Radiotherapy & Oncology
Volume 96, Issue 2 , Pages 199-203 , August 2010

Breast radiotherapy as part of loco-regional treatments in stage IV breast cancer patients with oligometastatic disease

  • Céline Bourgier

      Affiliations

    • Department of Radiation Oncology, Institut Gustave Roussy, Villejuif, France
    • Corresponding Author InformationCorresponding author at: Département de Radiothérapie, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94 800 Villejuif, France.
    • ,
  • Wassim Khodari

      Affiliations

    • Department of Radiation Oncology, Institut Gustave Roussy, Villejuif, France
    • ,
  • Anne-Lise Vataire

      Affiliations

    • Biostatistics and Epidemiology Unit, Institut Gustave Roussy, Villejuif, France
    • ,
  • Eduardo Lima Pessoa

      Affiliations

    • Department of Radiation Oncology, Institut Gustave Roussy, Villejuif, France
    • ,
  • Ariane Dunant

      Affiliations

    • Biostatistics and Epidemiology Unit, Institut Gustave Roussy, Villejuif, France
    • ,
  • Suzette Delaloge

      Affiliations

    • Department of Medical Oncology, Institut Gustave Roussy, Villejuif, France
    • ,
  • Catherine Uzan

      Affiliations

    • Department of Breast Surgery, Institut Gustave Roussy, Villejuif, France
    • ,
  • Corinne Balleyguier

      Affiliations

    • Department of Radiology, Institut Gustave Roussy, Villejuif, France
    • ,
  • Marie-Christine Mathieu

      Affiliations

    • Department of Pathology, Institut Gustave Roussy, Villejuif, France
    • ,
  • Hugo Marsiglia

      Affiliations

    • Department of Radiation Oncology, Institut Gustave Roussy, Villejuif, France
    • University of Florence, Italy
    • ,
  • Rodrigo Arriagada

      Affiliations

    • Department of Radiation Oncology, Institut Gustave Roussy, Villejuif, France
    • Department of Oncology, Karolinska Institutet, Stockholm, Sweden

Received 18 August 2009 ,Revised 12 February 2010 ,Accepted 23 February 2010.

