Radiotherapy & Oncology
Volume 96, Issue 1 , Pages 19-24 , July 2010

The potential role of G2- but not of G0-radiosensitivity for predisposition of prostate cancer

  • Kerstin Borgmann

      Affiliations

    • Laboratory of Radiobiology & Experimental Radiooncology, University Medical Center Hamburg-Eppendorf, Germany
    • ,
  • Annette Raabe

      Affiliations

    • Laboratory of Radiobiology & Experimental Radiooncology, University Medical Center Hamburg-Eppendorf, Germany
    • ,
  • Sebastian Reuther

      Affiliations

    • Laboratory of Radiobiology & Experimental Radiooncology, University Medical Center Hamburg-Eppendorf, Germany
    • ,
  • Silke Szymczak

      Affiliations

    • Institute of Medical Biometry and Statistics, University at Lübeck, University Hospital Schleswig-Holstein, Germany
    • ,
  • Thorsten Schlomm

      Affiliations

    • Department of Urology, University Medical Center Hamburg-Eppendorf, Germany
    • ,
  • Hendrik Isbarn

      Affiliations

    • Department of Urology, University Medical Center Hamburg-Eppendorf, Germany
    • ,
  • Maria Gomolka

      Affiliations

    • Department of Radiation Protection and Health, Federal Office for Radiation Protection, Oberschleissheim, Germany
    • ,
  • Andreas Busjahn

      Affiliations

    • HealthTwiSt GmbH, Berlin, Germany
    • ,
  • Michael Bonin

      Affiliations

    • Department of Medical Genetics, University of Tübingen, Germany
    • ,
  • Andreas Ziegler

      Affiliations

    • Institute of Medical Biometry and Statistics, University at Lübeck, University Hospital Schleswig-Holstein, Germany
    • ,
  • Ekkehard Dikomey

      Affiliations

    • Laboratory of Radiobiology & Experimental Radiooncology, University Medical Center Hamburg-Eppendorf, Germany
    • Corresponding Author InformationCorresponding author. Address: Laboratory of Radiobiology & Experimental Radiooncology, Campus Forschung, N27, Martinistraße 52, D-20246 Hamburg, Germany.

Received 7 December 2009 ,Revised 9 April 2010 ,Accepted 12 April 2010.

