Radiotherapy & Oncology
Volume 92, Issue 3 , Pages 379-382 , September 2009

Radiation-induced lipid peroxidation activates src kinase and triggers nuclear EGFR transport

  • Klaus Dittmann

      Affiliations

    • Department of Radiation Oncology, Eberhard-Karls-University, Röntgenweg, Germany
    • Corresponding Author InformationCorresponding author. Address: Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard-Karls-University, Roentgenweg 11, 72076 Tuebingen, Germany.
  • ,
  • Claus Mayer

      Affiliations

    • Department of Radiation Oncology, Eberhard-Karls-University, Röntgenweg, Germany
  • ,
  • Rainer Kehlbach

      Affiliations

    • Department of Radiology, University of Tuebingen, Germany
  • ,
  • Marie-Christine Rothmund

      Affiliations

    • Department of Radiation Oncology, Eberhard-Karls-University, Röntgenweg, Germany
  • ,
  • H. Peter Rodemann

      Affiliations

    • Department of Radiation Oncology, Eberhard-Karls-University, Röntgenweg, Germany

Received 24 April 2009 ,Accepted 3 June 2009.

References 

  1. Bussink J, Kaanders JH, van der Kogel AJ. Microenvironmental transformations by VEGF- and EGF-receptor inhibition and potential implications for responsiveness to radiotherapy. Radiother Oncol. 2007;82:10–17
  2. Bussink J, van der Kogel AJ, Kaanders JH. Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer. Lancet Oncol. 2008;9:288–296
  3. Demozay D, Mas JC, Rocchi S, et al. FALDH reverses the deleterious action of oxidative stress induced by lipid peroxidation product 4-hydroxynonenal on insulin signaling in 3T3-L1 adipocytes. Diabetes. 2008;57:1216–1226
  4. Dittmann K, Mayer C, Fehrenbacher B, et al. Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase. J Biol Chem. 2005;280:31182–31189
  5. Dittmann K, Mayer C, Kehlbach R, et al. The radioprotector Bowman–Birk proteinase inhibitor stimulates DNA repair via epidermal growth factor receptor phosphorylation and nuclear transport. Radiother Oncol. 2008;86:375–382
  6. Dittmann K, Mayer C, Kehlbach R, et al. Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport, activation of DNA-PK. Mol Cancer. 2008;7:69
  7. Dittmann K, Mayer C, Rodemann HP. Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity. Radiother Oncol. 2005;76:157–161
  8. Dittmann K, Mayer C, Wanner G, et al. The radioprotector O-phospho-tyrosine stimulates DNA-repair via epidermal growth factor receptor- and DNA-dependent kinase phosphorylation. Radiother Oncol. 2007;84:328–334
  9. Dwivedi S, Sharma A, Patrick B, et al. Role of 4-hydroxynonenal and its metabolites in signaling. Redox Rep. 2007;12:4–10
  10. Giannoni E, Buricchi F, Raugei G, et al. Intracellular reactive oxygen species activate src tyrosine kinase during cell adhesion and anchorage-dependent cell growth. Mol Cell Biol. 2005;25:6391–6403
  11. Khan EM, Heidinger JM, Levy M, et al. Epidermal growth factor receptor exposed to oxidative stress undergoes Src- and caveolin-1-dependent perinuclear trafficking. J Biol Chem. 2006;281:14486–14493
  12. Knebel A, Rahmsdorf HJ, Ullrich A, et al. Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents. EMBO J. 1996;15:5314–5325
  13. Liu W, Akhand AA, Kato M, et al. 4-Hydroxynonenal triggers an epidermal growth factor receptor-linked signal pathway for growth inhibition. J Cell Sci. 1999;112:2409–2417
  14. Nakashima I, Kato M, Akhand AA, et al. Redox-linked signal transduction pathways for protein tyrosine kinase activation. Antioxid Redox Signal. 2002;4:517–531
  15. Peng XH, Karna P, Cao Z, et al. Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression. J Biol Chem. 2006;281:25903–25914
  16. Rodemann HP, Dittmann K, Toulany M. Radiation-induced EGFR-signaling and control of DNA-damage repair. Int J Radiat Biol. 2007;83:781–791
  17. Schmidt-Ullrich RK, Mikkelsen RB, Dent P, et al. Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation. Oncogene. 1997;15:1191–1197
  18. Tanito M, Haniu H, Elliott MH, et al. Identification of 4-hydroxynonenal-modified retinal proteins induced by photooxidative stress prior to retinal degeneration. Free Radic Biol Med. 2006;41:1847–1859
  19. Tanos B, Pendergast AM. Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor. J Biol Chem. 2006;281:32714–32723
  20. Wang Q, Zhu F, Wang Z. Identification of EGF receptor C-terminal sequences 1005–1017 and di-leucine motif 1010LL1011 as essential in EGF receptor endocytosis. Exp Cell Res. 2007;313:3349–3363
  21. Wanner G, Mayer C, Kehlbach R, et al. Activation of protein kinase Cepsilon stimulates DNA-repair via epidermal growth factor receptor nuclear accumulation. Radiother Oncol. 2008;86:383–390
  22. Yotsumoto F, Yagi H, Suzuki SO, et al. Validation of HB-EGF and amphiregulin as targets for human cancer therapy. Biochem Biophys Res Commun. 2008;365:555–561
  23. Zarkovic N. 4-Hydroxynonenal as a bioactive marker of pathophysiological processes. Mol Aspects Med. 2003;24:281–291

PII: S0167-8140(09)00300-4

doi: 10.1016/j.radonc.2009.06.003

Radiotherapy & Oncology
Volume 92, Issue 3 , Pages 379-382 , September 2009