References 

  1. Rao R, Feng L, Kuerer HM, et al. Timing of surgical intervention for the intact primary in stage IV breast cancer patients. Ann Surg Oncol. 2008;15:1696–1702
  2. Blanchard DK, Shetty PB, Hilsenbeck SG, Elledge RM. Association of surgery with improved survival in stage IV breast cancer patients. Ann Surg. 2008;247:732–738
  3. Babiera GV, Rao R, Feng L, et al. Effect of primary tumor extirpation in breast cancer patients who present with stage IV disease and an intact primary tumor. Ann Surg Oncol. 2006;13:776–782
  4. Gnerlich J, Jeffe DB, Deshpande AD, Beers C, Zander C, Margenthaler JA. Surgical removal of the primary tumor increases overall survival in patients with metastatic breast cancer: analysis of the 1988–2003 SEER data. Ann Surg Oncol. 2007;14:2187–2194
  5. Muss HB, Case LD, Richards F, et al. Interrupted versus continuous chemotherapy in patients with metastatic breast cancer. The Piedmont Oncology Association. N Engl J Med. 1991;325:1342–1348
  6. Norton L. Metastatic breast cancer. Length and quality of life. N Engl J Med. 1991;325:1370–1371
  7. Andre F, Slimane K, Bachelot T, et al. Breast cancer with synchronous metastases: trends in survival during a 14-year period. J Clin Oncol. 2004;22:3302–3308
  8. Hortobagyi NG. Can we cure limited metastatic breast cancer?. J Clin Oncol. 2001;20:620–623
  9. Carmichael AR, Anderson ED, Chetty U, Dixon JM. Does local surgery have a role in the management of stage IV breast cancer?. Eur J Surg Oncol. 2003;29:17–19
  10. Khan SA, Stewart AK, Morrow M. Does aggressive local therapy improve survival in metastatic breast cancer?. Surgery. 2002;132:620–626discussion 626–7
  11. Le Scodan R, Stevens D, Brain E, et al. Breast cancer with synchronous metastases: survival impact of exclusive locoregional radiotherapy. J Clin Oncol. 2009;27:1375–1381
  12. Griffiths CT, Parker LM, Lee S, Finkler NJ. The effect of residual mass size on response to chemotherapy after surgical cytoreduction for advanced ovarian cancer: long-term results. Int J Gynecol Cancer. 2002;12:323–331
  13. Martin R, Paty P, Fong Y, et al. Simultaneous liver and colorectal resections are safe for synchronous colorectal liver metastasis. J Am Coll Surg. 2003;197:233–241discussion 241–32
  14. Rosen SA, Buell JF, Yoshida A, et al. Initial presentation with stage IV colorectal cancer: how aggressive should we be?. Arch Surg. 2000;135:530–534discussion 534–5
  15. Tanaka K, Shimada H, Matsuo K, et al. Outcome after simultaneous colorectal and hepatic resection for colorectal cancer with synchronous metastases. Surgery. 2004;136:650–659
  16. Schemper M, Smith TL. A note on quantifying follow-up in studies of failure time. Control Clin Trials. 1996;17:343–346
  17. Cox DR. Regression models and life tables (with discussion). J R Stat Soc [B]. 1972;34:187–220
  18. Bartsch R, Fromm S, Rudas M, et al. Intensified local treatment and systemic therapy significantly increase survival in patients with brain metastases from advanced breast cancer – a retrospective analysis. Radiother Oncol. 2006;80:313–317
  19. Goldie JH, Coldman AJ. A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate. Cancer Treat Rep. 1979;63:1727–1733
  20. Dauplat J, Le Bouedec G, Pomel C, Scherer C. Cytoreductive surgery for advanced stages of ovarian cancer. Semin Surg Oncol. 2000;19:42–48
  21. Cristofanilli M, Budd GT, Ellis MJ, et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med. 2004;351:781–791
  22. Overgaard M, Hansen PS, Overgaard J, et al. Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial. N Engl J Med. 1997;337:949–955
  23. Overgaard M, Jensen MB, Overgaard J, et al. Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial. Lancet. 1999;353:1641–1648
  24. Ragaz J, Jackson SM, Le N, et al. Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer. N Engl J Med. 1997;337:956–962
  25. Ragaz J, Olivotto IA, Spinelli JJ, et al. Locoregional radiation therapy in patients with high-risk breast cancer receiving adjuvant chemotherapy: 20-year results of the British Columbia randomized trial. J Natl Cancer Inst. 2005;97:116–126
  26. Kyndi M, Sorensen FB, Knudsen H, Overgaard M, Nielsen HM, Overgaard J. Estrogen receptor, progesterone receptor, HER-2, and response to postmastectomy radiotherapy in high-risk breast cancer: the Danish Breast Cancer Cooperative Group. J Clin Oncol. 2008;26:1419–1426
  27. Kyndi M, Overgaard M, Nielsen HM, Sorensen FB, Knudsen H, Overgaard J. High local recurrence risk is not associated with large survival reduction after postmastectomy radiotherapy in high-risk breast cancer: a subgroup analysis of DBCG 82 b&c. Radiother Oncol. 2009;90:74–79
  28. Overgaard M, Nielsen HM, Overgaard J. Is the benefit of postmastectomy irradiation limited to patients with four or more positive nodes, as recommended in international consensus reports? A subgroup analysis of the DBCG 82 b&c randomized trials. Radiother Oncol. 2007;82:247–253
  29. Arriagada R, Mouriesse H, Sarrazin D, Clark RM, Deboer G. Radiotherapy alone in breast cancer. I. Analysis of tumor parameters, tumor dose and local control: the experience of the Gustave-Roussy Institute and the Princess Margaret Hospital. Int J Radiat Oncol Biol Phys. 1985;11:1751–1757
  30. Courdi A, Ortholan C, Hannoun-Levi JM, et al. Long-term results of hypofractionated radiotherapy and hormonal therapy without surgery for breast cancer in elderly patients. Radiother Oncol. 2006;79:156–161
  31. Fourquet A, Campana F, Mosseri V, et al. Iridium-192 versus cobalt-60 boost in 3–7cm breast cancer treated by irradiation alone: final results of a randomized trial. Radiother Oncol. 1995;34:114–120
  32. Bentzen SM, Agrawal RK, Aird EG, et al. The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial. Lancet Oncol. 2008;9:331–341
  33. Bentzen SM, Agrawal RK, Aird EG, et al. The UK Standardisation of Breast Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial. Lancet. 2008;371:1098–1107
  34. Whelan T, MacKenzie R, Julian J, et al. Randomized trial of breast irradiation schedules after lumpectomy for women with lymph node-negative breast cancer. J Natl Cancer Inst. 2002;94:1143–1150
  35. Bafford AC, Burstein HJ, Barkley CR, et al. Breast surgery in stage IV breast cancer: impact of staging, patient selection on overall survival. Breast Cancer Res Treat. 2009;115:7–12
  36. Pocard M, Pouillart P, Asselain B, Falcou MC, Salmon RJ. Hepatic resection for breast cancer metastases: results and prognosis (65 cases). Ann Chir. 2001;126:413–420
  37. Vlastos G, Smith DL, Singletary SE, et al. Long-term survival after an aggressive surgical approach in patients with breast cancer hepatic metastases. Ann Surg Oncol. 2004;11:869–874
  38. Rivera E, Holmes FA, Buzdar AU, et al. Fluorouracil, doxorubicin, and cyclophosphamide followed by tamoxifen as adjuvant treatment for patients with stage IV breast cancer with no evidence of disease. Breast J. 2002;8:2–9

☆ Meeting presentation: 2008 ASCO Annual Meeting. J Clin Oncol 2008;26 (May 20 Suppl; Abstract No. 1085).

PII: S0167-8140(10)00158-1

doi: 10.1016/j.radonc.2010.02.028

Radiotherapy & Oncology
Volume 96, Issue 2 , Pages 199-203 , August 2010

Article Tools