References 

  1. Bonassi S, Norppa H, Ceppi M, et al. Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22,358 subjects in 11 countries. Carcinogenesis. 2008;29:1178–1183
  2. Scott D. Chromosomal radiosensitivity and low penetrance predisposition to cancer. Cytogenet Genome Res. 2004;104:365–370
  3. Scott D, Spreadborough A, Levine E, Roberts SA. Genetic predisposition in breast cancer. Lancet. 1994;344:1444
  4. Baeyens A, Thierens H, Claes K, et al. Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition. Br J Cancer. 2002;87:1379–1385
  5. Baeyens A, Van Den Broecke R, Makar A, Thierens H, De Ridder L, Vral A. Chromosomal radiosensitivity in breast cancer patients: influence of age of onset of the disease. Oncol Rep. 2005;13:347–353
  6. Buchholz TA, Wu X. Radiation-induced chromatid breaks as a predictor of breast cancer risk. Int J Radiat Oncol Biol Phys. 2001;49:533–537
  7. Burrill W, Barber JB, Roberts SA, Bulman B, Scott D. Heritability of chromosomal radiosensitivity in breast cancer patients: a pilot study with the lymphocyte micronucleus assay. Int J Radiat Biol. 2000;76:1617–1619
  8. Howe OL, Daly PA, Seymour C, Ormiston W, Nolan C, Mothersill C. Elevated G2 chromosomal radiosensitivity in Irish breast cancer patients: a comparison with other studies. Int J Radiat Biol. 2005;81:373–378
  9. Mozdarani H, Mansouri Z, Haeri SA. Cytogenetic radiosensitivity of g0-lymphocytes of breast and esophageal cancer patients as determined by micronucleus assay. J Radiat Res. 2005;46:111–116
  10. Riches AC, Bryant PE, Steel CM, et al. Chromosomal radiosensitivity in G2-phase lymphocytes identifies breast cancer patients with distinctive tumour characteristics. Br J Cancer. 2001;85:1157–1161
  11. Roberts SA, Spreadborough AR, Bulman B, Barber JB, Evans DG, Scott D. Heritability of cellular radiosensitivity: a marker of low-penetrance predisposition genes in breast cancer?. Am J Hum Genet. 1999;65:784–794
  12. Scott D, Barber JB, Levine EL, Burrill W, Roberts SA. Radiation-induced micronucleus induction in lymphocytes identifies a high frequency of radiosensitive cases among breast cancer patients: a test for predisposition?. Br J Cancer. 1998;77:614–620
  13. Scott D, Barber JB, Spreadborough AR, Burrill W, Roberts SA. Increased chromosomal radiosensitivity in breast cancer patients: a comparison of two assays. Int J Radiat Biol. 1999;75:1–10
  14. Varga D, Hoegel J, Maier C, et al. On the difference of micronucleus frequencies in peripheral blood lymphocytes between breast cancer patients and controls. Mutagenesis. 2006;21:313–320
  15. Docherty Z, Georgiou A, Langman C, et al. Is chromosome radiosensitivity and apoptotic response to irradiation correlated with cancer susceptibility?. Int J Radiat Biol. 2007;83:1–12
  16. Baria K, Warren C, Roberts SA, West CM, Scott D. Chromosomal radiosensitivity as a marker of predisposition to common cancers?. Br J Cancer. 2001;84:892–896
  17. Bondy ML, Wang LE, El-Zein R, et al. Gamma-radiation sensitivity and risk of glioma. J Natl Cancer Inst. 2001;93:1553–1557
  18. Curwen GB, Winther JF, Tawn EJ, et al. G(2) chromosomal radiosensitivity in Danish survivors of childhood and adolescent cancer and their offspring. Br J Cancer. 2005;93:1038–1045
  19. De Ruyck K, de Gelder V, Van Eijkeren M, et al. Chromosomal radiosensitivity in head and neck cancer patients: evidence for genetic predisposition?. Br J Cancer. 2008;98:1723–1738
  20. Lisowska H, Lankoff A, Wieczorek A, et al. Enhanced chromosomal radiosensitivity in peripheral blood lymphocytes of larynx cancer patients. Int J Radiat Oncol Biol Phys. 2006;66:1245–1252
  21. Papworth R, Slevin N, Roberts SA, Scott D. Sensitivity to radiation-induced chromosome damage may be a marker of genetic predisposition in young head and neck cancer patients. Br J Cancer. 2001;84:776–782
  22. Borgmann K, Dede M, Wrona A, Brammer I, Overgaard J, Dikomey E. For X-irradiated normal human fibroblasts, only half of cell inactivation results from chromosomal damage. Int J Radiat Oncol Biol Phys. 2004;58:445–452
  23. Borgmann K, Haeberle D, Doerk T, Busjahn A, Stephan G, Dikomey E. Genetic determination of chromosomal radiosensitivities in G0- and G2-phase human lymphocytes. Radiother Oncol. 2007;83:196–202
  24. Busjahn A. HealthTwiSt: the Berlin twin registry. Twin Res Hum Genet. 2006;9:778–782
  25. Becker A, Busjahn A, Faulhaber HD, et al. Twin zygosity. Automated determination with microsatellites. J Reprod Med. 1997;42:260–266
  26. Hoeller U, Borgmann K, Bonacker M, et al. Individual radiosensitivity measured with lymphocytes may be used to predict the risk of fibrosis after radiotherapy for breast cancer. Radiother Oncol. 2003;69:137–144
  27. Cornforth MN, Bedford JS. A quantitative comparison of potentially lethal damage repair and the rejoining of interphase chromosome breaks in low passage normal human fibroblasts. Radiat Res. 1987;111:385–405
  28. Fraley C, Raftery AE. Model-based clustering, discriminant analysis, and density estimation. J Am Stat Assoc. 2002;97:611–631
  29. Cloos J, Nieuwenhuis EJ, Boomsma DI, et al. Inherited susceptibility to bleomycin-induced chromatid breaks in cultured peripheral blood lymphocytes. J Natl Cancer Inst. 1999;91:1125–1130
  30. Wu X, Spitz MR, Amos CI, et al. Mutagen sensitivity has high heritability: evidence from a twin study. Cancer Res. 2006;66:5993–5996
  31. Hartel C, Nikoghosyan A, Durante M, et al. Chromosomal aberrations in peripheral blood lymphocytes of prostate cancer patients treated with IMRT and carbon ions. Radiother Oncol. 2010;73:73–78
  32. Mansour WY, Schumacher S, Rosskopf R, et al. Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks. Nucleic Acids Res. 2008;36:4088–4098
  33. Takata M, Sasaki MS, Sonoda E, et al. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO J. 1998;17:5497–5508
  34. Rothkamm K, Kuhne M, Jeggo PA, Lobrich M. Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks. Cancer Res. 2001;61:3886–3893
  35. Parshad R, Sanford KK. Radiation-induced chromatid breaks and deficient DNA repair in cancer predisposition. Crit Rev Oncol Hematol. 2001;37:87–96
  36. Borgmann K, Hoeller U, Nowack S, et al. Individual radiosensitivity measured with lymphocytes may predict the risk of acute reaction after radiotherapy. Int J Radiat Oncol Biol Phys. 2008;71:256–264
  37. Borgmann K, Dikomey E, Petersen C, Feyer P, Hoeller U. Sex-specific aspects of tumor therapy. Radiat Environ Biophys. 2009;48:115–124
  38. Baker SG, Lichtenstein P, Kaprio J, Holm N. Genetic susceptibility to prostate, breast, and colorectal cancer among Nordic twins. Biometrics. 2005;61:55–63
  39. Mitchell EL, Scott D. G2 chromosomal radiosensitivity in fibroblasts of ataxia-telangiectasia heterozygotes and a Li–Fraumeni syndrome patient with radioresistant cells. Int J Radiat Biol. 1997;72:435–438
  40. Meyer A, Wilhelm B, Dork T, et al. ATM missense variant P1054R predisposes to prostate cancer. Radiother Oncol. 2007;83:283–288
  41. Dombernowsky SL, Weischer M, Allin KH, Bojesen SE, Tybjaerg-Hansen A, Nordestgaard BG. Risk of cancer by ATM missense mutations in the general population. J Clin Oncol. 2008;26:3057–3062
  42. Eeles RA, Kote-Jarai Z, Giles GG, et al. Multiple newly identified loci associated with prostate cancer susceptibility. Nat Genet. 2008;40:316–321
  43. Thomas G, Jacobs KB, Yeager M, et al. Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet. 2008;40:310–315
  44. Zheng SL, Sun J, Wiklund F, et al. Cumulative association of five genetic variants with prostate cancer. N Engl J Med. 2008;358:910–919

PII: S0167-8140(10)00261-6

doi: 10.1016/j.radonc.2010.04.018

Radiotherapy & Oncology
Volume 96, Issue 1 , Pages 19-24 , July 2010

Article Tools

* Image Usage & Resolution