Radiotherapy & Oncology
Volume 94, Issue 3 , Pages 274-279 , March 2010

Accelerated partial-breast irradiation using high-dose-rate interstitial brachytherapy: 12-year update of a prospective clinical study

  • Csaba Polgár

      Affiliations

    • Department of Radiotherapy, National Institute of Oncology, Budapest, Hungary
    • Corresponding Author InformationCorresponding author. Address: Department of Radiotherapy, National Institute of Oncology, Ráth György u. 7-9, Budapest H-1122, Hungary.
    • ,
  • Tibor Major

      Affiliations

    • Department of Radiotherapy, National Institute of Oncology, Budapest, Hungary
    • ,
  • János Fodor

      Affiliations

    • Department of Radiotherapy, National Institute of Oncology, Budapest, Hungary
    • ,
  • Zoltán Sulyok

      Affiliations

    • Department of General and Thoracic Surgery, National Institute of Oncology, Budapest, Hungary
    • ,
  • András Somogyi

      Affiliations

    • Department of Radiotherapy, National Institute of Oncology, Budapest, Hungary
    • ,
  • Katalin Lövey

      Affiliations

    • Department of Radiotherapy, National Institute of Oncology, Budapest, Hungary
    • ,
  • György Németh

      Affiliations

    • Department of Radiotherapy, National Institute of Oncology, Budapest, Hungary
    • ,
  • Miklós Kásler

      Affiliations

    • National Institute of Oncology, Budapest, Hungary

Received 12 September 2009 ,Revised 26 January 2010 ,Accepted 29 January 2010.

