Radiotherapy & Oncology
Volume 95, Issue 2 , Pages 135-141, May 2010

A systematic methodology review of phase I radiation dose escalation trials

  • Madelon Pijls-Johannesma

      Affiliations

    • Department of Radiation Oncology (MAASTRO), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, The Netherlands
    • Corresponding Author InformationCorresponding author. Address: Maastro Clinic, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.
    • These authors equally contributed to this work.
  • ,
  • Ghislaine van Mastrigt

      Affiliations

    • Department of Radiation Oncology (MAASTRO), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, The Netherlands
    • These authors equally contributed to this work.
  • ,
  • Steve M. Hahn

      Affiliations

    • Department of Radiotherapy, Hospital of the University of Pennsylvania, Philadelphia, USA
  • ,
  • Dirk De Ruysscher

      Affiliations

    • Department of Radiation Oncology (MAASTRO), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, The Netherlands
  • ,
  • Brigitta G. Baumert

      Affiliations

    • Department of Radiation Oncology (MAASTRO), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, The Netherlands
  • ,
  • Guido Lammering

      Affiliations

    • Department of Radiation Oncology (MAASTRO), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, The Netherlands
  • ,
  • Jeroen Buijsen

      Affiliations

    • Department of Radiation Oncology (MAASTRO), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, The Netherlands
  • ,
  • Soren M. Bentzen

      Affiliations

    • Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, WI, USA
  • ,
  • Yolande Lievens

      Affiliations

    • Department of Radiation Oncology, Universitaire Ziekenhuizen Leuven, Leuven, Belgium
  • ,
  • Andrew Kramar

      Affiliations

    • CRLC Val d’Aurelle – Paul Lamarque, Unité de Biostatistique, Montpellier, France
  • ,
  • Philippe Lambin

      Affiliations

    • Department of Radiation Oncology (MAASTRO), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, The Netherlands

Received 17 September 2009; accepted 8 February 2010. published online 25 March 2010.

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PII: S0167-8140(10)00086-1

doi:10.1016/j.radonc.2010.02.009

Radiotherapy & Oncology
Volume 95, Issue 2 , Pages 135-141, May 2010