Low rate of thoracic toxicity in palliative paraspinal single-fraction stereotactic body radiation therapy
Received 9 June 2009; received in revised form 29 September 2009; accepted 11 October 2009. published online 18 November 2009.
Abstract
Background
There has been an increase in the utilization of single-fraction stereotactic body radiation therapy (SBRT) to treat thoracic structures, but there have been few reports describing toxicity outcomes with this treatment.
Methods
We evaluated 119 sites (114 patients) with no prior history of thoracic radiation were treated from 10/1/2003 to 10/27/2008 with single-fraction SBRT to thoracic structures. The median dose to the gross tumor volume was 2400cGy (range 1800–2400cGy), as was the median dose to the planning target volume (range 1600–2400cGy). A detailed review of thoracic toxicities was performed to include pneumonitis or Grade 2 or higher esophageal and bronchial toxicity. In addition, we retrospectively contoured the esophagus and bronchus of 48 patients treated in 2004–2005, prior to the establishment of dose constraints to determine the range of doses that these structures received.
Results
Of the contoured patients, the median dose to the hottest 1cc (D1cc) of the esophagus was 1250cGy (range 158–2572cGy). The median bronchial D1cc was 1101cGy (range 260–2211cGy). At a median follow-up of 11.6months, there were seven Grade 2 or higher esophageal toxicities, including one Grade 3 and one Grade 4 toxicities. There were two bronchial toxicities, one Grade 2 and one Grade 3. There were no cases of pneumonitis.
Conclusions
High-dose single-fraction SBRT is well tolerated to the thoracic region, with most patients tolerating high doses to central structures without significant toxicity.
Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
Corresponding author. Address: Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, United States.
ABSTRACT