Radiotherapy & Oncology
Volume 92, Issue 1 , Pages 4-14 , July 2009

Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 93 randomised trials and 17,346 patients

  • Jean-Pierre Pignon

      Affiliations

    • Department of Biostatistics and Epidemiology, Institut Gustave-Roussy, Villejuif, France
    • Corresponding Author InformationCorresponding author. Address: Department of Biostatistics and Epidemiology, Institut Gustave-Roussy, 39 rue Camille Desmoulins, 94 805 VILLEJUIF cedex, France.
    • ,
  • Aurélie le Maître

      Affiliations

    • Department of Biostatistics and Epidemiology, Institut Gustave-Roussy, Villejuif, France
    • ,
  • Emilie Maillard

      Affiliations

    • Department of Biostatistics and Epidemiology, Institut Gustave-Roussy, Villejuif, France
    • ,
  • Jean Bourhis

      Affiliations

    • Department of Radiotherapy, Institut Gustave-Roussy, Villejuif, France
    • ,
  • on behalf of the MACH-NC Collaborative Group

      Affiliations

    • Collaborators listed at the end of the paper.

Received 6 April 2009 ,Revised 17 April 2009 ,Accepted 19 April 2009.

References 

  1. Ferlay F, Bray F, Pisani P, Parkin DM. GLOBOCAN 2002: cancer incidence, mortality and prevalence worldwide. IARC Cancer Base No. 5. Version 2.0. Lyon: IARC Press; 2004.
  2. Pignon J-P, Bourhis J, Domenge C, Désigné L On behalf of the MACH-NC Collaborative Group. Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. Lancet. 2000;255:949–955
  3. Baujat B, Mahé C, Pignon J-P, Hill C. A graphical method for exploring heterogeneity in meta-analysis: application to a meta-analysis of 65 trials. Stat Med. 2002;21:2641–2652
  4. Pignon J-P, Le Maître A, Bourhis J On behalf of the MACH-NC Collaborative Group. Meta-analyses of chemotherapy in head and neck cancer (MACH-NC): an update. Int J Radiat Oncol Biol Phys. 2007;69:S112–S114
  5. Schemper M, Smith TL. A note on quantifying follow-up in studies of failure time. Control Clin Trials. 1996;17:343–346
  6. Yusuf S, Peto R, Lewis J, Collins R, Sleight T. Beta blockade during and after myocardial infarction: an overview of randomised clinical trials. Prog Cardiovasc Dis. 1985;27:335–371
  7. Early Breast Cancer Trialists’ Collaborative Group. Effects of radiotherapy and surgery in early breast cancer: an overview of randomized trials. N Engl J Med. 1995;333:1444–1455
  8. Non-small Cell Lung Cancer Collaborative Group. Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomized clinical trials. Br Med J. 1995;311:899–909
  9. Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21:1539–1558
  10. Early Breast Cancer Trialists’ Collaborative Group. Systemic treatment of early breast cancer by hormonal, cytotoxic or immune therapy: 133 randomised trials involving 31,000 recurrences and 24,000 death among 75,000 women. Lancet. 1992;339:1–15
  11. Gabriele P, Orecchia R, Ragona R, et al. A cooperative AIRO/Piemonte randomized clinical trial of carboplatin as an adjunct to radiotherapy in head and neck cancer. Radiat Oncol. 1994;32:S93
  12. Bhowmik KT, Safaya A, Sharma R, Suri K, Bhatia JS, Das Nl. Concomitant chemoradiotherapy in advanced head and neck cancers: Safdarjang hospital experience. Radiat Oncol. 2001;58:S16
  13. Haselow RE, Warshaw MG, Oken MM, et al. Radiation alone versus radiation with weekly low dose cisplatinum in unrescetable cancer of the head and neck. In:  Fee WE,  Goepfert H,  Johns ME, et al. editor. Head and neck cancer. vol. II:Philadelphia: BC Decker; 1990;p. 279–281
  14. Bourhis J, Overgaard J, Audry H, et al. Hyperfractionated or accelerated radiotherapy in head and neck cancer: an individual patient data meta-analysis of 15 randomized trials. Lancet. 2006;368:843–854
  15. Available from: http://www.emea.europa.eu/humandocs/PDFs/EPAR/erbitux/Erbitux-H-558-II-05.pdf [last access on November 26, 2008].
  16. Hitt R, Lopez-Pousa A, Martinez-Trufero J, et al. Phase III study comparing cisplatin plus fluorouracil to paclitaxel, cisplatin, and fluorouracil induction chemotherapy followed by chemoradiotherapy in locally advanced head and neck cancer. J Clin Oncol. 2005;23:8636–8645
  17. Posner MR, Hershock DM, Blajman CR, et al. Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer. N Engl J Med. 2007;357:1705–1715
  18. Vermorken JB, Remenar E, van Herpen C, et al. Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer. N Engl J Med. 2007;357:1695–1704
  19. Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006;354:567–578

PII: S0167-8140(09)00188-1

doi: 10.1016/j.radonc.2009.04.014

Radiotherapy & Oncology
Volume 92, Issue 1 , Pages 4-14 , July 2009

Article Tools

* Image Usage & Resolution