Radiotherapy & Oncology
Volume 93, Issue 3 , Pages 419-423 , December 2009

4D-CT-based target volume definition in stereotactic radiotherapy of lung tumours: Comparison with a conventional technique using individual margins

  • Holger Hof

      Affiliations

    • University of Heidelberg, Department of Radiation Oncology, Heidelberg, Germany
    • Corresponding Author InformationCorresponding author. Address: Universitaetsklinikum Heidelberg, Abt. Radioonkologie und Strahlentherapie, INF 400, D-69120 Heidelberg, Germany.
    • ,
  • Bernhard Rhein

      Affiliations

    • German Cancer Research Center (DKFZ), Department of Medical Physics, Heidelberg, Germany
    • ,
  • Peter Haering

      Affiliations

    • German Cancer Research Center (DKFZ), Department of Medical Physics, Heidelberg, Germany
    • ,
  • Annette Kopp-Schneider

      Affiliations

    • German Cancer Research Center (DKFZ), Division of Biostatistics, Heidelberg, Germany
    • ,
  • Jürgen Debus

      Affiliations

    • University of Heidelberg, Department of Radiation Oncology, Heidelberg, Germany
    • ,
  • Klaus Herfarth

      Affiliations

    • University of Heidelberg, Department of Radiation Oncology, Heidelberg, Germany

Received 27 March 2009 ,Revised 24 August 2009 ,Accepted 25 August 2009.

