Radiotherapy & Oncology
Volume 94, Issue 3 , Pages 307-312 , March 2010

Limited benefit of inversely optimised intensity modulation in breast conserving radiotherapy with simultaneously integrated boost

  • Hans Paul van der Laan

      Affiliations

    • Department of Radiation Oncologyand
    • Corresponding Author InformationCorresponding author. Address: Department of Radiation Oncology, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands.
    • ,
  • Wil V. Dolsma

      Affiliations

    • Department of Radiation Oncologyand
    • ,
  • Cornelis Schilstra

      Affiliations

    • Department of Radiation Oncologyand
    • ,
  • Erik W. Korevaar

      Affiliations

    • Department of Radiation Oncologyand
    • ,
  • Geertruida H. de Bock

      Affiliations

    • Department of Epidemiology, University Medical Center Groningen, University of Groningen, The Netherlands
    • ,
  • John H. Maduro

      Affiliations

    • Department of Radiation Oncologyand
    • ,
  • Johannes A. Langendijk

      Affiliations

    • Department of Radiation Oncologyand

Received 7 September 2009 ,Revised 25 January 2010 ,Accepted 28 January 2010.

References 

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  2. Fisher B, Anderson S, Bryant J, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347:1233–1241
  3. Bartelink H, Horiot JC, Poortmans PM, et al. Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-year results of the randomized boost versus no boost EORTC 22881-10882 trial. J Clin Oncol. 2007;25:3259–3265
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  5. Guerrero M, Li XA, Earl MA, et al. Simultaneous integrated boost for breast cancer using IMRT: a radiobiological and treatment planning study. Int J Radiat Oncol Biol Phys. 2004;59:1513–1522
  6. van der Laan HP, Dolsma WV, Maduro JH, et al. Three-dimensional conformal simultaneously integrated boost technique for breast-conserving radiotherapy. Int J Radiat Oncol Biol Phys. 2007;68:1018–1023
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  8. Ahunbay EE, Chen GP, Thatcher S, et al. Direct aperture optimization-based intensity-modulated radiotherapy for whole breast irradiation. Int J Radiat Oncol Biol Phys. 2007;67:1248–1258
  9. Hurkmans CW, Meijer GJ, van Vliet-Vroegindeweij C, et al. High-dose simultaneously integrated breast boost using intensity-modulated radiotherapy and inverse optimization. Int J Radiat Oncol Biol Phys. 2006;66:923–930
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  11. Van den Steen D, Hulstaert F, Camberlin C. Intensiteitsgemoduleerde Radiotherapie (IMRT), Health Technology Assessment (HTA), KCE reports 62A (D2007/10.273/32). Brussel: Federaal Kenniscentrum voor de Gezondheidszorg (KCE); 2007.
  12. Seppenwoolde Y, Lebesque JV, de Jaeger K, et al. Comparing different NTCP models that predict the incidence of radiation pneumonitis. Normal tissue complication probability. Int J Radiat Oncol Biol Phys. 2003;55:724–735
  13. Semenenko VA, Li XA. Lyman–Kutcher–Burman NTCP model parameters for radiation pneumonitis and xerostomia based on combined analysis of published clinical data. Phys Med Biol. 2008;53:737–755
  14. Gagliardi G, Lax I, Ottolenghi A, et al. Long-term cardiac mortality after radiotherapy of breast cancer – application of the relative seriality model. Br J Radiol. 1996;69:839–846
  15. Alexander MA, Brooks WA, Blake SW. Normal tissue complication probability modelling of tissue fibrosis following breast radiotherapy. Phys Med Biol. 2007;52:1831–1843
  16. Remouchamps VM, Vicini FA, Sharpe MB, et al. Significant reductions in heart and lung doses using deep inspiration breath hold with active breathing control and intensity-modulated radiation therapy for patients treated with locoregional breast irradiation. Int J Radiat Oncol Biol Phys. 2003;55:392–406
  17. van der Laan HP, Hurkmans CW, Kuten A, et al. Current technological clinical practise in breast radiotherapy; results of a survey in EORTC-Radiation Oncology Group affiliated institutions. Radiother Oncol. 2010;94:280–285

☆ Presented at the 27th biennial meeting of the European Society for Therapeutic Radiology and Oncology (ESTRO), September 14–18, 2008, Göteborg, Sweden.

PII: S0167-8140(10)00076-9

doi: 10.1016/j.radonc.2010.01.024

Radiotherapy & Oncology
Volume 94, Issue 3 , Pages 307-312 , March 2010

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