References 

  1. Fisher B, Anderson S, Bryant J, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347:1233–1241
  2. Veronesi U, Cascinelli N, Mariani L, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med. 2002;347:1227–1232
  3. Antonucci JV, Wallace M, Goldstein NS, et al. Differences in patterns of failure in patients treated with accelerated partial breast irradiation versus whole-breast irradiation: a matched-pair analysis with 10-year follow-up. Int J Radiat Oncol Biol Phys. 2009;74:447–452
  4. Fentiman IS, Deshmane V, Tong D, et al. Caesium137 implant as sole radiation therapy for operable breast cancer: a phase II trial. Radiother Oncol. 2004;71:281–285
  5. Johansson B, Karlsson L, Liljegren G, et al. Pulsed dose rate brachytherapy as the sole adjuvant radiotherapy after breast-conserving surgery of T1–T2 breast cancer: first long time results from a clinical study. Radiother Oncol. 2009;90:30–35
  6. Magee B, Swindell R, Harris M, et al. Prognostic factors for breast recurrence after conservative breast surgery and radiotherapy: results of a randomised trial. Radiother Oncol. 1996;39:223–227
  7. Niehoff P, Polgár C, Ostertag H, et al. Clinical experience with the MammoSite® Radiation Therapy System for intracavitary brachytherapy of breast cancer – results from an international phase II trial. Radiother Oncol. 2006;79:316–320
  8. Ott OJ, Hildebrandt G, Pötter R, et al. Accelerated partial breast irradiation with multi-catheter brachytherapy: local control, side effects and cosmetic outcome for 274 patients. Results of the German–Austrian multi-centre trial. Radiother Oncol. 2007;82:281–286
  9. Slampa P, Ruzickova J, Ondrova B, et al. Sole conformal perioperative interstitial brachytherapy of early stage breast carcinoma using high-dose-rate afterloading: longer-term results and toxicity. Rep Pract Oncol Radiother. 2008;13:63–68
  10. Polgár C, Strnad V, Major T. Brachytherapy for partial breast irradiation: the European experience. Semin Radiat Oncol. 2005;15:116–122
  11. Vicini FA, Arthur DW. Breast brachytherapy: North American experience. Semin Radiat Oncol. 2005;15:108–115
  12. Polgár C, Major T. Current status and perspectives of brachytherapy for breast cancer. Int J Clin Oncol. 2009;14:7–24
  13. Polgár C, Major T, Fodor J, et al. HDR brachytherapy alone versus whole breast radiotherapy with or without tumor bed boost after breast conserving surgery: seven-year results of a comparative study. Int J Radiat Oncol Biol Phys. 2004;60:1173–1181
  14. Polgár C, Major T, Somogyi A, et al. Sole brachytherapy of the tumour bed after breast conserving surgery: a new radiotherapeutic strategy for patients at low risk of local relapse. Neoplasma. 1999;46:182–189
  15. Polgár C, Sulyok Z, Fodor J, et al. Sole brachytherapy of the tumor bed after conservative surgery for T1 breast cancer: five-year results of a phase I–II study and initial findings of a randomized phase III trial. J Surg Oncol. 2002;80:121–128
  16. Harris J, Levine M, Svensson G, et al. Analysis of cosmetic results following primary radiation therapy for stage I and II carcinoma of the breast. Int J Radiat Oncol Biol Phys. 1979;5:257–261
  17. Cox JD, Stetz J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys. 1995;31:1341–1346
  18. Lövey K, Fodor J, Major T, et al. Fat necrosis after partial-breast irradiation with brachytherapy or electron irradiation versus standard whole-breast radiotherapy – 4-year results of a randomized trial. Int J Radiat Oncol Biol Phys. 2007;69:724–731
  19. Kaplan EL, Meier P. Non-parametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457–481
  20. Cox DR. Regression models and life tables. J R Stat Soc. 1972;34:187–220
  21. Aristei C, Tarducci R, Palumbo I, et al. Computed tomography for excision cavity localization and 3D-treatment planning in partial breast irradiation with high-dose-rate interstitial brachytherapy. Radiother Oncol. 2009;90:43–47
  22. Arthur DW, Winter K, Kuske RR, et al. A phase II trial of brachytherapy alone after lumpectomy for select breast cancer: tumor control and survival outcomes of RTOG 95–17. Int J Radiat Oncol Biol Phys. 2008;72:467–473
  23. Belkacémi Y, Chauvet MP, Giard S, et al. Partial breast irradiation as sole therapy for low risk breast carcinoma: early toxicity, cosmesis and quality of life results of a MammoSite brachytherapy phase II study. Radiother Oncol. 2009;90:23–29
  24. Benitez PR, Keisch ME, Vicini F, et al. Five-year results: the initial clinical trial of Mammosite balloon brachytherapy for partial breast irradiation in early-stage breast cancer. Am J Surg. 2007;194:456–462
  25. Fijuth J. Brachytherapy in breast cancer. J Contemp Brachyther. 2009;1:117–120
  26. King TA, Bolton JS, Kuske RR, et al. Long-term results of wide-field brachytherapy as the sole method of radiation therapy after segmental mastectomy for Tis, 1, 2 breast cancer. Am J Surg. 2000;180:299–304
  27. Major T, Fröhlich G, Lövey K, et al. Dosimetric experience with accelerated partial breast irradiation using image-guided interstitial brachytherapy. Radiother Oncol. 2009;90:48–55
  28. Mannino M, Yarnold J. Accelerated partial breast irradiation trials: diversity in rationale and design. Radiother Oncol. 2009;91:16–22
  29. Moon SH, Shin KH, Kim TH, et al. Dosimetric comparison of four different external beam partial breast irradiation techniques: three-dimensional conformal radiotherapy, intensity-modulated radiotherapy, helical tomotherapy, and proton beam therapy. Radiother Oncol. 2009;90:66–73
  30. Offersen BV, Overgaard M, Kroman N, et al. Accelerated partial breast irradiation as part of breast conserving therapy of early breast carcinoma: a systematic review. Radiother Oncol. 2009;90:1–13
  31. Polgár C, Fodor J, Major T, et al. Breast-conserving treatment with partial or whole breast irradiation for low-risk invasive breast carcinoma – 5-year results of a randomized trial. Int J Radiat Oncol Biol Phys. 2007;69:694–702
  32. Polgár C, Major T, Lövey K, et al. Hungarian experience on partial breast irradiation versus whole breast irradiation: 12-year results of a phase II trial and updated results of a randomized study. Brachytherapy. 2008;7:91–92[Abstract]
  33. Samuel LM, Dewar JA, Preece PE, et al. A pilot study of radical radiotherapy using a perioperative implant following wide local excision for carcinoma of the breast. Breast. 1999;8:95–97
  34. Scanderbeg DJ, Yashar C, Rice R, et al. Clinical implementation of a new HDR brachytherapy device for partial breast irradiation. Radiother Oncol. 2009;90:36–42
  35. Strauss JB, Dickler A. Accelerated partial breast irradiation utilizing balloon brachytherapy techniques. Radiother Oncol. 2009;91:157–165
  36. Strnad V, Ott OJ, Hildebrandt G, et al. Partial breast irradiation using multicatheter interstitial brachytherapy for early breast cancer: results of the German–Austrian multicenter Phase II trial. Brachytherapy. 2009;8:107;[Abstract]
  37. Thomas CW, Nichol AM, Park JE, et al. An anthropomorphic phantom study of visualisation of surgical clips for partial breast irradiation (PBI) setup verification. Radiother Oncol. 2009;90:56–59
  38. Van Limbergen E. Accelerated partial breast irradiation with intracavitary balloon brachytherapy may be not as simple as it was supposed to be. Radiother Oncol. 2009;91:147–149
  39. Vicini FA, Antonucci V, Wallace M, et al. Long-term efficacy and patterns of failure after accelerated partial breast irradiation: a molecular assay-based clonality evaluation. Int J Radiat Oncol Biol Phys. 2007;68:341–346

PII: S0167-8140(10)00071-X

doi: 10.1016/j.radonc.2010.01.019

Radiotherapy & Oncology
Volume 94, Issue 3 , Pages 274-279 , March 2010

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