Prone versus supine positioning for whole and partial-breast radiotherapy: A comparison of non-target tissue dosimetry
Received 14 January 2010; received in revised form 17 May 2010; accepted 23 May 2010. published online 21 June 2010.
Abstract
Purpose
To compare non-target tissue (including left-anterior-descending coronary-artery (LAD)) dosimetry of prone versus supine whole (WBI) and partial-breast irradiation (PBI).
Methods and materials
Sixty-five post-lumpectomy breast cancer patients underwent CT-imaging supine and prone. On each dataset, the whole-breast clinical-target-volume (WB-CTV), partial-breast CTV (tumour-bed+15mm), ipsilateral-lung and chest-wall were outlined. Heart and LAD were outlined in left-sided cases (n=30). Tangential-field WBI and PBI plans were generated for each position. Mean LAD, heart, and ipsilateral-lung doses (xmean), maximum LAD (LADmax) doses, and the volume of chest-wall receiving 50Gy (V50Gy) were compared.
Results
Two-hundred and sixty plans were generated. Prone positioning reduced heart and LAD doses in 19/30 WBI cases (median reduction in LADmean=6.2Gy) and 7/30 PBI cases (median reduction in LADmax=29.3Gy) (no difference in 4/30 cases). However, prone positioning increased cardiac doses in 8/30 WBI (median increase in LADmean=9.5Gy) and 19/30 PBI cases (median increase in LADmax=22.9Gy) (no difference in 3/30 cases). WB-CTV>1000cm3 was associated with improved cardiac dosimetry in the prone position for WBI (p=0.04) and PBI (p=0.04). Prone positioning reduced ipsilateral-lungmean in 65/65 WBI and 61/65 PBI cases, and chest-wall V50Gy in all WBI cases. PBI reduced normal-tissue doses compared to WBI in all cases, regardless of the treatment position.
Conclusions
In the context of tangential-field WBI and PBI, prone positioning is likely to benefit left-breast-affected women of larger breast volume, but to be detrimental in left-breast-affected women of smaller breast volume. Right-breast-affected women are likely to benefit from prone positioning regardless of breast volume.
Corresponding author. Address: Department of Academic Radiotherapy, Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT, United Kingdom.
ABSTRACT