Radiotherapy & Oncology
Volume 94, Issue 1 , Pages 60-66 , January 2010

A treatment planning study comparing helical tomotherapy with intensity-modulated radiotherapy for the treatment of anal cancer

  • Kurian Jones Joseph

      Affiliations

    • Division of Radiation Oncology
    • Corresponding Author InformationCorresponding author. Address: Department of Radiation Oncology, Cross Cancer Institute, 11560 University Avenue, Edmonton, AB, Canada TG6 1Z2.
    • ,
  • Alasdair Syme

      Affiliations

    • Division of Medical Physics, Department of Oncology, University of Alberta, Edmonton, Canada
    • ,
  • Cormac Small

      Affiliations

    • Division of Radiation Oncology
    • ,
  • Heather Warkentin

      Affiliations

    • Division of Medical Physics, Department of Oncology, University of Alberta, Edmonton, Canada
    • ,
  • Harvey Quon

      Affiliations

    • Division of Radiation Oncology
    • ,
  • Sunita Ghosh

      Affiliations

    • Division of Experimental Oncology and
    • ,
  • Colin Field

      Affiliations

    • Division of Medical Physics, Department of Oncology, University of Alberta, Edmonton, Canada
    • ,
  • Nadeem Pervez

      Affiliations

    • Division of Radiation Oncology
    • ,
  • Keith Tankel

      Affiliations

    • Division of Radiation Oncology
    • ,
  • Samir Patel

      Affiliations

    • Division of Radiation Oncology
    • ,
  • Nawaid Usmani

      Affiliations

    • Division of Radiation Oncology
    • ,
  • Diane Severin

      Affiliations

    • Division of Radiation Oncology
    • ,
  • Tirath Nijjar

      Affiliations

    • Division of Radiation Oncology
    • ,
  • Gino Fallone

      Affiliations

    • Division of Medical Physics, Department of Oncology, University of Alberta, Edmonton, Canada
    • ,
  • John Pedersen

      Affiliations

    • Division of Radiation Oncology

Received 26 November 2008 ,Revised 28 September 2009 ,Accepted 3 October 2009.

References 

  1. UKCCCR Anal Cancer Trial Working Party, UK Co-ordinating Committee on Cancer Research: epidermoid anal cancer . Results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin. Lancet. 1996;348:1049–1054
  2. Bartelink H, Roelofsen F, Eschwege F, et al. Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups. J Clin Oncol. 1997;15:2040–2049
  3. Flam M, John M, Pajak TF, et al. Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study. J Clin Oncol. 1996;14:2527–2539
  4. Milano MT, Jani AB, Farrey KJ, et al. Intensity-modulated radiation therapy (IMRT) in the treatment of anal cancer: toxicity and clinical outcome. Int J Radiat Oncol Biol Phys. 2005;63:354–361
  5. Saarilahti K, Arponen P, Vaalavirta P, et al. The effect of intensity-modulated radiotherapy and high dose rate brachytherapy on acute and late radiotherapy-related adverse events following chemoradiotherapy of anal cancer. Radiother Oncol. 2008;87:383–390
  6. Vuong T, Devic S, Belliveau P, et al. Contribution of conformal therapy in the treatment of anal canal carcinoma with combined chemotherapy and radiotherapy: results of a phase II study. Int J Radiat Oncol Biol Phys. 2003;56:823–831
  7. Cummings BJ, Keane TJ, O’Sullivan B, et al. Epidermoid anal cancer: treatment by radiation alone or by radiation and 5-fluorouracil with and without mitomycin C. Int J Radiat Oncol Biol Phys. 1991;21:1115–1125
  8. Ajani JA, Winter KA, Gunderson LL, et al. Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial. JAMA. 2008;299:1914–1921
  9. Salama JK, Mell LK, Schomas DA, et al. Concurrent chemotherapy and intensity-modulated radiation therapy for anal canal cancer patients: a multicenter experience. J Clin Oncol. 2007;25:4581–4586
  10. Sheng K, Molloy JA, Larner JM, et al. A dosimetric comparison of non-coplanar IMRT versus helical tomotherapy for nasal cavity and paranasal sinus cancer. Radiother Oncol. 2007;82:174–178
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  16. Kissick MW, Fenwick J, James JA, et al. The helical tomotherapy thread effect. Med Phys. 2005;32:1414–1423
  17. Nutting CM, Bedford JL, Cosgrove VP, et al. A comparison of conformal and intensity-modulated techniques for oesophageal radiotherapy. Radiother Oncol. 2001;61:157–163
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  19. Iori M, Cattaneo GM, Cagni E, et al. Dose–volume and biological-model based comparison between helical tomotherapy and (inverse-planned) IMAT for prostate tumours. Radiother Oncol. 2008;88:34–45
  20. Bauman G, Rodrigues G, Yartsev S, et al. A prospective evaluation of helical tomotherapy. Int J Radiat Oncol Biol Phys. 2007;68:632–641
  21. Mell LK, Schomas DA, Salama JK, et al. Association between bone marrow dosimetric parameters and acute hematologic toxicity in anal cancer patients treated with concurrent chemotherapy and intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys. 2008;70:1431–1437
  22. Nuyttens JJ, Robertson JM, Yan D, et al. The variability of the clinical target volume for rectal cancer due to internal organ motion during adjuvant treatment. Int J Radiat Oncol Biol Phys. 2002;53:497–503
  23. Nuyttens JJ, Robertson JM, Yan D, et al. The influence of small bowel motion on both a conventional three-field and intensity modulated radiation therapy (IMRT) for rectal cancer. Cancer Radiother. 2004;8:297–304

☆ Presented in part at the annual meeting of the Canadian Association of Radiation Oncology on October 9–13, 2007, Toronto, Ontario, Canada.

PII: S0167-8140(09)00569-6

doi: 10.1016/j.radonc.2009.10.003

Radiotherapy & Oncology
Volume 94, Issue 1 , Pages 60-66 , January 2010

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