Radiotherapy & Oncology
Volume 95, Issue 3 , Pages 283-287 , June 2010

Impact of radiation dose on locoregional control and survival on squamous cell carcinoma of anal canal

Received 24 September 2009 ,Revised 6 April 2010 ,Accepted 6 April 2010.

References 

  1. Landis SH, Murray T, Bolden S. Cancer statistics, 1999. CA Cancer J Clin. 1999;49:8–31
  2. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2006. CA Cancer J Clin. 2006;56:106–130
  3. National Cancer Registry Report. ICMR; 2001–2004. p. 78–154.
  4. Miles E. A method of performing abdominoperineal excision for carcinoma of the rectum and of the terminal portion of the pelvic colon. Lancet. 1908;2:1812–1813
  5. Binkley GE. Epidermoid carcinoma of the anus and rectum: review of 125 cases. Am J Surg. 1950;79:90–95
  6. UKCCCR Anal Cancer Trial Working Party. Epidermoid anal cancer: results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin. UK Coordinating Committee on Cancer Research. Lancet. 1996;348:1049–1054
  7. Bartelink H, Roelofsen F, Eschwege F, et al. Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups. J Clin Oncol. 1997;15:2040–2049
  8. Flam M, John M, Pajak TF, et al. Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study. J Clin Oncol. 1996;14:2527–2539
  9. Cummings BJ, Keane TJ, O’Sullivan B, et al. Epidermoid anal cancer: treatment by radiation alone or by radiation and 5-fluorouracil with and without mitomycin C. Int J Radiat Oncol Biol Phys. 1991;21:1115–1125
  10. Green FL, Page DL, Flemming ID. American Joint Committee on cancer, cancer staging handbook. 6th ed.. New York: Springer; 2002;
  11. Peiffert D, Bey P, Pernot M, et al. Conservative treatment by irradiation of epidermoid cancers of the anal canal: prognostic factors of tumoral control and complications. Int J Radiat Oncol Biol Phys. 1997;37:313–324
  12. Widder J, Kastenberger R, Fercher E, Schmid R, Langendijk JA, Dobrowsky W, et al. Radiation dose associated with local control in advanced anal cancer: retrospective analysis of 129 patients. Radiother Oncol. 2008;87:367–375
  13. Myerson RJ, Kong F, Birnbaum EH, et al. Radiation therapy for epidermoid carcinoma of the anal canal, clinical and treatment factors associated with outcome. Radiother Oncol. 2001;61:15–22
  14. Ajani JA, Winter KA, Gunderson LL, Pedersen J, Benson AB, Thomas CR, et al. US intergroup anal carcinoma trial: tumor diameter predicts for colostomy. J Clin Oncol. 2009;27:1116–1121
  15. Das P, Bhatia S, Eng C, Ajani JA, Skibber JM, Rodriguez-Bigas MA, et al. Predictors and patterns of recurrence after definitive chemoradiation for anal cancer. Int J Radiat Oncol Biol Phys. 2007;68:794–800
  16. Constantinou EC, Daly W, Fung CY, et al. Time–dose considerations in the treatment of anal cancer. Int J Radiat Oncol Biol Phys. 1997;39:651–657[Oncol Invest 1994;2:152–6]
  17. Ferrigno R, Nakamura RA, Dos Santos Novaes PE, Pellizzon AC, Maia MA, Fogarolli RC, et al. Radiochemotherapy in the conservative treatment of anal canal carcinoma: retrospective analysis of results and radiation dose effectiveness. Int J Radiat Oncol Biol Phys. 2005;61:1136–1142
  18. Rich TA, Ajani JA, Morrison WH, Ota D, Levin B. Chemoradiation therapy for anal cancer: radiation plus continuous infusion of 5-fluorouracil with or without cisplatin. Radiother Oncol. 1993;27:209–215
  19. Deniaud-Alexandre E, Touboul E, Tiret E, et al. Epidermoid carcinomas of the anal canal treated with definitive radiation therapy in a series of 305 patients. Cancer Radiother. 2003;7:237–253
  20. John M, Pajak T, Flam M, et al. Dose escalation in chemoradiation for anal cancer: preliminary results of RTOG 92-08. Cancer J Sci Am. 1996;2:205–211
  21. John Gerard JP, Ayzac L, Hun D, et al. Treatment of anal canal carcinoma with high dose radiation therapy and concomitant fluorouracil-cisplatinum. Long-term results in 95 patients. Radiother Oncol. 1998;46:249–256
  22. Conroy T, Ducreux M, Lemanski C, et al. Treatment intensification by induction chemotherapy (ICT) and radiation dose escalation in locally advanced squamous cell anal canal carcinoma (LAAC): definitive analysis of the intergroup ACCORD 03 trial. J CO. 2009;27:4033;[Meeting Abstracts]
  23. Konski A, Garcia M, John M, et al. Evaluation of planned treatment breaks during radiation therapy for anal cancer: update of RTOG 92-08. Int J Radiat Oncol Biol Phys. 2008;72:114–118
  24. Weber DC, Kurtz JM, Allal AS. The impact of gap duration on local control in anal canal carcinomatreated by split-course radiotherapy and concomitant chemotherapy. Int J Radiat Oncol Biol Phys. 2001;50:675–680

PII: S0167-8140(10)00239-2

doi: 10.1016/j.radonc.2010.04.013

Radiotherapy & Oncology
Volume 95, Issue 3 , Pages 283-287 , June 2010