Long-term experience with transrectal and transperineal implantations of fiducial gold markers in the prostate for position verification in external beam radiotherapy; feasibility, toxicity and quality of life

Moman, Maaike R.; van der Heide, Uulke A.; Kotte, Alexis N.T.J.; van Moorselaar, R. Jeroen A.; Bol, Gijsbert H.; Franken, Stefan P.G.; van Vulpen, Marco

doi:10.1016/j.radonc.2010.02.027

« Previous Next »Radiotherapy & Oncology
Volume 96, Issue 1 , Pages 38-42, July 2010

Long-term experience with transrectal and transperineal implantations of fiducial gold markers in the prostate for position verification in external beam radiotherapy; feasibility, toxicity and quality of life

Maaike R. Moman
- Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
- Corresponding author. Address: Department of Radiation Oncology, Q00.118, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
Uulke A. van der Heide
- Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
Alexis N.T.J. Kotte
- Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
R. Jeroen A. van Moorselaar
- Department of Urology, VU Medical Center, Amsterdam, The Netherlands
Gijsbert H. Bol
- Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
Stefan P.G. Franken
- Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
Marco van Vulpen
- Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands

Received 8 April 2009; received in revised form 22 February 2010; accepted 23 February 2010. published online 24 March 2010.

Abstract

Background and purpose

This study presents an overview of the experience with transrectal and transperineal implantations of fiducial markers for position verification in prostate radiotherapy, regarding the practical feasibility, procedure-related toxicity and influence on quality of life (QoL).

Material and methods

Since 2001, 914 patients scheduled for intensity-modulated radiotherapy (IMRT) have received gold markers in the prostate. The incidence of severe toxicity, defined by the CTCAE v3.0, was evaluated retrospectively. The influence on QoL was measured prospectively in 36 patients using a combination of three validated questionnaires: the Rand-36, the EORTC QLQ-C30(+3) and the prostate cancer-specific EORTC QLQ-PR25. Next, the incidence of marker migration was assessed.

Results

From 2001 to 2005, 402 patients received markers via the transrectal route. Two of these patients developed urosepsis (grade 3 toxicity). Since 2005, 512 patients received markers via the transperineal route. No grade 3 or 4 toxicity occurred in this group. No significant and clinically relevant differences were found in QoL between pre- and post-implant measures. In 5 patients marker migration led to discontinuation of the marker-based IMRT.

Conclusions

Clinical use of transperineal-implanted fiducial gold markers for position verification in external beam radiotherapy for prostate cancer is a feasible and safe procedure without influencing patients’ QoL.

Keywords: Prostate cancer, Radiotherapy, Position verification, Fiducial markers