Radiotherapy & Oncology
Volume 94, Issue 1 , Pages 36-41 , January 2010

A prospective observational trial on emesis in radiotherapy: Analysis of 1020 patients recruited in 45 Italian radiation oncology centres

  • Ernesto Maranzano

      Affiliations

    • Radiotherapy Centre, “S. Maria” Hospital, Terni, Italy
    • Corresponding Author InformationCorresponding author. Address: S.C. Radioterapia Oncologica, Azienda Ospedaliera “S. Maria”, Via T. di Joannuccio, 1, O5100 Terni, Italy.
    • ,
  • Verena De Angelis

      Affiliations

    • Hospice, Perugia, Italy
    • ,
  • Stefano Pergolizzi

      Affiliations

    • Radiotherapy Centre, “S. Vincenzo” Hospital, Taormina (ME), Italy
    • ,
  • Marco Lupattelli

      Affiliations

    • Radiotherapy Centre, University Hospital, Perugia, Italy
    • ,
  • Paolo Frata

      Affiliations

    • “Istituto del Radio O. Alberti”, University Hospital, Brescia, Italy
    • ,
  • Stefano Spagnesi

      Affiliations

    • Radiotherapy Centre, “Santa Chiara” University Hospital, Pisa, Italy
    • ,
  • Maria Luisa Frisio

      Affiliations

    • Radiotherapy Centre, Oncologic Institute of Veneto – I.R.C.C.S., Padova, Italy
    • ,
  • Giovanni Mandoliti

      Affiliations

    • Radiotherapy Centre, “S. Maria della Misericordia” Hospital, Rovigo, Italy
    • ,
  • Giuseppe Malinverni

      Affiliations

    • Radiotherapy Centre, I.R.C.C., Candiolo (TO), Italy
    • ,
  • Fabio Trippa

      Affiliations

    • Radiotherapy Centre, “S. Maria” Hospital, Terni, Italy
    • ,
  • Letizia Fabbietti

      Affiliations

    • Radiotherapy Centre, “Umberto I” University Hospital, Ancona, Italy
    • ,
  • Salvatore Parisi

      Affiliations

    • Radiotherapy Centre, I.R.C.C.S., “Casa Sollievo della Sofferenza” Hospital, San Giovanni Rotondo (FG), Italy
    • ,
  • Annamaria Di Palma

      Affiliations

    • Radiotherapy Centre, “S. Maria” Hospital, Terni, Italy
    • ,
  • Pietro De Vecchi

      Affiliations

    • Radiotherapy Centre, “San Matteo” Foundation, Pavia, Italy
    • ,
  • Costantino De Renzis

      Affiliations

    • Radiotherapy Centre, “G. Martino” University Hospital, Messina, Italy
    • ,
  • Celestino Giorgetti

      Affiliations

    • Radiotherapy Centre, Hospital, Macerata, Italy
    • ,
  • Tiziano Bergami

      Affiliations

    • Radiotherapy Centre, “C. e G. Mazzoni” Hospital, Ascoli Piceno, Italy
    • ,
  • Roberto Orecchia

      Affiliations

    • Radiotherapy Centre, IEO-European Institut of Oncology, Milano, Italy
    • ,
  • Maurizio Portaluri

      Affiliations

    • Radiotherapy Centre, “A. Perrino” Hospital, Brindisi, Italy
    • ,
  • Marco Signor

      Affiliations

    • Radiotherapy Centre, “S. Maria della Misericordia” University Hospital, Udine, Italy
    • ,
  • Davide Di Gennaro

      Affiliations

    • Radiotherapy Centre, “S. Giovanni di Dio e Ruggi D’Aragona” University Hospital, Salerno, Italy
    • ,
  • on behalf of The Italian Group for Antiemetic Research in Radiotherapy – IGARR

Received 30 January 2009 ,Revised 2 November 2009 ,Accepted 10 November 2009.

References 

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  2. Feyer PC, Stewart AL, Titlbach OJ. Aetiology and prevention of emesis induced by radiotherapy. Support Care Cancer. 1998;6:253–260
  3. Goldsmith B. Antiemetic patterns of care for radiotherapy-induced nausea and vomiting (Abstr.). Proc Am Soc Clin Oncol (ASCO). 2003;22:740
  4. Maranzano E, Feyer CP, Molassiotis A, et al. Evidence-based recommendations for the use of antiemetics in radiotherapy. Radiother Oncol. 2005;76:227–233
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  9. Spitzer TR, Bryson JC, Cirenza E, et al. Randomized double-blind, placebo-controlled evaluation of oral ondansetron in the prevention of nausea and vomiting associated with fractionated total-body irradiation. J Clin Oncol. 1995;12:2432–2438
  10. Bey P, Wilkinson PM, Resbeut M, et al. A double-blind, placebo-controlled trial of i.v. dolasetron mesilate in the prevention of radiotherapy-induced nausea and vomiting in cancer patients. Support Care Cancer. 1996;4:278–283
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  12. Prentice HG, Cunningham S, Gandhi L, et al. Granisetron in the prevention of irradiation-induced emesis. Bone Marrow Transplant. 1995;15:445–448
  13. Ungerleider JT, Andrysiak TA, Fairbanks LA, et al. Tetrahydrocannabinol vs prochlorperazine. The effects of two antiemetics on patients undergoing radiotherapy. Radiology. 1984;150:598–599
  14. The Italian Group for Antiemetic Research in Radiotherapy: radiation-induced emesis: a prospective observational multicenter Italian trial. Int J Radiat Oncol Biol Phys. 1999;44:619–625
  15. The Antiemetic Subcommittee of the Multinational Association of Supportive Care in Cancer (MASCC): prevention of chemotherapy- and radiotherapy-induced emesis: results of the 2004 Perugia International Antiemetic Consensus Conference. Ann Oncol. 2006;17:20–28
  16. Feyer CP, Maranzano E, Molassiotis A, et al. Radiotherapy-induced nausea and vomiting (RINV): antiemetic guidelines. Support Care Cancer. 2005;13:122–128
  17. Horiot JC. Prophylaxis versus treatment: is there a better way to manage radiotherapy-induced nausea and vomiting?. Int J Radiat Oncol Biol Phys. 2004;60:1018–1025
  18. Tramer MR, Reynolds DJ, Stoner NS, et al. Efficacy of 5-HT3 receptor antagonists in radiotherapy-induced nausea and vomiting: a quantitative systematic review. Eur J Cancer. 1998;34:1836–1844
  19. Maranzano E. Radiation-induced emesis: a problem with many open questions. Tumori. 2001;87:213–218
  20. Maranzano E. Prophylaxis of radiation-induced emesis. In:  Donnerer J editors. Antiemetic therapy. Basel: Karger; 2003;p. 179–191
  21. Maranzano E, Bellavita R, De Angelis V, et al. Double-blind randomized clinical trial comparing prophylaxis vs. rescue treatment in patients undergoing fractionated upper abdomen radiotherapy (Abstr.). Radiother Oncol. 2004;73:S388
  22. Enblom A, Axelsson BB, Steineck G, Hammar M, Börjeson S. One third of patients with radiotherapy-induced nausea consider their antiemetic treatment insufficient. Support Care Cancer. 2009;17:23–32
  23. Scarantino CW, Ornitz RD, Hoffman LG, et al. Radiation-induced emesis: effects of ondansetron. Semin Oncol. 1992;6:38–43

PII: S0167-8140(09)00613-6

doi: 10.1016/j.radonc.2009.11.001

Radiotherapy & Oncology
Volume 94, Issue 1 , Pages 36-41 , January 2010

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