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Radiotherapy & Oncology
Volume 92, Issue 3
, Pages 329-333
, September 2009
Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells
References
- . On respiratory impairment in cancer cells. Science. 1956;124:269–270
- . On the origin of cancer cells. Science. 1956;123:309–314
- The bioenergetic signature of cancer: a marker of tumor progression. Cancer Res. 2002;62:6674–6681
- Loss of the mitochondrial bioenergetic capacity underlies the glucose avidity of carcinomas. Cancer Res. 2007;67:9013–9017
- . Mitochondrial mutations in cancer. Oncogene. 2006;25:4647–4662
- Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. Science. 2000;287:848–851
- Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat Genet. 2002;30:406–410
- . Energy metabolism in tumor cells. FEBS J. 2007;274:1393–1418
- . The role of the Crabtree effect and an endogenous fuel in the energy metabolism of resting and proliferating thymocytes. Eur J Biochem. 1993;212:95–99
- . Cooperation and competition in the evolution of ATP-producing pathways. Science. 2001;292:504–507
- . Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin Cancer Biol. 2005;15:300–308
- The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature. 2008;452:230–233
- . HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 2006;3:177–185
- . HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab. 2006;3:187–197
- c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc Natl Acad Sci USA. 1997;94:6658–6663
- . Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell. 2006;9:425–434
- . Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature. 2008;452:181–186
- . Mitochondrial metabolism of glutamine and glutamate and its physiological significance. Physiol Rev. 1983;63:547–605
- Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci USA. 2007;104:19345–19350
- . Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature. 2006;441:424–430
- . The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol. 2004;22:2954–2963
- . Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene. 2004;23:3151–3171
- Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ. 2001;12:363–369
- Impact of cyclic hypoxia on HIF-1alpha regulation in endothelial cells – new insights for anti-tumor treatments. FEBS J. 2009;276:509–518
- . Causes and consequences of increased glucose metabolism of cancers. J Nucl Med. 2008;49:24S–42S
- . Why do cancers have high aerobic glycolysis?. Nat Rev Cancer. 2004;4:891–899
- . The carbohydrate metabolism of certain pathological overgrowths. Biochem J. 1928;22:1289–1298
- . Targeting HIF-1 for cancer therapy. Nat Rev Cancer. 2003;3:721–732
- HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell. 2007;129:111–122
- Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis. Mol Cell Biol. 2005;25:6225–6234
- A large scale genetic analysis of c-Myc-regulated gene expression patterns. J Biol Chem. 2003;278:12563–12573
- . Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. J Cell Biol. 2007;178:93–105
- Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci USA. 2008;105:18782–18787
- c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature. 2009;458:762–765
- . Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells. Biochem J. 2002;364:309–315
- Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest. 2008;118:3930–3942
- . The expression of lactate transporters (MCT1 and MCT4) in heart and muscle. Eur J Appl Physiol. 2001;86:6–11
PII: S0167-8140(09)00336-3
doi: 10.1016/j.radonc.2009.06.025
© 2009 Elsevier Ireland Ltd. All rights reserved.
« Previous
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Radiotherapy & Oncology
Volume 92, Issue 3
, Pages 329-333
, September 2009
