Radiotherapy & Oncology
Volume 94, Issue 1 , Pages 30-35 , January 2010

HPV-associated p16-expression and response to hypoxic modification of radiotherapy in head and neck cancer

  • Pernille Lassen

      Affiliations

    • Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    • Corresponding Author InformationCorresponding author. Address: Department of Experimental Clinical Oncology, Aarhus University Hospital, Noerrebrogade 44, DK-8000 Aarhus C, Denmark.
    • ,
  • Jesper Grau Eriksen

      Affiliations

    • Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    • ,
  • Stephen Hamilton-Dutoit

      Affiliations

    • Institute of Pathology, Aarhus University Hospital, Denmark
    • ,
  • Trine Tramm

      Affiliations

    • Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    • Institute of Pathology, Aarhus University Hospital, Denmark
    • ,
  • Jan Alsner

      Affiliations

    • Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    • ,
  • Jens Overgaard

      Affiliations

    • Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    • ,
  • On behalf of the Danish Head and Neck Cancer Group (DAHANCA)

Received 27 July 2009 ,Revised 13 October 2009 ,Accepted 14 October 2009.

References 

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  2. D’Souza G, Kreimer AR, Viscidi R, et al. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med. 2007;356:1944–1956
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  8. Smeets SJ, Hesselink AT, Speel EJ, et al. A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen. Int J Cancer. 2007;121:2465–2472
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  16. Overgaard J, Hansen HS, Overgaard M, et al. A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85. Radiother Oncol. 1998;46:135–146
  17. Overgaard J, Eriksen JG, Nordsmark M, Alsner J, Horsman MR. Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomised double-blind placebo-controlled trial. Lancet Oncol. 2005;6:757–764
  18. Eriksen JG, Overgaard J. Lack of prognostic and predictive value of CA IX in radiotherapy of squamous cell carcinoma of the head and neck with known modifiable hypoxia: an evaluation of the DAHANCA 5 study. Radiother Oncol. 2007;83:383–388
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PII: S0167-8140(09)00588-X

doi: 10.1016/j.radonc.2009.10.008

Radiotherapy & Oncology
Volume 94, Issue 1 , Pages 30-35 , January 2010

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