Radiotherapy & Oncology
Volume 97, Issue 1 , Pages 76-79 , October 2010

Dose volume parameter D2cc does not correlate with vaginal side effects in individual patients with cervical cancer treated within a defined treatment protocol with very high brachytherapy doses

  • Elena F. Fidarova

      Affiliations

    • Department of Radiotherapy, Medical University of Vienna, Vienna, Austria
    • Corresponding Author InformationCorresponding author. Address: Department of Radiotherapy, Medical University of Vienna, General Hospital of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
    • ,
  • Daniel Berger

      Affiliations

    • Department of Radiotherapy, Medical University of Vienna, Vienna, Austria
    • ,
  • Sandra Schüssler

      Affiliations

    • Department of Radiotherapy, Medical University of Vienna, Vienna, Austria
    • Department of Radiotherapy, Christian-Albrechts University Kiel, Kiel, Germany
    • ,
  • Johannes Dimopoulos

      Affiliations

    • Department of Radiotherapy, Medical University of Vienna, Vienna, Austria
    • ,
  • Christian Kirisits

      Affiliations

    • Department of Radiotherapy, Medical University of Vienna, Vienna, Austria
    • ,
  • Petra Georg

      Affiliations

    • Department of Radiotherapy, Medical University of Vienna, Vienna, Austria
    • ,
  • Barbara Bachtiary

      Affiliations

    • Department of Radiotherapy, Medical University of Vienna, Vienna, Austria
    • ,
  • Richard Pötter

      Affiliations

    • Department of Radiotherapy, Medical University of Vienna, Vienna, Austria

Received 17 November 2009 ,Revised 12 April 2010 ,Accepted 16 May 2010.

References 

  1. Pötter R, Dimopoulos J, Georg P, et al. Clinical impact of MRI assisted dose volume adaptation and dose escalation in brachytherapy of locally advanced cervix cancer. Radiother Oncol. 2007;83:148–155
  2. Chargari C, Magné N, Dumas I, et al. Physics contributions and clinical outcome with 3D-MRI-based pulsed-dose-rate intracavitary brachytherapy in cervical cancer patients. Int J Radiat Oncol Biol Phys. 2009;74:133–139
  3. Bergmark K, Avall-Lundqvist E, Dickman PW, Henningsohn L, Steineck G. Vaginal changes and sexuality in women with history of cervical cancer. N Engl J Med. 1999;340:1383–1389
  4. Bruner DW, Lanciano R, Keegan M, Corn B, Martin E, Hanks GE. Vaginal stenosis and sexual function following intracavitary radiation for the treatment of cervical and endometrial carcinoma. Int J Radiat Oncol Biol Phys. 1993;27:825–830
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  8. Grigsby PW, Russell A, Bruner D, et al. Late injury of cancer therapy on the female reproductive tract. Int J Radiat Oncol Biol Phys. 1995;31:1281–1299
  9. Hintz BL, Kagan AR, Chan P, et al. Radiation tolerance of the vaginal mucosa. Int J Radiat Oncol Biol Phys. 1980;6:711–716
  10. Au SP, Grigsby PW. The irradiation tolerance dose of the proximal vagina. Radiother Oncol. 2003;67:77–85
  11. Pötter R, Haie-Meder C, Van Limbergen E, et al. Recommendations from Gynaecological (GYN) GEC ESTRO Working Group (II): concepts and terms in 3D image based treatment planning in cervix cancer brachytherapy: aspects of 3D imaging, radiation physics, radiobiology, and 3D dose volume parameters. Radiother Oncol. 2006;78:67–77
  12. Kirisits C, Pötter R, Lang S, Dimopoulos J, Wachter-Gerstner N, Georg D. Dose and volume parameters for MRI based treatment planning in intracavitary brachytherapy of cervix cancer. Int J Radiat Oncol Biol Phys. 2005;62:901–911
  13. De Brabandere M, Mousa AG, Nulens A, Swinnen A, Van Limbergen E. Potential of dose optimisation in MRI-based PDR brachytherapy of cervix carcinoma. Radiother Oncol. 2008;88:217–226
  14. Lindegaard JC, Tanderup K, Nielsen SK, Haack S, Gelineck J. MRI-guided 3D optimization significantly improves DVH parameters of pulsed-dose-rate brachytherapy in locally advanced cervical cancer. Int J Radiat Oncol Biol Phys. 2008;71:756–764
  15. Georg P, Kirisits C, Goldner G, et al. Correlation of dose–volume parameters, endoscopic and clinical rectal side effects in cervix cancer patients treated with definitive radiotherapy including MRI-based brachytherapy. Radiother Oncol. 2009;91:173–180
  16. Koom WS, Sohn DK, Kim JY, et al. Computed tomography-based high-dose-rate intracavitary brachytherapy for uterine cervical cancer: preliminary demonstration of correlation between dose–volume parameters and rectal mucosal changes observed by flexible sigmoidoscopy. Int J Radiat Oncol Biol Phys. 2007;68:1446–1454
  17. Berger D, Dimopoulos J, Georg P, Georg D, Pötter R, Kirisits C. Uncertainties in assessment of the vaginal dose for intracavitary brachytherapy of cervical cancer using a tandem-ring applicator. Int J Radiat Oncol Biol Phys. 2007;67:1451–1459
  18. Dimopoulos JCA, Schard G, Berger D, et al. Systematic evaluation of MRI findings in different stages of treatment of cervical cancer: potential of MRI on delineation of target, pathoanatomic structures, and organs at risk. Int J Radiat Oncol Biol Phys. 2006;64:1380–1388
  19. Lang S, Kirisits C, Dimopoulos J, Georg D, Pötter R. Treatment planning for MRI assisted brachytherapy of gynecologic malignancies based on total dose constraints. Int J Radiat Oncol Biol Phys. 2007;69:619–627
  20. LENT–SOMA tables. Int J Radiat Oncol Biol Phys 1995;31:1048–92.
  21. Schüssler S. Korrelation von Dosis–Volumen-Parametern und klinischen Veränderungen an der Vagina bei Patientinnen mit Zervixkarzinom nach primärer Radiotherapie. Thesis, Christian Albrechts University Kiel; 2007.
  22. Fidarova E, Schüssler S, Dimopoulos J, et al. An investigation into the relationship between MRI-based DVH parameters and vaginal morbidity in cervical cancer brachytherapy. Radiother Oncol. 2008;88:S238
  23. Berger D, Fidarova E, Dumas I, et al. Concept, feasibility and results of vaginal dose mapping for different brachytherapy treatment techniques and dose rates for cervical cancer patients. Radiother Oncol. 2009;91:S34–S35

PII: S0167-8140(10)00309-9

doi: 10.1016/j.radonc.2010.05.005

Radiotherapy & Oncology
Volume 97, Issue 1 , Pages 76-79 , October 2010

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