References 

  1. Guckenberger M, Krieger T, Richter A, et al. Potential of image-guidance, gating and real-time tracking to improve accuracy in pulmonary stereotactic body radiotherapy. Radiother Oncol. 2009;91:288–295
  2. Seppenwoolde Y, Shirato H, Kitamura K, et al. Precise and real-time measurement of 3D tumor motion in lung due to breathing and heartbeat, measured during radiotherapy. Int J Radiat Oncol Biol Phys. 2002;53:822–834
  3. Burnett SSC, Sixel KE, Cheung PCF, Hoisak JDP. A study of tumor motion management in the conformal radiotherapy of lung cancer. Radiother Oncol. 2008;86:77–85
  4. Sixel KE, Ruschin M, Tirona R, Cheung PCF. Digital fluoroscopy to quantify lung tumor motion: potential for patient-specific planning target volumes. Int J Radiat Oncol Biol Phys. 2003;57:717–723
  5. Hof H, Herfarth KK, Münter M, et al. The use of the multislice CT for the determination of respiratory lung tumor movement in stereotactic single-dose irradiation. Strahlenther Onkol. 2003;179:542–547
  6. Rietzel E, Pan T, Chen GTY. Four-dimensional computed tomography: image formation and clinical protocol. Med Phys. 2005;32:874–889
  7. Stevens CW, Munden RF, Forster KM, et al. Respiratory-driven lung tumor motion is independent of tumor size, tumor location, and pulmonary function. Int J Radiat Oncol Biol Phys. 2001;51:62–68
  8. Keall PJ, Starkschall G, Shukla H, et al. Acquiring 4D thoracic CT scans using a multislice helical method. Phys Med Biol. 2004;49:2053–2067
  9. Vedam SS, Keall PJ, Kini VR, et al. Acquiring a four-dimensional computed tomography dataset using an external respiratory signal. Phys Med Biol. 2003;48:45–62
  10. Wang L, Hayes S, Paskalev K, et al. Dosimetric comparison of stereotactic body radiotherapy using 4D CT and multiphase CT images for treatment planning of lung cancer: evaluation of the impact on daily dose coverage. Radiother Oncol. 2009;91:314–324
  11. Rietzel E, Liu AK, Doppke KP, et al. Design of 4D treatment planning target volumes. Int J Radiat Oncol Biol Phys. 2006;66:287–295
  12. Wu J, Li H, Shekhar R, Suntharalingam M, D’Souza W. An evaluation of planning techniques for stereotactic body radiation therapy in lung tumors. Radiother Oncol. 2008;87:35–43
  13. Hof H, Hoess A, Oetzel D, Debus J, Herfarth K. Stereotactic single-dose radiotherapy of lung metastases. Strahlenther Onkol. 2007;183:673–678
  14. Hof H, Muenter M, Oetzel D, et al. Stereotactic single-dose radiotherapy (radiosurgery) of early stage nonsmall-cell lung cancer (NSCLC). Cancer. 2007;110:148–155
  15. Dinkel J, Welzel T, Bolte H, et al. Four-dimensional multislice helical CT of the lung: qualitative comparison of retrospectively gated and static images in an ex-vivo system. Radiother Oncol. 2007;85:215–222
  16. Underberg RWM, Lagerwaard FJ, Slotman BJ, Cuijpers JP, Senan S. Benefit of respiration-gated stereotactic radiotherapy for stage I lung cancer: an analysis of 4DCT datasets. Int J Radiat Oncol Biol Phys. 2005;62:554–560
  17. Rietzel E, Chen GTY, Choi NC, Willet CG. Four-dimensional image-based treatment planning: target volume segmentation and dose calculation in the presence of respiratory motion. Int J Radiat Oncol Biol Phys. 2005;61:1535–1550
  18. Balter JM, Ten Haken RK, Lawrence TS, Lam KL, Robertson JM. Uncertainties in CT-based radiation therapy treatment planning associated with patient breathing. Int J Radiat Oncol Biol Phys. 1996;36:167–174
  19. Underberg RWM, Lagerwaard FJ, Cuijpers JP, et al. Four-dimensional CT scans for treatment planning in stereotactic radiotherapy for stage I lung cancer. Int J Radiat Oncol Biol Phys. 2004;60:1283–1290
  20. Jin J, Ajlouni M, Chen Q, et al. Quantification of incidental dose to potential clinical target volume (CTV) under different stereotactic body radiation therapy (SBRT) techniques for non-small cell lung cancer – tumor motion and using internal target volume (ITV) could improve dose distribution in CTV. Radiother Oncol. 2007;85:267–276
  21. Bradley JD, Nofal AN, El Naqa IM, et al. Comparison of helical, maximum intensity projection (MIP), and averaged intensity (AI) 4D CT imaging for stereotactic body radiation therapy (SBRT) planning in lung cancer. Radiother Oncol. 2006;81:264–268
  22. Ehler ED, Tomé WA. Lung 4D-IMRT treatment planning: an evaluation of three methods applied to four-dimensional data sets. Radiother Oncol. 2008;88:319–325
  23. Xi M, Liu M, Deng X, et al. Defining internal target volume (ITV) for hepatocellular carcinoma using four-dimensional CT. Radiother Oncol. 2007;84:272–278
  24. Gagné IM, Robinson DM. The impact of tumor motion upon CT image integrity and target delineation. Med Phys. 2004;31:3378–3392
  25. Nakamura M, Narita Y, Matsuo Y, et al. Geometrical differences in target volumes between slow CT and 4D CT imaging in stereotactic body radiotherapy for lung tumors in the upper and middle lobe. Med Phys. 2008;35:4142–4148
  26. Seki S, Kunieda E, Takeda A, et al. Differences in the definition of internal target volumes using slow CT alone or in combination with thin-slice CT under breath-holding conditions during the planning of stereotactic radiotherapy for lung cancer. Radiother Oncol. 2007;85:443–449
  27. Hara R, Itami J, Kondo T, et al. Clinical outcomes of single-fraction stereotactic radiation therapy of lung tumors. Cancer. 2006;106:1347–1352
  28. Timmerman R, McGarry R, Yiannoutsos C, et al. Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer. J Clin Oncol. 2006;24:4833–4839
  29. Seppenwoolde Y, Lebesque JV, de Jaeger K, et al. Comparing different NTCP models that predict the incidence of radiation pneumonitis. Normal tissue complication probability. Int J Radiat Oncol Biol Phys. 2003;55:724–735

PII: S0167-8140(09)00492-7

doi: 10.1016/j.radonc.2009.08.040

Radiotherapy & Oncology
Volume 93, Issue 3 , Pages 419-423 , December 2009

Article Tools

* Image Usage & Resolution