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Radiotherapy & Oncology
Volume 92, Issue 3
, Pages 371-378
, September 2009
3D cell cultures of human head and neck squamous cell carcinoma cells are radiosensitized by the focal adhesion kinase inhibitor TAE226
References
- . Exploring the role of cancer stem cells in radioresistance. Nat Rev Cancer. 2008;8:545–554
- . Cancer stem cells: redefining the paradigm of cancer treatment strategies. Mol Interv. 2006;6:140–148
- . Tumour stem cells and drug resistance. Nat Rev Cancer. 2005;5:275–284
- . Targeting molecular determinants of tumor chemo-radioresistance. Semin Oncol. 2005;32:S78–S81
- EGFR-targeted anti-cancer drugs in radiotherapy: preclinical evaluation of mechanisms. Radiother Oncol. 2007;83:238–248
- . Cell adhesion-mediated radioresistance (CAM-RR) extracellular matrix-dependent improvement of cell survival in human tumor and normal cells in vitro. Strahlenther Onkol. 2003;179:337–344
- . Signalling via integrins: implications for cell survival and anticancer strategies. Biochim Biophys Acta. 2007;1775:163–180
- . A review of the role of insulin-like growth factor 2 in malignancy and its potential as a modifier of radiation sensitivity. Clin Oncol [R Coll Radiol]. 2008;20:345–352
- . Antiproliferative effects of EGFR tyrosine kinase inhibition and radiation-induced genotoxic injury are attenuated by adhesion to fibronectin. Radiother Oncol. 2006;80:178–184
- . Pharmacological inhibition of EGFR tyrosine kinase affects ILK-mediated cellular radiosensitization in vitro. Int J Radiat Biol. 2007;83:793–802
- . Focal adhesion kinase: targeting adhesion signaling pathways for therapeutic intervention. Clin Cancer Res. 2008;14:627–632
- . Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics. Exp Cell Res. 2000;261:25–36
- Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin Cancer Res. 2000;6:2417–2423
- . Adhesion systems in normal breast and in invasive breast carcinoma. Am J Pathol. 1995;146:706–716
- . Overexpression of focal adhesion kinase (p125FAK) in human colorectal carcinoma liver metastases: independence from c-src or c-yes activation. Ann Surg Oncol. 1997;4:264–268
- Prognostic significance of expression of nm23–H1 and focal adhesion kinase in non-small cell lung cancer. Oncol Rep. 2007;18:81–85
- . Focal adhesion kinase expression in oral cancers. Head Neck. 1998;20:634–639
- Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res. 1995;55:2752–2755
- Inhibition of focal adhesion kinase as a potential therapeutic strategy for imatinib-resistant gastrointestinal stromal tumor. Mol Cancer Ther. 2009;8:127–134
- Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion. Am J Pathol. 2004;165:1087–1095
- . Ionizing radiation modules of the expression and tyrosine phosphorylation of the focal adhesion-associated proteins focal adhesion kinase (FAK) and its substrates p130cas and paxillin in A549 human lung carcinoma cells in vitro. Int J Radiat Biol. 2003;79:721–731
- Human pancreatic tumor cells are sensitized to ionizing radiation by knockdown of caveolin-1. Oncogene. 2007;26:6851–6862
- . Antiapoptotic action of focal adhesion kinase (FAK) against ionizing radiation. Antioxid Redox Signal. 2002;4:491–499
- . The role of focal-adhesion kinase in cancer – a new therapeutic opportunity. Nat Rev Cancer. 2005;5:505–515
- . Anti-apoptotic role of focal adhesion kinase (FAK). Induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60. J Biol Chem. 2000;275:16309–16315
- . Integrin-mediated signalling through the MAP-kinase pathway. IET Syst Biol. 2008;2:8–15
- . FERM control of FAK function: implications for cancer therapy. Cell Cycle. 2008;7:2306–2314
- . Signal transduction by focal adhesion kinase in cancer. Cancer Metastasis Rev. 2009;
- N-MYC regulates focal adhesion kinase expression in human neuroblastoma. J Biol Chem. 2007;282:12503–12516
- . Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells. J Biol Chem. 2002;277:38978–38987
- Focal adhesion kinase silencing augments docetaxel-mediated apoptosis in ovarian cancer cells. Clin Cancer Res. 2005;11:8829–8836
- The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways. J Biol Chem. 2000;275:30597–30604
- Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562, 271. Cancer Res. 2008;68:1935–1944
- Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem. 2007;282:14845–14852
- . TAE226 inhibits human neuroblastoma cell survival. Cancer Invest. 2008;26:145–151
- . TAE226-induced apoptosis in breast cancer cells with overexpressed Src or EGFR. Mol Carcinog. 2008;47:222–234
- A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth. Mol Carcinog. 2007;46:488–496
- TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells. Oncol Rep. 2008;20:1473–1477
- Dual tyrosine kinase inhibitor for focal adhesion kinase and insulin-like growth factor-I receptor exhibits anticancer effect in esophageal adenocarcinoma in vitro and in vivo. Clin Cancer Res. 2008;14:4631–4639
- . Integrin-linked kinase: dispensable for radiation survival of three-dimensionally cultured fibroblasts. Radiother Oncol. 2008;86:329–335
- Pre-treatment number of clonogenic cells and their radiosensitivity are major determinants of local tumour control after fractionated irradiation. Radiother Oncol. 2007;83:304–310
- . The effect of dimethyl sulfoxide on the neuronal excitability and cholinergic transmission in aplysia ganglion cells. Ann NY Acad Sci. 1975;243:337–357
- . Mechanism of erythropoietin action on the erythroid progenitor cells induced from murine erythroleukemia cells (TSA8). Development. 1989;105:109–114
- . Thermodynamic studies of cellular adhesion. Trans Am Soc Artif Intern Organs. 1979;25:152–158
- . Effects of sodium butyrate and dimethylsulfoxide on human pancreatic tumor cell lines. Eur J Cancer Clin Oncol. 1984;20:265–271
- . New roles for integrins in squamous-cell carcinoma. Nat Rev Cancer. 2006;6:175–183
- . Protein tyrosine kinases: structure, substrate specificity, and drug discovery. Biopolymers. 1998;47:197–223
- . Induction of cell death by radiotherapy. Endocr Relat Cancer. 1999;6:41–44
PII: S0167-8140(09)00434-4
doi: 10.1016/j.radonc.2009.08.001
© 2009 Elsevier Ireland Ltd. All rights reserved.
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Radiotherapy & Oncology
Volume 92, Issue 3
, Pages 371-378
, September 2009
