Linac-based or robotic image-guided stereotactic radiotherapy for isolated lymph node recurrent prostate cancer

Jereczek-Fossa, Barbara A.; Fariselli, Laura; Beltramo, Giancarlo; Catalano, Gianpiero; Serafini, Flavia; Garibaldi, Cristina; Cambria, Raffaella; Brait, Lorenzo; Possanzini, Marco; Bianchi, Livia C.; Vavassori, Andrea; Zerini, Dario; Orsi, Franco; de Cobelli, Ottavio; Orecchia, Roberto

doi:10.1016/j.radonc.2009.04.001

« Previous Next »Radiotherapy & Oncology
Volume 93, Issue 1 , Pages 14-17, October 2009

Linac-based or robotic image-guided stereotactic radiotherapy for isolated lymph node recurrent prostate cancer

Barbara A. Jereczek-Fossa
- Department of Radiotherapy, European Institute of Oncology, Milan, Italy
- University of Milan, Milan, Italy
- Corresponding author. Address: Department of Radiotherapy, European Institute of Oncology, via Ripamonti 435, Milan 20141, Italy.
Laura Fariselli
- Cyberknife Center CDI, Milan, Italy
- Radiotherapy Unit of the Carlo Besta Neurological Institute Foundation, Milan, Italy
Giancarlo Beltramo
- Cyberknife Center CDI, Milan, Italy
Gianpiero Catalano
- Department of Radiotherapy, European Institute of Oncology, Milan, Italy
Flavia Serafini
- Department of Radiotherapy, European Institute of Oncology, Milan, Italy
Cristina Garibaldi
- Department of Medical Physics, European Institute of Oncology, Milan, Italy
Raffaella Cambria
- Department of Medical Physics, European Institute of Oncology, Milan, Italy
Lorenzo Brait
- Cyberknife Center CDI, Milan, Italy
Marco Possanzini
- Cyberknife Center CDI, Milan, Italy
Livia C. Bianchi
- Cyberknife Center CDI, Milan, Italy
Andrea Vavassori
- Department of Radiotherapy, European Institute of Oncology, Milan, Italy
Dario Zerini
- Department of Radiotherapy, European Institute of Oncology, Milan, Italy
Franco Orsi
- Unit of Interventional Radiology, European Institute of Oncology, Milan, Italy
Ottavio de Cobelli
- Department of Urology, European Institute of Oncology, Milan, Italy
- University of Milan, Milan, Italy
Roberto Orecchia
- Department of Radiotherapy, European Institute of Oncology, Milan, Italy
- University of Milan, Milan, Italy

Received 4 October 2008; received in revised form 26 March 2009; accepted 4 April 2009. published online 01 May 2009.

Abstract

We report on 14 patients treated with linac- or robotic image-guided stereotactic radiotherapy for isolated lymph node recurrence from prostate cancer, up to the mean dose of 30Gy/3 fractions. At the mean follow-up of 18.6months, five patients experienced clinical out-field progression. Toxicity was minimal. Further investigation is warranted in order to identify the patients that benefit most from this treatment modality and to define the optimal association of such local approach with androgen deprivation. Hopefully, effective local therapy might reduce the burden of systemic therapies given to the recurrent/metastatic prostate cancer patients.