Radiotherapy & Oncology
Volume 94, Issue 2 , Pages 156-160 , February 2010

Tumor perfusion increases during hypofractionated short-course radiotherapy in rectal cancer: Sequential perfusion-CT findings

  • Marco H.M. Janssen

      Affiliations

    • Department of Radiation Oncology (MAASTRO), Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands
    • Corresponding Author InformationCorresponding author. Address: Department of Radiation Oncology (MAASTRO), Maastricht University Medical Center (MUMC+), GROW-School for Oncology and Developmental Biology, Dr. Tanslaan 12, 6201 BN Maastricht, Box 1588, Maastricht, The Netherlands.
    • ,
  • Hugo J.W.L. Aerts

      Affiliations

    • Department of Radiation Oncology (MAASTRO), Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands
    • ,
  • Roel G.J. Kierkels

      Affiliations

    • Department of Radiation Oncology (MAASTRO), Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands
    • Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Walter H. Backes

      Affiliations

    • Department of Radiology, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands
    • ,
  • Michel C. Öllers

      Affiliations

    • Department of Radiation Oncology (MAASTRO), Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands
    • ,
  • Jeroen Buijsen

      Affiliations

    • Department of Radiation Oncology (MAASTRO), Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands
    • ,
  • Philippe Lambin

      Affiliations

    • Department of Radiation Oncology (MAASTRO), Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands
    • These authors contributed equally to this paper.
    • ,
  • Guido Lammering

      Affiliations

    • Department of Radiation Oncology (MAASTRO), Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands
    • These authors contributed equally to this paper.

Received 16 October 2009 ,Revised 13 December 2009 ,Accepted 20 December 2009.

References 

  1. Frykholm G, Glimelius B, Pahlman L. Preoperative irradiation with and without chemotherapy (MFL) in the treatment of primarily non-resectable adenocarcinoma of the rectum. Results from two consecutive studies. Eur J Cancer Clin Oncol. 1989;25:1535–1541
  2. Sauer R, Becker H, Hohenberger W, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004;351:1731–1740
  3. Sebag-Montefiore D. Developments in the use of chemoradiotherapy in rectal cancer. Colorectal Dis. 2006;8:14–17
  4. Improved survival with preoperative radiotherapy in resectable rectal cancer. Swedish rectal cancer trial. N Engl J Med 1997; 336: 980–987.
  5. Kapiteijn E, Marijnen CA, Nagtegaal ID, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med. 2001;345:638–646
  6. Peeters KC, Marijnen CA, Nagtegaal ID, et al. The TME trial after a median follow-up of 6 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma. Ann Surg. 2007;246:693–701
  7. Miles KA. Perfusion CT for the assessment of tumour vascularity: which protocol?. Br J Radiol. 2003;76:S36–S42
  8. Goh V, Padhani AR, Rasheed S. Functional imaging of colorectal cancer angiogenesis. Lancet Oncol. 2007;8:245–255
  9. Sahani DV, Kalva SP, Hamberg LM, et al. Assessing tumor perfusion and treatment response in rectal cancer with multisection CT: initial observations. Radiology. 2005;234:785–792
  10. Bellomi M, Petralia G, Sonzogni A, Zampino MG, Rocca A. CT perfusion for the monitoring of neoadjuvant chemotherapy and radiation therapy in rectal carcinoma: initial experience. Radiology. 2007;244:486–493
  11. Park MS, Klotz E, Kim MJ, et al. Perfusion CT: noninvasive surrogate marker for stratification of pancreatic cancer response to concurrent chemo- and radiation therapy. Radiology. 2009;250:110–117
  12. Wang J, Wu N, Cham MD, Song Y. Tumor response in patients with advanced non-small cell lung cancer: perfusion CT evaluation of chemotherapy and radiation therapy. AJR Am J Roentgenol. 2009;193:1090–1096
  13. Harvey C, Dooher A, Morgan J, Blomley M, Dawson P. Imaging of tumour therapy responses by dynamic CT. Eur J Radiol. 1999;30:221–226
  14. Tofts PS, Brix G, Buckley DL, et al. Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging. 1999;10:223–232
  15. Aerts HJ, van Riel NA, Backes WH. System identification theory in pharmacokinetic modeling of dynamic contrast-enhanced MRI: influence of contrast injection. Magn Reson Med. 2008;59:1111–1119
  16. Zima A, Carlos R, Gandhi D, Case I, Teknos T, Mukherji SK. Can pretreatment CT perfusion predict response of advanced squamous cell carcinoma of the upper aerodigestive tract treated with induction chemotherapy?. AJNR Am J Neuroradiol. 2007;28:328–334
  17. Hermans R, Lambin P, Van der Goten A, et al. Tumoural perfusion as measured by dynamic computed tomography in head and neck carcinoma. Radiother Oncol. 1999;53:105–111
  18. Hermans R, Van den Bogaert W. Outcome prediction after surgery and chemoradiation of head-and-neck squamous cell carcinoma (HNSCC), using baseline perfusion computed tomography (CT) microcirculatory parameters vs. tumor volume. Int J Radiat Oncol Biol Phys. 2009;74:1307;[author reply 1307]
  19. Daisne JF, Sibomana M, Bol A, Doumont T, Lonneux M, Gregoire V. Tri-dimensional automatic segmentation of PET volumes based on measured source-to-background ratios: influence of reconstruction algorithms. Radiother Oncol. 2003;69:247–250
  20. Ollers M, Bosmans G, van Baardwijk A, et al. The integration of PET-CT scans from different hospitals into radiotherapy treatment planning. Radiother Oncol. 2008;87:142–146
  21. Harrer JU, Parker GJ, Haroon HA, et al. Comparative study of methods for determining vascular permeability and blood volume in human gliomas. J Magn Reson Imaging. 2004;20:748–757
  22. Jackson A, Jayson GC, Li KL, et al. Reproducibility of quantitative dynamic contrast-enhanced MRI in newly presenting glioma. Br J Radiol. 2003;76:153–162
  23. Walker-Samuel S, Leach MO, Collins DJ. Reference tissue quantification of DCE-MRI data without a contrast agent calibration. Phys Med Biol. 2007;52:589–601
  24. Goh V, Halligan S, Hugill JA, Gartner L, Bartram CI. Quantitative colorectal cancer perfusion measurement using dynamic contrast-enhanced multidetector-row computed tomography: effect of acquisition time and implications for protocols. J Comput Assist Tomogr. 2005;29:59–63
  25. Henderson E, Rutt BK, Lee TY. Temporal sampling requirements for the tracer kinetics modeling of breast disease. Magn Reson Imaging. 1998;16:1057–1073
  26. Kierkels RG, Backes WH, Janssen MH, et al. Comparison between perfusion computed tomography and dynamic contrast-enhanced magnetic resonance imaging in rectal cancer. Int J Radiat Oncol Biol Phys. 2009;
  27. Goh V, Halligan S, Gartner L, Bassett P, Bartram CI. Quantitative colorectal cancer perfusion measurement by multidetector-row CT: does greater tumour coverage improve measurement reproducibility?. Br J Radiol. 2006;79:578–583

PII: S0167-8140(09)00671-9

doi: 10.1016/j.radonc.2009.12.013

Radiotherapy & Oncology
Volume 94, Issue 2 , Pages 156-160 , February 2010

Article Tools

* Image Usage & Resolution