, Burmeister B, Smithers BM, Foo K, Zalcberg J, Simes J. Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: a meta-analysis. Lancet Oncol. 2007;8:226–234
  8. Rooney M, Kish J, Jacobs J, et al. Improved complete response rate and survival in advanced head and neck cancer after three-course induction therapy with 120-h 5-FU infusion and cisplatin. Cancer. 1985;55:1123–1128
  9. Bedford JL, Viviers L, Guzel Z, Childs PJ, Webb S, Tait DM. A quantitative treatment planning study evaluating the potential of dose escalation in conformal radiotherapy of the esophagus. Radiother Oncol. 2000;57:183–193
  10. Levendag PC, Nowak PJ, Van der Sangen MJ, et al. Local tumor control in radiation therapy of cancers in the head and neck. Am J Clin Oncol. 1996;19:469–477
  11. Thames HD, Peters LJ, Spanos W, Fletcher GF. Dose–response of squamous cell carcinomas of the upper respiratory and digestive tracts. Br J Cancer Suppl. 1980;4:35–38
  12. Sobin LH, Wittekind C. International Union against Cancer: TNM: classification of malignant tumours. 6th ed.. New York: Wiley-Liss; 2002;
  13. Wang SL, Liao Z, Vaporciyan AA, et al. Investigation of clinical and dosimetric factors associated with postoperative pulmonary complications in esophageal cancer patients treated with concurrent chemoradiotherapy followed by surgery. Int J Radiat Oncol Biol Phys. 2006;64:692–699
  14. CDC definitions for nosocomial infections, 1988. Am Rev Respir Dis. 1989;139:1058–1059
  15. Kress John P, Hall Jesse B. Principles of critical care medicine [chapter 261]. In Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J, editors. Harrison’s principles of internal medicine. 17th ed.; 2008. Available from: http://www.accessmedicine.com/content.aspx?aID=2862160.
  16. Law S, Wong KH, Kwok KF, Chu KM, Wong J. Predictive factors for postoperative pulmonary complications and mortality after esophagectomy for cancer. Ann Surg. 2004;240:791–800
  17. Doty JR, Salazar JD, Forastiere AA, Heath EI, Kleinberg L, Heitmiller RF. Postesophagectomy morbidity, mortality, and length of hospital stay after preoperative chemoradiation therapy. Ann Thorac Surg. 2002;74:227–231[discussion 231]
  18. Lin FC, Durkin AE, Ferguson MK. Induction therapy does not increase surgical morbidity after esophagectomy for cancer. Ann Thorac Surg. 2004;78:1783–1789
  19. Keller SM, Ryan LM, Coia LR, et al. High dose chemoradiotherapy followed by esophagectomy for adenocarcinoma of the esophagus and gastroesophageal junction: results of a phase II study of the Eastern Cooperative Oncology Group. Cancer. 1998;83:1908–1916
  20. Bosset JF, Gignoux M, Triboulet JP, et al. Chemoradiotherapy followed by surgery compared with surgery alone in squamous-cell cancer of the esophagus. N Engl J Med. 1997;337:161–167
  21. Abou-Jawde RM, Mekhail T, Adelstein DJ, et al. Impact of induction concurrent chemoradiotherapy on pulmonary function and postoperative acute respiratory complications in esophageal cancer. Chest. 2005;128:250–255
  22. Eguchi R, Ide H, Nakamura T, et al. Analysis of postoperative complications after esophagectomy for esophageal cancer in patients receiving neoadjuvant therapy. Jpn J Thorac Cardiovasc Surg. 1999;47:552–558
  23. Burmeister BH, Smithers BM, Gebski V, et al. Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trial. Lancet Oncol. 2005;6:659–668
  24. Willner J, Jost A, Baier K, Flentje M. A little to a lot or a lot to a little? An analysis of pneumonitis risk from dose–volume histogram parameters of the lung in patients with lung cancer treated with 3D conformal radiotherapy. Strahlenther Onkol. 2003;179:548–556
  25. Tandon S, Batchelor A, Bullock R, et al. Peri-operative risk factors for acute lung injury after elective oesophagectomy. Br J Anaesth. 2001;86:633–638
  26. Cui Y. Pulmonary complication after esophagectomy results from multiple factors. Ann Thorac Surg. 2002;74:1747
  27. Lee HK, Vaporciyan AA, Cox JD, et al. Postoperative pulmonary complications after preoperative chemoradiation for esophageal carcinoma: correlation with pulmonary dose–volume histogram parameters. Int J Radiat Oncol Biol Phys. 2003;57:1317–1322
  28. Dahn D, Martell J, Vorwerk H, et al. Influence of irradiated lung volumes on perioperative morbidity and mortality in patients after neoadjuvant radiochemotherapy for esophageal cancer. Int J Radiat Oncol Biol Phys. 2009;77:44–52
  29. Fiorica F, Di Bona D, Schepis F, et al. Preoperative chemoradiotherapy for oesophageal cancer: a systematic review and meta-analysis. Gut. 2004;53:925–930
  30. Urschel JD, Vasan H. A meta-analysis of randomized controlled trials that compared neoadjuvant chemoradiation and surgery to surgery alone for resectable esophageal cancer. Am J Surg. 2003;185:538–543
  31. Hsu FM, Lee YC, Lee JM, et al. Association of clinical and dosimetric factors with postoperative pulmonary complications in esophageal cancer patients receiving intensity-modulated radiation therapy and concurrent chemotherapy followed by thoracic esophagectomy. Ann Surg Oncol. 2009;16:1669–1677

PII: S0167-8140(10)00392-0

doi: 10.1016/j.radonc.2010.06.008

Radiotherapy & Oncology
Volume 97, Issue 1 , Pages 60-64 , October 2010

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