Radiotherapy & Oncology
Volume 95, Issue 3 , Pages 298-302 , June 2010

Tumour regression grading in patients with residual rectal cancer after preoperative chemoradiation

  • Krzysztof Bujko

      Affiliations

    • Departments of Radiotherapy, The Maria Sklodowska-Curie Memorial Cancer Centre, Warsaw, Poland
    • Corresponding Author InformationCorresponding author. Address: The Maria Sklodowska-Curie Memorial Cancer Centre, W.K. Roentgena 5, 02 781 Warsaw, Poland.
    • ,
  • Milena Kolodziejczyk

      Affiliations

    • Departments of Radiotherapy, The Maria Sklodowska-Curie Memorial Cancer Centre, Warsaw, Poland
    • ,
  • Anna Nasierowska-Guttmejer

      Affiliations

    • Department of Pathology, Clinical Hospital of Ministry of Internal Affairs and Administration, Warsaw, Poland
    • ,
  • Wojciech Michalski

      Affiliations

    • Clinical Trials and Biostatistics Unit, The Maria Sklodowska-Curie Memorial Cancer Centre, Warsaw, Poland
    • ,
  • Lucyna Kepka

      Affiliations

    • Departments of Radiotherapy, The Maria Sklodowska-Curie Memorial Cancer Centre, Warsaw, Poland
    • ,
  • Ewa Chmielik

      Affiliations

    • Department of Pathology, The Maria Sklodowska-Curie Memorial Cancer Centre, Gliwice, Poland
    • ,
  • Andrzej Wojnar

      Affiliations

    • Department of Pathology, Silesian Oncological Centre, Wroclaw, Poland
    • ,
  • Maciej Chwalinski

      Affiliations

    • Department of Colorectal Cancer, The Maria Sklodowska-Curie Memorial Cancer Centre, Warsaw, Poland
    • ,
  • on behalf of the Polish Colorectal Cancer Group

Received 20 December 2009 ,Revised 1 April 2010 ,Accepted 5 April 2010.

References 

  1. Capirci C, Valentini V, Cionini L, et al. Prognostic value of pathologic complete response after neoadjuvant therapy in locally advanced rectal cancer: long-term analysis of 566 ypCR patients. Int J Rad Oncol Biol Phys. 2008;72:99–107
  2. Rodel C, Martus P, Papadoupolos T, et al. Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer. J Clin Oncol. 2005;23:8688–8696
  3. Machiels JP, Aydin S, Bonny MA, Hammouch F, Sempoux C. What is the best way to predict disease-free survival after preoperative radiochemotherapy for rectal cancer patients: tumor regression grading, nodal status, or circumferential resection margin invasion?. J Clin Oncol. 2006;24:1319
  4. Vecchio FM, Valentini V, Minsky BD, et al. The relationship of pathologic tumor regression grade (TRG) and outcomes after preoperative therapy in rectal cancer. Int J Radiat Oncol Biol Phys. 2005;62:752–760
  5. Beddy D, Hyland JM, Winter DC, et al. A simplified tumor regression grade correlates with survival in locally advanced rectal carcinoma treated with neoadjuvant chemoradiotherapy. Ann Surg Oncol. 2008;15:3471–3477
  6. Losi L, Luppi G, Gavioli M, et al. Prognostic value of Dworak grade of regression (GR) in patients with rectal carcinoma treated with preoperative radiochemotherapy. Int J Colorectal Dis. 2006;1:645–651
  7. Suárez J, Vera R, Balén E, et al. Pathologic response assessed by Mandard grade is a better prognostic factor than down staging for disease-free survival after preoperative radiochemotherapy for advanced rectal cancer. Colorectal Dis. 2008;10:563–568
  8. Lindebjerg J, Spindler KL, Ploen J, Jakobsen A. The prognostic value of lymph node metastases and tumour regression grade in rectal cancer patients treated with long-course preoperative chemoradiotherapy. Colorectal Dis. 2009;11:264–269
  9. Ryan R, Gibbons D, Hyland JM, et al. Pathological response following long-course neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Histopathology. 2005;47:141–146
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  11. Shia J, Guillem JG, Moore HG, et al. Patterns of morphologic alteration in residual rectal carcinoma following preoperative chemoradiation and their association with long-term outcome. Am J Surg Pathol. 2004;28:215–223
  12. Bouzourene H, Bosman FT, Seelentag W, Matter M, Coucke P. Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy. Cancer. 2002;15:1121–1130
  13. Berho M, Oviedo M, Stone E, et al. The correlation between tumour regression grade and lymph node status after chemoradiation in rectal cancer. Colorectal Dis. 2009;11:254–258
  14. Berger C, de Muret A, Garaud P, et al. Preoperative radiotherapy (RT) for rectal cancer: predictive factors of tumor downstaging and residual tumor cell density (RTCD): prognostic implications. Int J Radiat Oncol Biol Phys. 1997;37:619–627
  15. Colon and rectum. In: AJCC cancer staging manual. 7th ed. <http://www.cancerstaging.net/> [accessed December 2009].
  16. Bujko K, Nowacki MP, Nasierowska-Guttmejer A, et al. Sphincter preservation following preoperative radiotherapy for rectal cancer: report of a randomised trial comparing short-term radiotherapy vs. conventionally fractionated radiochemotherapy. Radiother Oncol. 2004;72:15–24
  17. Bujko K, Nowacki MP, Nasierowska-Guttmejer A, Michalski W, Bebenek M, Kryj M. Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer. Br J Surg. 2006;93:1215–1223
  18. Marijnen CA, Nagtegaal ID, Klein Kranenbarg E, et al. No downstaging after short-term preoperative radiotherapy in rectal cancer patients. J Clin Oncol. 2001;19:1976–1984
  19. Glynne-Jones R, Anyamene N. Just how useful an endpoint is complete pathological response after neoadjuvant chemoradiation in rectal cancer?. Int J Radiat Oncol Biol Phys. 2006;66:319–320
  20. Bujko K, Nowacki MP, Nasierowska-Guttmejer A, et al. Prediction of mesorectal nodal metastases after chemoradiation for rectal cancer: results of a randomised trial: implication for subsequent local excision. Radiother Oncol. 2005;76:234–240

☆ Presented at European Multidisciplinary Colorectal Cancer Congress 2010, 28–29 March 2010, Nice, France.

PII: S0167-8140(10)00231-8

doi: 10.1016/j.radonc.2010.04.005

Radiotherapy & Oncology
Volume 95, Issue 3 , Pages 298-302 , June 2010

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