Radiotherapy & Oncology
Volume 94, Issue 1 , Pages 67-70, January 2010

Re-irradiation of metastatic spinal cord compression: A feasibility study by volumetric-modulated arc radiotherapy for in-field recurrence creating a dosimetric hole on the central canal

  • Pietro Mancosu

      Affiliations

    • IRCCS Istituto Clinico Humanitas, Radiation Oncology, Rozzano, Italy
    • Corresponding Author InformationCorresponding author. Address: IRCCS Istituto Clinico Humanitas, Radiation Oncology, Via Manzoni 56, 20098 Rozzano, Italy.
    • ,
  • Piera Navarria

      Affiliations

    • IRCCS Istituto Clinico Humanitas, Radiation Oncology, Rozzano, Italy
    • ,
  • Mario Bignardi

      Affiliations

    • IRCCS Istituto Clinico Humanitas, Radiation Oncology, Rozzano, Italy
    • ,
  • Luca Cozzi

      Affiliations

    • Oncology Institute of Southern Switzerland, Medical Physics Unit, Bellinzona, Switzerland
    • ,
  • Antonella Fogliata

      Affiliations

    • Oncology Institute of Southern Switzerland, Medical Physics Unit, Bellinzona, Switzerland
    • ,
  • Paola Lattuada

      Affiliations

    • IRCCS Istituto Clinico Humanitas, Radiation Oncology, Rozzano, Italy
    • ,
  • Armando Santoro

      Affiliations

    • IRCCS Istituto Clinico Humanitas, Medical Oncology, Rozzano, Italy
    • ,
  • Gaetano Urso

      Affiliations

    • IRCCS Istituto Clinico Humanitas, Radiation Oncology, Rozzano, Italy
    • ,
  • Sabrina Vigorito

      Affiliations

    • IRCCS Istituto Clinico Humanitas, Radiation Oncology, Rozzano, Italy
    • ,
  • Marta Scorsetti

      Affiliations

    • IRCCS Istituto Clinico Humanitas, Radiation Oncology, Rozzano, Italy

Received 3 July 2009; received in revised form 13 November 2009; accepted 29 November 2009. published online 21 December 2009.

Abstract 

When local recurrences arise within an irradiated region involving metastatic spinal cord compression, the dose limit to the spinal cord reduces the chance to re-treat the patient by 3D-conformational RT technique. The possibility of using volumetric modulated arc RT by RapidArc was evaluated for dose sparing at spinal cord level and preserving target coverage. A clinically satisfactory PTV coverage and dose sparing to the spinal cord were obtained. An upcoming trial on patients will provide clinical outcomes.

Keywords: RapidArc, Metastatic spinal cord compression—MSCC, Re-irradiation, Radiotherapy, Volumetric modulated arc therapy

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PII: S0167-8140(09)00649-5

doi:10.1016/j.radonc.2009.11.010

Radiotherapy & Oncology
Volume 94, Issue 1 , Pages 67-70, January 2010

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