Radiotherapy & Oncology
Volume 96, Issue 2 , Pages 161-165 , August 2010

MRI-based low dose-rate brachytherapy experience in locally advanced cervical cancer patients initially treated by concomitant chemoradiotherapy

  • Christine Haie-Meder

      Affiliations

    • Department of Radiotherapy – Brachytherapy Service, Institut Gustave Roussy, Villejuif, France
    • Corresponding Author InformationCorresponding author. Address: Institut Gustave-Roussy, Department of Radiotherapy – Brachytherapy Service, 39, rue Camille Desmoulins, 94805 Villejuif cedex, France.
    • ,
  • Cyrus Chargari

      Affiliations

    • Department of Radiotherapy – Brachytherapy Service, Institut Gustave Roussy, Villejuif, France
    • Department of Radiotherapy, Hôpital du Val-de-Grâce, Paris, France
    • ,
  • Annie Rey

      Affiliations

    • Department of Statistical Analysis, Institut Gustave Roussy, Villejuif, France
    • ,
  • Isabelle Dumas

      Affiliations

    • Department of Radiotherapy – Brachytherapy Service, Institut Gustave Roussy, Villejuif, France
    • ,
  • Philippe Morice

      Affiliations

    • Department of Surgical Oncology, Institut Gustave Roussy, Villejuif, France
    • ,
  • Nicolas Magné

      Affiliations

    • Department of Radiotherapy – Brachytherapy Service, Institut Gustave Roussy, Villejuif, France

Received 2 October 2009 ,Revised 25 March 2010 ,Accepted 7 April 2010.

References 

  1. Chargari C, Magné N, Dumas I, Messai T, Vicenzi L, Gillion N, et al. Physics contributions and clinical outcome with 3D-MRI-based pulsed-dose-rate intracavitary brachytherapy in cervical cancer patients. Int J Radiat Oncol Biol Phys. 2009;74:133–139
  2. De Brabandere M, Mousa AG, Nulens A, Swinnen A, Van Limbergen E. Potential of dose optimisation in MRI-based PDR brachytherapy of cervix carcinoma. Radiother Oncol. 2008;88:217–226
  3. Dimopoulos JC, Pötter R, Lang S, Fidarova E, Georg P, Dörr W, et al. Dose–effect relationship for local control of cervical cancer by magnetic resonance image-guided brachytherapy. Radiother Oncol. 2009;93:311–315
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  5. Fellner C, Pötter R, Knocke TH, Wambersie A. Comparison of radiography- and computed tomography-based treatment planning in cervix cancer in brachytherapy with specific attention to some quality assurance aspects. Radiother Oncol. 2001;58:53–62
  6. Georg D, Kirisits C, Hillbrand M, Dimopoulos J, Pötter R. Image-guided radiotherapy for cervix cancer: high-tech external beam therapy versus high-tech brachytherapy. Int J Radiat Oncol Biol Phys. 2008;71:1272–1278
  7. Gerbaulet A, Michel G, Haie-Meder C, et al. The role of low dose rate brachytherapy in the treatment of cervix carcinoma. Experience of the Gustave-Roussy Institute on 1245 patients. Eur J Gynaecol Oncol. 1995;16:461–475
  8. Gerbaulet A, Pötter R, Mazeron JJ, Meertens H, Van Limbergen E. The GEC-ESTRO handbook of brachytherapy. ESTRO. 2002;316–318
  9. Haie-Meder C, Chargari C, Rey A, Dumas I, Morice P, Magné N. DVH parameters and outcome for patients with early-stage cervical cancer treated with preoperative MRI-based low dose rate brachytherapy followed by surgery. Radiother Oncol. 2009;93:316–321
  10. Haie-Meder C, Peiffert D. Innovation in gynaecological brachytherapy new technologies, pulse dose-rate brachytherapy, image, definition of new volumes of interest and their impact on dosimetry application in a clinical research programme ‘STIC’. Cancer Radiother. 2006;10:402–409
  11. Haie-Meder C, Pötter R, Van Limbergen E, et al. Recommendations from the Gynaecological (GYN) GEC-ESTRO Working Group (I): concepts and terms in image based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTV. Radiother Oncol. 2005;74:235–245
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  13. Katz A, Eifel PJ. Quantification of intracavitary brachytherapy parameters and correlation with outcome in patients with carcinoma of the cervix. Int J Radiat Oncol Biol Phys. 2000;48:1417–1425
  14. Kirisits C, Pötter R, Lang S, et al. Dose and volume parameters for MRI-based treatment planning in intracavitary brachytherapy for cervical cancer. Int J Radiat Oncol Biol Phys. 2005;62:901–911
  15. Lindegaard JC, Tanderup K, Nielsen SK, Haack S, Gelineck J. MRI-guided optimization significantly improves DVH parameters of pulsed-dose rate brachytherapy in locally advanced cervical cancer. Int J Radiat Oncol Biol Phys. 2008;71:756–764
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  18. Pötter R, Dimopoulos J, Georg P, et al. Clinical impact of MRI assisted dose volume adaptation and dose escalation in brachytherapy of locally advanced cervix cancer. Radiother Oncol. 2007;83:148–155
  19. Pötter R, Haie-Meder C, Van Limbergen E, et al. Recommendations from gynaecological (GYN) GEC-ESTRO working group (II): concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy-3D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology. Radiother Oncol. 2006;78:67–77
  20. Viswanathan AN, Dimopoulos J, Kirisits C, Berger D, Pötter R. Computed tomography versus magnetic resonance imaging-based contouring in cervical cancer brachytherapy: results of a prospective trial and preliminary guidelines for standardized contours. Int J Radiat Oncol Biol Phys. 2007;68:491–498
  21. Zwahlen D, Jezioranski J, Chan P, et al. Magnetic resonance imaging-guided intracavitary brachytherapy for cancer of the cervix. Int J Radiat Oncol Biol Phys. 2009;74:1157–1164

PII: S0167-8140(10)00241-0

doi: 10.1016/j.radonc.2010.04.015

Radiotherapy & Oncology
Volume 96, Issue 2 , Pages 161-165 , August 2010

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