Mechanism of lapatinib-mediated radiosensitization of breast cancer cells is primarily by inhibition of the Raf>MEK>ERK mitogen-activated protein kinase cascade and radiosensitization of lapatinib-resistant cells restored by direct inhibition of MEK

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Volume 93, Issue 3 , Pages 639-644, December 2009

Maria J. Sambade
- Department of Radiation Oncology and
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC, USA
J. Terese Camp
- Department of Radiation Oncology and
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC, USA
Randall J. Kimple
- Department of Radiation Oncology and
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC, USA
Carolyn I. Sartor
- Department of Radiation Oncology and
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC, USA
Janiel M. Shields
- Department of Radiation Oncology and
- Department of Dermatology, University of North Carolina at Chapel Hill, NC, USA
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC, USA
- Corresponding author. Address: Department of Radiation Oncology, University of North Carolina, School of Medicine, LCCC Rm 12-048, CB 7295, Chapel Hill, NC 27599, USA.